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已发表论文
用于周围神经修复的先进纳米粒子工程平台：多模式治疗策略及临床转化
Authors Shi S , Yu X, Ou X, Zheng C, Xie F, Huang Y
Received 13 June 2025
Accepted for publication 25 September 2025
Published 2 October 2025 Volume 2025:20 Pages 12041—12056
DOI https://doi.org/10.2147/IJN.S547018
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Jie Huang
Shaoyan Shi,1 Xingxing Yu,2 Xuehai Ou,1 Changming Zheng,1 Fei Xie,1 Yansheng Huang3
1Department of Hand Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of China; 2Department of Laboratory Medicine, Xi’ an Medical College, Xi’an, Shaanxi, 710000, People’s Republic of China; 3Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of China
Correspondence: Yansheng Huang, Email yshg1991@163.com
Abstract: Peripheral nerve injuries (PNIs) remain a major clinical challenge, with current surgical interventions often falling short of restoring full function. Nanoparticle (NP)-engineered platforms are emerging as transformative tools in peripheral nerve repair by enabling multimodal therapeutic delivery, spatiotemporal control of the microenvironment, and biomimetic structural support. In this review, we summarize the recent advances in the design of inorganic, polymeric, and hybrid NPs that deliver neurotrophic factors, anti-inflammatory agents, and genetic material with high precision. Functionalization strategies—ranging from conductive and piezoelectric materials to antioxidant and immunomodulatory components—enable dynamic regulation of cellular behaviors critical for regeneration. Integration of NPs into next-generation scaffolds, including smart-responsive conduits and bioactive matrices, enhances axonal guidance and Schwann cell support. We further discuss preclinical outcomes demonstrating robust functional recovery and address translational barriers, including NP toxicity, scalable fabrication, and regulatory considerations. Finally, we outline future directions involving theranostic systems and AI-guided design for personalized nerve repair. Collectively, NP-engineered systems represent a paradigm shift in peripheral nerve regeneration, offering a multifaceted approach that bridges material science, bioengineering, and clinical translation.
Keywords: peripheral nerve injuries, nanoparticle, engineering, regeneration, translation
1Department of Hand Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of China; 2Department of Laboratory Medicine, Xi’ an Medical College, Xi’an, Shaanxi, 710000, People’s Republic of China; 3Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of China
Correspondence: Yansheng Huang, Email yshg1991@163.com
Abstract: Peripheral nerve injuries (PNIs) remain a major clinical challenge, with current surgical interventions often falling short of restoring full function. Nanoparticle (NP)-engineered platforms are emerging as transformative tools in peripheral nerve repair by enabling multimodal therapeutic delivery, spatiotemporal control of the microenvironment, and biomimetic structural support. In this review, we summarize the recent advances in the design of inorganic, polymeric, and hybrid NPs that deliver neurotrophic factors, anti-inflammatory agents, and genetic material with high precision. Functionalization strategies—ranging from conductive and piezoelectric materials to antioxidant and immunomodulatory components—enable dynamic regulation of cellular behaviors critical for regeneration. Integration of NPs into next-generation scaffolds, including smart-responsive conduits and bioactive matrices, enhances axonal guidance and Schwann cell support. We further discuss preclinical outcomes demonstrating robust functional recovery and address translational barriers, including NP toxicity, scalable fabrication, and regulatory considerations. Finally, we outline future directions involving theranostic systems and AI-guided design for personalized nerve repair. Collectively, NP-engineered systems represent a paradigm shift in peripheral nerve regeneration, offering a multifaceted approach that bridges material science, bioengineering, and clinical translation.
Keywords: peripheral nerve injuries, nanoparticle, engineering, regeneration, translation