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已发表论文
泛素 - 蛋白酶体系统：心肌炎致扩张型心肌病的关键调控枢纽
Authors Yin X, Wang D, Lyu J, Ding J, Pan Z, Wang K, Guo X
Received 18 May 2025
Accepted for publication 22 September 2025
Published 1 October 2025 Volume 2025:18 Pages 13555—13574
DOI https://doi.org/10.2147/JIR.S541274
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Durga Prasanna Misra
Xiang Yin, Dongfei Wang, Jialan Lyu, Jie Ding, Zhicheng Pan, Kai Wang, Xiaogang Guo
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
Correspondence: Xiaogang Guo, Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, People’s Republic of China, Email gxg22222@zju.edu.cn
Abstract: The ubiquitin-proteasome system (UPS), a key regulator of protein quality control essential for maintaining normal biological processes, also plays a vital role in cardiomyopathy. Myocarditis, a myocardial inflammatory disease characterized by chronic inflammation and immune activation, can progress to secondary dilated cardiomyopathy (DCM). Inflammatory DCM is further defined by structural and functional myocardial dysfunction and immune system dysregulation. Given its role in modulating the immune system, the UPS is critical to this transition from myocarditis to DCM. This review focuses primarily on viral myocarditis, summarizing findings on the UPS’s role in inflammation and its contribution to the progression to DCM in both animal models and human studies. We delve into the intricate involvement of the UPS in various processes, including virus replication, host protein degradation, pattern recognition receptor (PRR) signaling, and both innate and adaptive immunity. The molecular mechanisms underlying their context-dependent regulatory duality-wherein individual UPS components exert opposing inhibitory or activating effects across the progression from viral myocarditis to DCM-are elucidated and discussed. Targeting the UPS to ameliorate inflammation offers a potential therapeutic strategy for myocarditis and secondary DCM.
Keywords: ubiquitin-proteasome system, myocarditis, inflammatory dilated cardiomyopathy, inflammation, virus
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
Correspondence: Xiaogang Guo, Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, People’s Republic of China, Email gxg22222@zju.edu.cn
Abstract: The ubiquitin-proteasome system (UPS), a key regulator of protein quality control essential for maintaining normal biological processes, also plays a vital role in cardiomyopathy. Myocarditis, a myocardial inflammatory disease characterized by chronic inflammation and immune activation, can progress to secondary dilated cardiomyopathy (DCM). Inflammatory DCM is further defined by structural and functional myocardial dysfunction and immune system dysregulation. Given its role in modulating the immune system, the UPS is critical to this transition from myocarditis to DCM. This review focuses primarily on viral myocarditis, summarizing findings on the UPS’s role in inflammation and its contribution to the progression to DCM in both animal models and human studies. We delve into the intricate involvement of the UPS in various processes, including virus replication, host protein degradation, pattern recognition receptor (PRR) signaling, and both innate and adaptive immunity. The molecular mechanisms underlying their context-dependent regulatory duality-wherein individual UPS components exert opposing inhibitory or activating effects across the progression from viral myocarditis to DCM-are elucidated and discussed. Targeting the UPS to ameliorate inflammation offers a potential therapeutic strategy for myocarditis and secondary DCM.
Keywords: ubiquitin-proteasome system, myocarditis, inflammatory dilated cardiomyopathy, inflammation, virus