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已发表论文
2021 至 2024 年激素替代治疗周期中胚胎移植时间对第 6 天囊胚妊娠结局的影响
Authors Huang C, Xing J, Shi Q , Shen X, Yan Y, Jiang Y
Received 20 June 2025
Accepted for publication 25 September 2025
Published 29 September 2025 Volume 2025:18 Pages 5949—5957
DOI https://doi.org/10.2147/IJGM.S544906
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Chenyang Huang,1– 3,* Jun Xing,1– 3,* Qingqing Shi,1– 3 Xiaoyue Shen,1– 3 Yuan Yan,1– 3 Yue Jiang1– 3
1Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 2Center for Molecular Reproductive Medicine, Nanjing University, Nanjing, People’s Republic of China; 3Center for Reproductive Medicine and Obstetrics and Gynecology, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuan Yan; Yue Jiang, Email stefanieyan@163.com; jiangyue85@163.com
Background: The achievement of a healthy live birth from a singleton pregnancy has become the primary objective of modern Assisted Reproductive Technology (ART). Consequently, the effective utilization of a single blastocyst is of paramount importance. However, the optimal approach to improving clinical pregnancy rates for Day-6 (D6) blastocysts in the hormonal replacement therapy frozen embryo transfer (HRT-FET) cycle remains unclear.
Methods: This study retrospectively analyzed 990 D6 single blastocyst HRT-FET cycles conducted at the Reproductive Medicine Center of Nanjing Drum tower Hospital from January 2021 to April 2024. Patients were categorized based on the timing of embryo transfer (on the 6th or 7th day of progesterone administration), and both univariate and multivariate regression analyses were employed to assess the impact of transfer timing on clinical pregnancy outcomes.
Results: The results revealed no significant differences in baseline characteristics or treatment cycle parameters between the two groups based on transfer timing. Univariate analysis identified several factors, including the age of both partners, infertility etiology, anti-Müllerian hormone (AMH) levels, antral follicle count (AFC), and the number of prior ART cycles, which may influence clinical pregnancy outcomes. After adjusting for these variables, multivariate regression analysis indicated that the timing of endometrial preparation for D6 single blastocyst transfer did not significantly affect clinical pregnancy rates.
Conclusion: In conclusion, our retrospective data suggest that transferring single D6 blastocysts on either the sixth or seventh day of progesterone administration in HRT-FET cycles yields comparable clinical pregnancy outcomes. Until further prospective evidence emerges, our findings do not support routine delay of D6 blastocyst transfers in HRT cycles.
Keywords: day-6 blastocyst, HRT-FET, transfer timing, clinical pregnancy rate
1Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 2Center for Molecular Reproductive Medicine, Nanjing University, Nanjing, People’s Republic of China; 3Center for Reproductive Medicine and Obstetrics and Gynecology, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuan Yan; Yue Jiang, Email stefanieyan@163.com; jiangyue85@163.com
Background: The achievement of a healthy live birth from a singleton pregnancy has become the primary objective of modern Assisted Reproductive Technology (ART). Consequently, the effective utilization of a single blastocyst is of paramount importance. However, the optimal approach to improving clinical pregnancy rates for Day-6 (D6) blastocysts in the hormonal replacement therapy frozen embryo transfer (HRT-FET) cycle remains unclear.
Methods: This study retrospectively analyzed 990 D6 single blastocyst HRT-FET cycles conducted at the Reproductive Medicine Center of Nanjing Drum tower Hospital from January 2021 to April 2024. Patients were categorized based on the timing of embryo transfer (on the 6th or 7th day of progesterone administration), and both univariate and multivariate regression analyses were employed to assess the impact of transfer timing on clinical pregnancy outcomes.
Results: The results revealed no significant differences in baseline characteristics or treatment cycle parameters between the two groups based on transfer timing. Univariate analysis identified several factors, including the age of both partners, infertility etiology, anti-Müllerian hormone (AMH) levels, antral follicle count (AFC), and the number of prior ART cycles, which may influence clinical pregnancy outcomes. After adjusting for these variables, multivariate regression analysis indicated that the timing of endometrial preparation for D6 single blastocyst transfer did not significantly affect clinical pregnancy rates.
Conclusion: In conclusion, our retrospective data suggest that transferring single D6 blastocysts on either the sixth or seventh day of progesterone administration in HRT-FET cycles yields comparable clinical pregnancy outcomes. Until further prospective evidence emerges, our findings do not support routine delay of D6 blastocyst transfers in HRT cycles.
Keywords: day-6 blastocyst, HRT-FET, transfer timing, clinical pregnancy rate