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已发表论文
溴结构域和额外末端蛋白抑制：关节炎治疗的新策略
Authors Sheng W , Zhao J, Yu F, Wang D, Zeng H, Liu P
Received 17 April 2025
Accepted for publication 22 September 2025
Published 30 September 2025 Volume 2025:18 Pages 13503—13517
DOI https://doi.org/10.2147/JIR.S535057
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Yan Chen
Weibei Sheng,1 Jin Zhao,1 Fei Yu,2 Deli Wang,1 Hui Zeng,3,* Peng Liu1,*
1Department of Bone & Joint Surgery, Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China; 2Department of Spine Surgery, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People’s Republic of China; 3Department of Orthopedic Trauma, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hui Zeng, Email zenghui_36@163.com Peng Liu, Email liupeng@pkuszh.com
Abstract: Arthritis is an inflammatory condition that affects the joints and surrounding tissues, triggered by factors such as inflammation, infection, degeneration, and trauma. The major forms of arthritis include osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA). Its pathogenesis primarily involves synovial inflammation, cartilage degradation, and subchondral bone remodeling, with pro-inflammatory cytokines, collagenases, and other mediators playing central roles in disease onset and progression. The bromodomain and extraterminal (BET) protein family-a subclass of the larger bromodomain protein superfamily-comprises BRD2, BRD3, BRD4, and BRDT. The regulatory functions of BET proteins in inflammation highlight their considerable potential for mitigating arthritis-related pathology. This review provides a comprehensive overview of recent research on the role of BET proteins in OA, RA, and GA, aiming to deepen our understanding of the protective mechanisms of BET inhibitors, underscore their potential as therapeutic targets, and emphasize their relevance in the development of novel treatment strategies.
Keywords: arthritis, osteoarthritis, rheumatoid arthritis, gouty arthritis, bromodomain and extraterminal protein
1Department of Bone & Joint Surgery, Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China; 2Department of Spine Surgery, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People’s Republic of China; 3Department of Orthopedic Trauma, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hui Zeng, Email zenghui_36@163.com Peng Liu, Email liupeng@pkuszh.com
Abstract: Arthritis is an inflammatory condition that affects the joints and surrounding tissues, triggered by factors such as inflammation, infection, degeneration, and trauma. The major forms of arthritis include osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA). Its pathogenesis primarily involves synovial inflammation, cartilage degradation, and subchondral bone remodeling, with pro-inflammatory cytokines, collagenases, and other mediators playing central roles in disease onset and progression. The bromodomain and extraterminal (BET) protein family-a subclass of the larger bromodomain protein superfamily-comprises BRD2, BRD3, BRD4, and BRDT. The regulatory functions of BET proteins in inflammation highlight their considerable potential for mitigating arthritis-related pathology. This review provides a comprehensive overview of recent research on the role of BET proteins in OA, RA, and GA, aiming to deepen our understanding of the protective mechanisms of BET inhibitors, underscore their potential as therapeutic targets, and emphasize their relevance in the development of novel treatment strategies.
Keywords: arthritis, osteoarthritis, rheumatoid arthritis, gouty arthritis, bromodomain and extraterminal protein