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已发表论文
硅基纳米材料在慢性伤口愈合中的作用：机制、治疗应用及临床前景
Authors Zhao X, Xu Z, Wang D, Li T, Li Z, Bai X, Zhu H, Liu Y, Wang Y
Received 15 March 2025
Accepted for publication 18 September 2025
Published 30 September 2025 Volume 2025:20 Pages 11959—11988
DOI https://doi.org/10.2147/IJN.S528531
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. RDK Misra
Xuan Zhao,1– 4 Zhikai Xu,1– 4 Dongfang Wang,1– 4 Tonghan Li,1– 4 Zhanfei Li,1– 4 Xiangjun Bai,1– 4 Hao Zhu,5 Yukun Liu,6 Yuchang Wang1– 4
1Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Trauma Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 3Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 4Sino-German Research Institute of Disaster Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 5Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 6Department of Plastic and Aesthetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China
Correspondence: Yukun Liu; Yuchang Wang, Email annine.liu1989@gmail.com; tjwangyuchang@163.com
Abstract: Silicon-based nanosystems are emerging as promising nanotherapeutic platforms in the biomedical field, particularly for the treatment of chronic wounds. These materials possess several advantageous features. They offer excellent drug-loading capacity, controlled and stimuli-responsive drug release, and highly customizable structures and functions. These characteristics make them well-suited for personalized therapeutic approaches.This review provides a comprehensive summary of recent advances in the application of silicon-based nanosystems in wound healing. It highlights their mechanisms of action and discusses future development directions. We begin by outlining the clinical significance and complex pathophysiological characteristics of chronic wounds. A detailed classification of silicon-based nanomaterials is then provided, including mesoporous silica nanoparticles and silicon-based composites. The review emphasizes their key roles in modulating inflammation, reducing oxidative stress, and promoting angiogenesis and tissue regeneration. In addition, we summarize recent findings from in vitro and in vivo studies, as well as updates from relevant clinical research. The biocompatibility and safety profiles of these systems are also comprehensively evaluated. Future research should focus on optimizing the synthesis of these materials and improving their long-term biosafety. Efforts should also aim to integrate multifunctional therapeutic strategies to enhance efficacy and translational potential. Moreover, large-scale, rigorously designed clinical trials are urgently needed. These studies will help build robust clinical evidence and support the practical application of silicon-based nanosystems in advanced wound care. In conclusion, silicon-based nanosystems represent a next-generation approach for wound therapy. However, further interdisciplinary research is essential to fully realize their clinical value.
Keywords: silicon, nanomaterial, chronic wound healing, wound healing, silicon-based nanosystems
1Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Trauma Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 3Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 4Sino-German Research Institute of Disaster Medicine, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 5Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 6Department of Plastic and Aesthetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China
Correspondence: Yukun Liu; Yuchang Wang, Email annine.liu1989@gmail.com; tjwangyuchang@163.com
Abstract: Silicon-based nanosystems are emerging as promising nanotherapeutic platforms in the biomedical field, particularly for the treatment of chronic wounds. These materials possess several advantageous features. They offer excellent drug-loading capacity, controlled and stimuli-responsive drug release, and highly customizable structures and functions. These characteristics make them well-suited for personalized therapeutic approaches.This review provides a comprehensive summary of recent advances in the application of silicon-based nanosystems in wound healing. It highlights their mechanisms of action and discusses future development directions. We begin by outlining the clinical significance and complex pathophysiological characteristics of chronic wounds. A detailed classification of silicon-based nanomaterials is then provided, including mesoporous silica nanoparticles and silicon-based composites. The review emphasizes their key roles in modulating inflammation, reducing oxidative stress, and promoting angiogenesis and tissue regeneration. In addition, we summarize recent findings from in vitro and in vivo studies, as well as updates from relevant clinical research. The biocompatibility and safety profiles of these systems are also comprehensively evaluated. Future research should focus on optimizing the synthesis of these materials and improving their long-term biosafety. Efforts should also aim to integrate multifunctional therapeutic strategies to enhance efficacy and translational potential. Moreover, large-scale, rigorously designed clinical trials are urgently needed. These studies will help build robust clinical evidence and support the practical application of silicon-based nanosystems in advanced wound care. In conclusion, silicon-based nanosystems represent a next-generation approach for wound therapy. However, further interdisciplinary research is essential to fully realize their clinical value.
Keywords: silicon, nanomaterial, chronic wound healing, wound healing, silicon-based nanosystems