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已发表论文
宫颈癌术后淋巴水肿危险因素分析：一项病例对照回顾性研究
Authors Gu X, Luo Y, Lai C, Liu Y
Received 30 April 2025
Accepted for publication 19 September 2025
Published 30 September 2025 Volume 2025:18 Pages 5927—5938
DOI https://doi.org/10.2147/IJGM.S537679
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Dana Kristjansson
Xiufen Gu,1 Yu Luo,1 Cuiwei Lai,2 Yun Liu3
1Department of Gynecology, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 2Nursing Department, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 3Department of Medical Oncology, Meizhou People’s Hospital, Meizhou, People’s Republic of China
Correspondence: Xiufen Gu, Department of Gynecology, Meizhou People’s Hospital, Meizhou, People’s Republic of China, Email 13723629964@126.com
Objective: Cervical cancer is a common malignant tumor in the female reproductive system, surgery is the main radical treatment methods. Lymphedema, as a postoperative complication of cervical cancer, affects the prognosis of patients. Identifying the risk factors for lymphedema after surgery is of great clinical significance for reducing its incidence. This study aims to systematically analyze the related risk factors for lymphedema after cervical cancer surgery.
Methods: Clinical medical data of 701 cervical cancer patients at Meizhou People’s Hospital from December 2018 to December 2023 were collected, including age, body mass index (BMI), hypertension, diabetes mellitus, induced abortion, menopause, clinical stage, number of dissected lymph nodes, lymph node metastasis, postoperative complications, postoperative chemotherapy, postoperative radiotherapy, postoperative living habits, and lymphedema. The relationship between lymphedema and clinical features in cervical cancer was analyzed.
Results: A total of 220 (31.4%) patients developed lymphedema and 481 (68.6%) did not. The cervical cancer patients with lymphedema had higher proportions of advanced age, hypertension, menopause, number of dissected lymph nodes≥ 30, postoperative radiotherapy, and sitting quietly> 1 hour every day than patients without lymphedema. Logistic regression analysis showed that advanced age (odds ratio (OR): 2.713, 95% confidence interval (CI): 1.560– 4.717, p< 0.001), menopause (OR: 1.954, 95% CI: 1.091– 3.501, p=0.024), pelvic lymph nodes plus para-aortic lymph nodes plus inguinal lymph nodes were dissected (OR: 2.039, 95% CI: 1.297– 3.207, p=0.002), number of dissected lymph nodes (≥ 30 vs < 30, OR: 1.666, 95% CI: 1.105– 2.514, p=0.015), postoperative radiotherapy (OR: 3.775, 95% CI: 2.348– 6.069, p< 0.001), and sitting quietly> 1 hour every day (OR: 14.782, 95% CI: 7.926– 27.567, p< 0.001) were associated with lymphedema in cervical cancer.
Conclusion: Advanced age, menopause, pelvic lymph nodes plus para-aortic lymph nodes plus inguinal lymph nodes were dissected, number of dissected lymph nodes, postoperative complications, postoperative radiotherapy, and sitting quietly every day were independently associated with lymphedema in cervical cancer patients.
Keywords: cervical cancer, lymphedema, risk factors, clinical features
1Department of Gynecology, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 2Nursing Department, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 3Department of Medical Oncology, Meizhou People’s Hospital, Meizhou, People’s Republic of China
Correspondence: Xiufen Gu, Department of Gynecology, Meizhou People’s Hospital, Meizhou, People’s Republic of China, Email 13723629964@126.com
Objective: Cervical cancer is a common malignant tumor in the female reproductive system, surgery is the main radical treatment methods. Lymphedema, as a postoperative complication of cervical cancer, affects the prognosis of patients. Identifying the risk factors for lymphedema after surgery is of great clinical significance for reducing its incidence. This study aims to systematically analyze the related risk factors for lymphedema after cervical cancer surgery.
Methods: Clinical medical data of 701 cervical cancer patients at Meizhou People’s Hospital from December 2018 to December 2023 were collected, including age, body mass index (BMI), hypertension, diabetes mellitus, induced abortion, menopause, clinical stage, number of dissected lymph nodes, lymph node metastasis, postoperative complications, postoperative chemotherapy, postoperative radiotherapy, postoperative living habits, and lymphedema. The relationship between lymphedema and clinical features in cervical cancer was analyzed.
Results: A total of 220 (31.4%) patients developed lymphedema and 481 (68.6%) did not. The cervical cancer patients with lymphedema had higher proportions of advanced age, hypertension, menopause, number of dissected lymph nodes≥ 30, postoperative radiotherapy, and sitting quietly> 1 hour every day than patients without lymphedema. Logistic regression analysis showed that advanced age (odds ratio (OR): 2.713, 95% confidence interval (CI): 1.560– 4.717, p< 0.001), menopause (OR: 1.954, 95% CI: 1.091– 3.501, p=0.024), pelvic lymph nodes plus para-aortic lymph nodes plus inguinal lymph nodes were dissected (OR: 2.039, 95% CI: 1.297– 3.207, p=0.002), number of dissected lymph nodes (≥ 30 vs < 30, OR: 1.666, 95% CI: 1.105– 2.514, p=0.015), postoperative radiotherapy (OR: 3.775, 95% CI: 2.348– 6.069, p< 0.001), and sitting quietly> 1 hour every day (OR: 14.782, 95% CI: 7.926– 27.567, p< 0.001) were associated with lymphedema in cervical cancer.
Conclusion: Advanced age, menopause, pelvic lymph nodes plus para-aortic lymph nodes plus inguinal lymph nodes were dissected, number of dissected lymph nodes, postoperative complications, postoperative radiotherapy, and sitting quietly every day were independently associated with lymphedema in cervical cancer patients.
Keywords: cervical cancer, lymphedema, risk factors, clinical features