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已发表论文
关于睡眠与尿酸代谢调节的分子及临床视角
Authors Ha G , Wu J, Hu J, Wang X, Xie Y, Zhao Z, Cai D
Received 11 June 2025
Accepted for publication 15 September 2025
Published 30 September 2025 Volume 2025:17 Pages 2321—2340
DOI https://doi.org/10.2147/NSS.S545905
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Sarah L Appleton
Guodong Ha, Jiawei Wu, Jing Hu, Xun Wang, Yijie Xie, Zhengyu Zhao, Dingjun Cai
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, People’s Republic of China
Correspondence: Dingjun Cai, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No. 37 Shierqiao Road, Jinniu District, Chengdu, Sichuan, People’s Republic of China, Email djcai@cdutcm.edu.cn
Abstract: Uric acid, the end product of purine metabolism, is closely associated with metabolic disorders, including gout and metabolic syndrome. Emerging evidence highlights a bidirectional relationship between uric acid metabolism and sleep regulation. Elevated uric acid levels can adversely affect sleep quality via oxidative stress and neuroinflammatory pathways, while sleep deprivation may promote uric acid synthesis and impair its excretion. This reciprocal interaction may form a vicious cycle, potentially accelerating the onset and progression of various metabolic diseases. This review summarizes recent clinical and experimental findings, focusing on the molecular mechanisms underlying the bidirectional regulation between uric acid metabolism and sleep. The implications of this relationship in the pathophysiology of metabolic disorders are discussed. Understanding this interplay underscores the importance of targeting uric acid levels and sleep quality as integrated strategies for managing metabolic diseases. These insights provide a foundation for the development of novel therapeutic interventions designed to enhance clinical outcomes in metabolic syndrome.
Keywords: uric acid metabolism, sleep, bidirectional regulation, metabolic disease
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, People’s Republic of China
Correspondence: Dingjun Cai, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No. 37 Shierqiao Road, Jinniu District, Chengdu, Sichuan, People’s Republic of China, Email djcai@cdutcm.edu.cn
Abstract: Uric acid, the end product of purine metabolism, is closely associated with metabolic disorders, including gout and metabolic syndrome. Emerging evidence highlights a bidirectional relationship between uric acid metabolism and sleep regulation. Elevated uric acid levels can adversely affect sleep quality via oxidative stress and neuroinflammatory pathways, while sleep deprivation may promote uric acid synthesis and impair its excretion. This reciprocal interaction may form a vicious cycle, potentially accelerating the onset and progression of various metabolic diseases. This review summarizes recent clinical and experimental findings, focusing on the molecular mechanisms underlying the bidirectional regulation between uric acid metabolism and sleep. The implications of this relationship in the pathophysiology of metabolic disorders are discussed. Understanding this interplay underscores the importance of targeting uric acid levels and sleep quality as integrated strategies for managing metabolic diseases. These insights provide a foundation for the development of novel therapeutic interventions designed to enhance clinical outcomes in metabolic syndrome.
Keywords: uric acid metabolism, sleep, bidirectional regulation, metabolic disease