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已发表论文
2 型糖尿病合并冠心病患者按血糖控制情况分层的脂质稳态标志物、炎症标志物与动脉粥样硬化指数之间的关联：一项横断面研究
Authors Yang P, Dai T, Liu B, Yin J, Li X, Zai W, Zhuang H
Received 27 June 2025
Accepted for publication 13 September 2025
Published 30 September 2025 Volume 2025:18 Pages 13453—13463
DOI https://doi.org/10.2147/JIR.S550135
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Qing Lin
Ping Yang,1,* Tian Dai,1,* Bo Liu,1 Jun Yin,1 Xiaoli Li,1 Wenxin Zai,1 Hong Zhuang2
1Department of Cardiology, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, People’s Republic of China; 2Department of Physical Examination, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hong Zhuang, Department of Physical Examination, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, No. 168 Hong Kong Road, Jiang’an District, Wuhan, Hubei, 430000, People’s Republic of China, Tel +86 027 82441147, Email juney622@126.com
Objective: This cross-sectional study investigates the relationship between systemic markers of lipid homeostasis, inflammation, and atherosclerosis index (AI) in patients with both type 2 diabetes and coronary heart disease (CHD), stratified by their glycemic control status.
Methods: A total of 120 patients with type 2 diabetes and CHD were included and stratified into a Good Glycemic Control group (GGC, HbA1c< 7%, n=72) and a Poor Glycemic Control group (PGC, HbA1c≥ 7%, n=48). AI was assessed using brachial-ankle pulse wave velocity (baPWV), and coronary stenosis was evaluated angiographically. Blood lipids, glucose metabolism indicators (Fasting Plasma Glucose [FPG], Fasting Insulin [FINS], HOMA-IR), and serum inflammatory markers (TNF-α, IL-1β, hs-CRP) were quantified. Pearson correlation and logistic regression analyses were used to assess associations and identify risk factors for AI.
Results: The PGC group exhibited significantly higher AI and coronary stenosis scores, a more atherogenic lipid profile (higher TC, TG, LDL-C; lower HDL-C), and elevated HOMA-IR and inflammatory markers compared to the GGC group (all P< 0.05). Baseline characteristics and medication use were similar, except for higher insulin use in the PGC group. Pearson analysis revealed that AI was positively correlated with hs-CRP, TG, coronary stenosis scores, and HOMA-IR (all P< 0.05). Logistic regression identified hs-CRP, TG, coronary stenosis score, and HOMA-IR as independent risk factors for increased AI.
Conclusion: In patients with type 2 diabetes and CHD, poor glycemic control is strongly associated with increased arterial stiffness, dyslipidemia, systemic inflammation, and insulin resistance. These findings highlight the critical, intertwined roles of these pathways in atherosclerosis and underscore the necessity of a multifactorial approach to cardiovascular risk management in this high-risk population.
Keywords: diabetes, coronary heart disease, lipid homeostasis, atherosclerosis, glycemic control, inflammation
1Department of Cardiology, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, People’s Republic of China; 2Department of Physical Examination, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hong Zhuang, Department of Physical Examination, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, No. 168 Hong Kong Road, Jiang’an District, Wuhan, Hubei, 430000, People’s Republic of China, Tel +86 027 82441147, Email juney622@126.com
Objective: This cross-sectional study investigates the relationship between systemic markers of lipid homeostasis, inflammation, and atherosclerosis index (AI) in patients with both type 2 diabetes and coronary heart disease (CHD), stratified by their glycemic control status.
Methods: A total of 120 patients with type 2 diabetes and CHD were included and stratified into a Good Glycemic Control group (GGC, HbA1c< 7%, n=72) and a Poor Glycemic Control group (PGC, HbA1c≥ 7%, n=48). AI was assessed using brachial-ankle pulse wave velocity (baPWV), and coronary stenosis was evaluated angiographically. Blood lipids, glucose metabolism indicators (Fasting Plasma Glucose [FPG], Fasting Insulin [FINS], HOMA-IR), and serum inflammatory markers (TNF-α, IL-1β, hs-CRP) were quantified. Pearson correlation and logistic regression analyses were used to assess associations and identify risk factors for AI.
Results: The PGC group exhibited significantly higher AI and coronary stenosis scores, a more atherogenic lipid profile (higher TC, TG, LDL-C; lower HDL-C), and elevated HOMA-IR and inflammatory markers compared to the GGC group (all P< 0.05). Baseline characteristics and medication use were similar, except for higher insulin use in the PGC group. Pearson analysis revealed that AI was positively correlated with hs-CRP, TG, coronary stenosis scores, and HOMA-IR (all P< 0.05). Logistic regression identified hs-CRP, TG, coronary stenosis score, and HOMA-IR as independent risk factors for increased AI.
Conclusion: In patients with type 2 diabetes and CHD, poor glycemic control is strongly associated with increased arterial stiffness, dyslipidemia, systemic inflammation, and insulin resistance. These findings highlight the critical, intertwined roles of these pathways in atherosclerosis and underscore the necessity of a multifactorial approach to cardiovascular risk management in this high-risk population.
Keywords: diabetes, coronary heart disease, lipid homeostasis, atherosclerosis, glycemic control, inflammation