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已发表论文
迁移体：疾病诊断与治疗的新角色
Authors Zhang X, Wang S, Jiang Y, Zhu W, Yang Y, Huo L, Zhang Y, Zhou Y, Yang Z, Wang X
Received 17 June 2025
Accepted for publication 23 September 2025
Published 2 October 2025 Volume 2025:19 Pages 561—579
DOI https://doi.org/10.2147/BTT.S547672
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Shein-Chung Chow
Xiaolin Zhang,1 Shang Wang,2 Yuyun Jiang,1 Wei Zhu,1,3 Yanwei Yang,1 Liyue Huo,1 Yubei Zhang,1 Yuepeng Zhou,1 Zhe Yang,1 Xuefeng Wang1,4
1Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China; 2Tzu Chi International College of Traditional Chinese Medicine, Vancouver, BC, Canada; 3Department of Sports Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China; 4Department of Nuclear Medicine, Institute of Digestive Diseases, and Institute of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China
Correspondence: Xuefeng Wang, Email xuefengwang@ujs.edu.cn
Abstract: Migrasomes, vesicle-like organelles observed during cell migration, have emerged as a significant focus in cell biology. These organelles play a pivotal role in intercellular communication, signal transduction, and tissue development through the release of signalling molecules. Evidence indicates that the pathogenesis and progression of various diseases are closely associated with aberrant cell migration, impaired intercellular communication, and disrupted signalling pathways. Notably, migrasomes can facilitate the invasion and metastasis of tumor cells: they carry metastasis-promoting signals and help form an immunosuppressive microenvironment. Additionally, migrasomes mediate viral spread. Migrasomes derived from macrophages can accelerate the progression of cardiovascular and cerebrovascular diseases by promoting neuroinflammation and neuronal damage. Meanwhile, migrasomes derived from podocytes serve as biomarkers for early kidney injury. Thus, elucidating the role of migrasomes in pathological processes and defining their specific functions holds great promise for developing novel therapeutic strategies for diseases. This review synthesizes current advances in migrasome biology, highlighting their potential as diagnostic biomarkers and therapeutic targets for conditions such as cancer, viral infections, and renal disorders.
Keywords: migrasomes, diseases, diagnosis and therapy, cell migration
1Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China; 2Tzu Chi International College of Traditional Chinese Medicine, Vancouver, BC, Canada; 3Department of Sports Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China; 4Department of Nuclear Medicine, Institute of Digestive Diseases, and Institute of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China
Correspondence: Xuefeng Wang, Email xuefengwang@ujs.edu.cn
Abstract: Migrasomes, vesicle-like organelles observed during cell migration, have emerged as a significant focus in cell biology. These organelles play a pivotal role in intercellular communication, signal transduction, and tissue development through the release of signalling molecules. Evidence indicates that the pathogenesis and progression of various diseases are closely associated with aberrant cell migration, impaired intercellular communication, and disrupted signalling pathways. Notably, migrasomes can facilitate the invasion and metastasis of tumor cells: they carry metastasis-promoting signals and help form an immunosuppressive microenvironment. Additionally, migrasomes mediate viral spread. Migrasomes derived from macrophages can accelerate the progression of cardiovascular and cerebrovascular diseases by promoting neuroinflammation and neuronal damage. Meanwhile, migrasomes derived from podocytes serve as biomarkers for early kidney injury. Thus, elucidating the role of migrasomes in pathological processes and defining their specific functions holds great promise for developing novel therapeutic strategies for diseases. This review synthesizes current advances in migrasome biology, highlighting their potential as diagnostic biomarkers and therapeutic targets for conditions such as cancer, viral infections, and renal disorders.
Keywords: migrasomes, diseases, diagnosis and therapy, cell migration