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已发表论文
p11（S100A10）和下丘脑 - 垂体 - 肾上腺轴（HPA）稳态的紊乱参与了重度抑郁症（MDD）的发生，尤其在女性患者中
Authors Yue Y, Zhang J, Li Y, Ma X, Chen G, Zhu Z, Chen S , Chen Y, You L, Tan L, Jiang W, Yuan Y
Received 25 June 2025
Accepted for publication 18 September 2025
Published 30 September 2025 Volume 2025:21 Pages 2237—2249
DOI https://doi.org/10.2147/NDT.S549538
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Yu-Ping Ning
Yingying Yue,1,* Jialin Zhang,2,* Yinghui Li,1 Xuxia Ma,1 Gang Chen,1 Zixin Zhu,1 Suzhen Chen,1 Ying Chen,1 Linlin You,1 Liangliang Tan,1 Wenhao Jiang,1 Yonggui Yuan1
1Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Department of Psychiatry, Binzhou People’s Hospital, Binzhou, 256600, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yonggui Yuan, Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, 210009, People’s Republic of China, Tel +0086-025-83285124, Email yygylh2000@sina.com
Objective: Patients suffering from major depressive disorder (MDD) commonly exhibit abnormal p11 (S100A10) and dysregulation of the hypothalamic–pituitary–adrenocortical (HPA) axis. This study was aimed to quantify peripheral p11, cortisol (COR), and adrenocorticotropic hormone (ACTH) levels and further revealed the possible mechanisms of MDD and antidepressant response.
Methods: A total of 60 MDD inpatients and 67 healthy controls (HC) were recruited in this study. Demographic characteristics and neuropsychological assessment including Hamilton rating scale for depression-17 (HAMD-17), Hamilton anxiety rating scale (HAMA), Snaith-Hamilton pleasure scale (SHAPS) and temporal experience of pleasure scale (TEPS) were collected. A main antidepressant was utilized after the patients were enrolled (T0) and at two week follow-up (T2). Peripheral p11 levels including monocyte (MO), natural killer (NK), T-cell, COR, and ACTH were measured by multicolor flow cytometry and enzyme-linked immunosorbent assay at T0 and T2.
Results: CD4+T p11, COR and ACTH were significantly different between the MDD and HC groups at T0 (all P < 0.05). Subgroup analysis by gender showed that the MO-C, MO-NC, and NK p11+ cells were higher in female than in male MDD patients (all P < 0.05). There was a negative relationship between p11 of MO-NC, CD4+T, CD8+T, and TEPS. However, there was no significant difference between T0 and T2 in MDD patients.
Conclusion: Baseline p11 levels may serve as a peripheral blood biomarker for female depressive patients and further provide more insight into the pathological mechanisms of MDD.
Keywords: major depressive disorder, p11, cortisol, adrenocorticotropic hormone
1Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Department of Psychiatry, Binzhou People’s Hospital, Binzhou, 256600, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yonggui Yuan, Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, 210009, People’s Republic of China, Tel +0086-025-83285124, Email yygylh2000@sina.com
Objective: Patients suffering from major depressive disorder (MDD) commonly exhibit abnormal p11 (S100A10) and dysregulation of the hypothalamic–pituitary–adrenocortical (HPA) axis. This study was aimed to quantify peripheral p11, cortisol (COR), and adrenocorticotropic hormone (ACTH) levels and further revealed the possible mechanisms of MDD and antidepressant response.
Methods: A total of 60 MDD inpatients and 67 healthy controls (HC) were recruited in this study. Demographic characteristics and neuropsychological assessment including Hamilton rating scale for depression-17 (HAMD-17), Hamilton anxiety rating scale (HAMA), Snaith-Hamilton pleasure scale (SHAPS) and temporal experience of pleasure scale (TEPS) were collected. A main antidepressant was utilized after the patients were enrolled (T0) and at two week follow-up (T2). Peripheral p11 levels including monocyte (MO), natural killer (NK), T-cell, COR, and ACTH were measured by multicolor flow cytometry and enzyme-linked immunosorbent assay at T0 and T2.
Results: CD4+T p11, COR and ACTH were significantly different between the MDD and HC groups at T0 (all P < 0.05). Subgroup analysis by gender showed that the MO-C, MO-NC, and NK p11+ cells were higher in female than in male MDD patients (all P < 0.05). There was a negative relationship between p11 of MO-NC, CD4+T, CD8+T, and TEPS. However, there was no significant difference between T0 and T2 in MDD patients.
Conclusion: Baseline p11 levels may serve as a peripheral blood biomarker for female depressive patients and further provide more insight into the pathological mechanisms of MDD.
Keywords: major depressive disorder, p11, cortisol, adrenocorticotropic hormone