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已发表论文
类白血病反应与早期宫颈癌并发突发性听力损失：1 例报告并文献复习
Authors Feng S, Yin Y, Guo H, Li D
Received 2 May 2025
Accepted for publication 19 September 2025
Published 1 October 2025 Volume 2025:17 Pages 3417—3422
DOI https://doi.org/10.2147/IJWH.S528509
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Shuai Feng,1,2 Yueju Yin,1 Hui Guo,1 Dapeng Li1
1Department of Gynecological Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of China; 2The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China
Correspondence: Dapeng Li, Email drldp@126.com
Background: The manifestation of a leukemoid reaction in the cervical cancer is an uncommon occurrence. Three cases of advanced, recurrent or metastatic cervical cancer with leukoid reaction have been reported in the past, but no early cervical cancer with leukoid reaction has been reported. Paraneoplastic neurological syndromes (PNS) are rare and have not been reported in cervical cancer.
Case Presentation: A 38-year-old woman presented was admitted to hospital because of sudden hearing loss in her right ear, and routine blood tests showed abnormally elevated white blood cells and neutrophils (WBC: 43.87*109/L, NEU: 39.63× 10^9/L). Cervical biopsy and pathological examination revealed cervical squamous cell carcinoma. Infection and hematological diseases such as leukemia and bone marrow metastasis were ruled out. After operation WBC and NEU counts decreased and remained at normal levels and the hearing condition of her right ear was significantly improved than before. No leukopenic drugs or neurotrophic agents that improve hearing were used during the treatment period.
Conclusion: This is the first case of cervical cancer presenting with sudden deafness and the first case report of early cervical cancer complicated by a leukemoid reaction, which may be related to a paraneoplastic neurological syndrome.
Keywords: leukemoid reaction, paraneoplastic neurologic syndrome, cervical cancer
1Department of Gynecological Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of China; 2The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China
Correspondence: Dapeng Li, Email drldp@126.com
Background: The manifestation of a leukemoid reaction in the cervical cancer is an uncommon occurrence. Three cases of advanced, recurrent or metastatic cervical cancer with leukoid reaction have been reported in the past, but no early cervical cancer with leukoid reaction has been reported. Paraneoplastic neurological syndromes (PNS) are rare and have not been reported in cervical cancer.
Case Presentation: A 38-year-old woman presented was admitted to hospital because of sudden hearing loss in her right ear, and routine blood tests showed abnormally elevated white blood cells and neutrophils (WBC: 43.87*109/L, NEU: 39.63× 10^9/L). Cervical biopsy and pathological examination revealed cervical squamous cell carcinoma. Infection and hematological diseases such as leukemia and bone marrow metastasis were ruled out. After operation WBC and NEU counts decreased and remained at normal levels and the hearing condition of her right ear was significantly improved than before. No leukopenic drugs or neurotrophic agents that improve hearing were used during the treatment period.
Conclusion: This is the first case of cervical cancer presenting with sudden deafness and the first case report of early cervical cancer complicated by a leukemoid reaction, which may be related to a paraneoplastic neurological syndrome.
Keywords: leukemoid reaction, paraneoplastic neurologic syndrome, cervical cancer