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已发表论文
电针疗法可减少腹部肥胖患者的腰围：一项随机对照试验及脂质组学和肠道菌群机制分析
Authors Chen X , Zhang Y, Fu C, Huang M, Wei D, Zhou W, Liu Y, Huang B, Rao Y, Zhang Y, Xia H, Hu Y, Li H, Huang W , Zhou Z
Received 8 July 2025
Accepted for publication 14 September 2025
Published 30 September 2025 Volume 2025:18 Pages 3649—3669
DOI https://doi.org/10.2147/DMSO.S551806
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Donald McClain
Xia Chen,1– 4 Yanji Zhang,1– 4 Chengwei Fu,1– 4 Mengyuan Huang,5 Dan Wei,1– 4 Wei Zhou,1– 4 Yiran Liu,1– 4 Bei Huang,1– 4 Yingyue Rao,5 Yingrong Zhang,5 Hongjie Xia,5 Yaxin Hu,5 Hui Li,6 Wei Huang,1– 4 Zhongyu Zhou1– 4
1Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China; 2Hubei Shizhen Laboratory, Wuhan, People’s Republic of China; 3Department of Acupuncture, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, People’s Republic of China; 4Hubei Provincial Clinical Research Center for Acupuncture and Moxibustion in Obesity Treatment, Wuhan, People’s Republic of China; 5College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, People’s Republic of China; 6Medical Department, Taixing People’s Hospital, Taixing, People’s Republic of China
Correspondence: Zhongyu Zhou, Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, No. 4, Huayanshan, Wuhan, People’s Republic of China, Email 2209447940@qq.com Wei Huang, Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, No. 4, Huayanshan, Wuhan, People’s Republic of China, Email 24231637@qq.com
Background: Abdominal obesity is a major risk factor for metabolic diseases and certain cancers. Although lifestyle intervention is the cornerstone of treatment, maintaining weight reduction is challenging. Electroacupuncture (EA) has shown potential in improving abdominal obesity, but its underlying mechanisms remain unclear.
Objective: This randomized controlled trial evaluates the efficacy of electroacupuncture combined with lifestyle intervention for reducing waist circumference in adults with abdominal obesity, and explores potential mechanisms through lipidomics and intestinal microbiota analyses.
Methods: The studies were performed in Hubei Provincial Hospital of Traditional Chinese Medicine between July 2020 and March 2023. Sixty-eight patients with abdominal obesity and 34 matched – healthy controls (HC) were recruited. After randomization, patients with abdominal obesity received an 8-week EA treatment or sham electroacupuncture (SA) treatment followed by 24-week follow-up. The change of waistline was to evaluate the efficacy of EA. Serum and stool specimen of EA group (pre- and post-treatment) and HC were collected for lipid metabolism markers and intestinal microbiota analysis.
Results: Compared with baseline, the difference of waistline between EA and SA was 7.38 (95% CI, 2.88 to 11.87; P = 0.002) cm at the end of treatment (week 8) and 8.99 (95% CI, 4.48 to 13.50; P < 0.001) cm at the end of follow-up (week 32), respectively. Lipidomic analysis indicated that some lipid species previously found to differ between patients with abdominal obesity and healthy controls showed a trend toward reversal after EA treatment. Microbiota analysis showed that EA did not significantly alter overall richness, but the abundance of certain taxa changed, particularly Akkermansia muciniphila.
Trial Registration: ClinicalTrials, NCT04957134. Registered 30 June 2021, https://clinicaltrials.gov/study/NCT04957134?term=NCT04957134&rank=1.
Conclusion: Our findings suggest that electroacupuncture is effective and safe in reducing waistline in patients with abdominal obesity. These results provide preliminary evidence that its benefits may be related to changes in lipid metabolism and intestinal microbiota, although further studies are warranted.
Keywords: electroacupuncture, abdominal obesity, intestinal microbiota, lipidomics, randomized controlled trail
1Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China; 2Hubei Shizhen Laboratory, Wuhan, People’s Republic of China; 3Department of Acupuncture, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, People’s Republic of China; 4Hubei Provincial Clinical Research Center for Acupuncture and Moxibustion in Obesity Treatment, Wuhan, People’s Republic of China; 5College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, People’s Republic of China; 6Medical Department, Taixing People’s Hospital, Taixing, People’s Republic of China
Correspondence: Zhongyu Zhou, Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, No. 4, Huayanshan, Wuhan, People’s Republic of China, Email 2209447940@qq.com Wei Huang, Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, No. 4, Huayanshan, Wuhan, People’s Republic of China, Email 24231637@qq.com
Background: Abdominal obesity is a major risk factor for metabolic diseases and certain cancers. Although lifestyle intervention is the cornerstone of treatment, maintaining weight reduction is challenging. Electroacupuncture (EA) has shown potential in improving abdominal obesity, but its underlying mechanisms remain unclear.
Objective: This randomized controlled trial evaluates the efficacy of electroacupuncture combined with lifestyle intervention for reducing waist circumference in adults with abdominal obesity, and explores potential mechanisms through lipidomics and intestinal microbiota analyses.
Methods: The studies were performed in Hubei Provincial Hospital of Traditional Chinese Medicine between July 2020 and March 2023. Sixty-eight patients with abdominal obesity and 34 matched – healthy controls (HC) were recruited. After randomization, patients with abdominal obesity received an 8-week EA treatment or sham electroacupuncture (SA) treatment followed by 24-week follow-up. The change of waistline was to evaluate the efficacy of EA. Serum and stool specimen of EA group (pre- and post-treatment) and HC were collected for lipid metabolism markers and intestinal microbiota analysis.
Results: Compared with baseline, the difference of waistline between EA and SA was 7.38 (95% CI, 2.88 to 11.87; P = 0.002) cm at the end of treatment (week 8) and 8.99 (95% CI, 4.48 to 13.50; P < 0.001) cm at the end of follow-up (week 32), respectively. Lipidomic analysis indicated that some lipid species previously found to differ between patients with abdominal obesity and healthy controls showed a trend toward reversal after EA treatment. Microbiota analysis showed that EA did not significantly alter overall richness, but the abundance of certain taxa changed, particularly Akkermansia muciniphila.
Trial Registration: ClinicalTrials, NCT04957134. Registered 30 June 2021, https://clinicaltrials.gov/study/NCT04957134?term=NCT04957134&rank=1.
Conclusion: Our findings suggest that electroacupuncture is effective and safe in reducing waistline in patients with abdominal obesity. These results provide preliminary evidence that its benefits may be related to changes in lipid metabolism and intestinal microbiota, although further studies are warranted.
Keywords: electroacupuncture, abdominal obesity, intestinal microbiota, lipidomics, randomized controlled trail