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已发表论文
特定睡眠特征与四种炎症性皮肤病之间的关联：一项孟德尔随机化研究
Authors Yang P, Huang Y, He W, Chen T, Wei S, Zhao Y
Received 20 May 2025
Accepted for publication 15 September 2025
Published 29 September 2025 Volume 2025:18 Pages 2509—2521
DOI https://doi.org/10.2147/CCID.S541688
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Peiquan Yang,* Yongyou Huang,* Wencheng He, Tingjun Chen, Shenji Wei, Yuanqing Zhao
Department of Neurology, Guiping People’s Hospital, Guiping, Guangxi Zhuang Autonomous Region, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peiquan Yang, Email 13878098408@ymun.edu.cn
Background: Sleep disturbances, including insomnia and abnormal sleep duration, are increasingly recognized for their role in various inflammatory processes, yet their causal impact on inflammatory skin diseases remains unclear.
Objective: This study aims to systematically explore the causal relationships between specific 8 sleep traits and 4 inflammatory skin diseases, including psoriasis, acne, atopic dermatitis, and urticaria.
Methods: We conducted a two-sample Mendelian randomization (MR) analysis using genetic data from the UK Biobank and FinnGen. Genetic variants associated with the sleep traits, such as insomnia, sleep duration, daytime sleepiness, daytime napping, snoring, and chronotype, were selected as instrumental variables. We employed methods including inverse variance weighting, weighted median estimation, and MR Egger regression to ensure robust causal inference. Sensitivity analyses were conducted to assess heterogeneity and pleiotropy.
Results: Notably, frequent insomnia was causally linked to an increased risk of psoriasis and atopic dermatitis, while longer sleep duration showed protective effects against acne and urticaria. Additionally, there was no strong evidence connecting other sleep traits like daytime sleepiness, napping, snoring, and chronotype to these skin conditions. Sensitivity analyses also confirmed the robustness and consistency of these findings across different methods.
Conclusion: This study provides evidence that specific sleep traits, especially insomnia and sleep duration, have a causal impact on inflammatory skin diseases. Addressing sleep disturbances in dermatological care could be crucial for reducing disease severity and enhancing patient outcomes.
Keywords: Mendelian randomization, inflammatory skin diseases, sleep traits, causal inference, GWAS
Department of Neurology, Guiping People’s Hospital, Guiping, Guangxi Zhuang Autonomous Region, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peiquan Yang, Email 13878098408@ymun.edu.cn
Background: Sleep disturbances, including insomnia and abnormal sleep duration, are increasingly recognized for their role in various inflammatory processes, yet their causal impact on inflammatory skin diseases remains unclear.
Objective: This study aims to systematically explore the causal relationships between specific 8 sleep traits and 4 inflammatory skin diseases, including psoriasis, acne, atopic dermatitis, and urticaria.
Methods: We conducted a two-sample Mendelian randomization (MR) analysis using genetic data from the UK Biobank and FinnGen. Genetic variants associated with the sleep traits, such as insomnia, sleep duration, daytime sleepiness, daytime napping, snoring, and chronotype, were selected as instrumental variables. We employed methods including inverse variance weighting, weighted median estimation, and MR Egger regression to ensure robust causal inference. Sensitivity analyses were conducted to assess heterogeneity and pleiotropy.
Results: Notably, frequent insomnia was causally linked to an increased risk of psoriasis and atopic dermatitis, while longer sleep duration showed protective effects against acne and urticaria. Additionally, there was no strong evidence connecting other sleep traits like daytime sleepiness, napping, snoring, and chronotype to these skin conditions. Sensitivity analyses also confirmed the robustness and consistency of these findings across different methods.
Conclusion: This study provides evidence that specific sleep traits, especially insomnia and sleep duration, have a causal impact on inflammatory skin diseases. Addressing sleep disturbances in dermatological care could be crucial for reducing disease severity and enhancing patient outcomes.
Keywords: Mendelian randomization, inflammatory skin diseases, sleep traits, causal inference, GWAS