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已发表论文
经皮穴位电刺激通过调节肠道菌群改善老年患者泌尿外科腹腔镜术后睡眠障碍的前瞻性对照试验研究方案
Authors Liu X , Fan Y, Wu C , Hu R, Wang T, Cao Y, Liu G, Zhang L , Han T
Received 17 November 2024
Accepted for publication 13 September 2025
Published 29 September 2025 Volume 2025:17 Pages 2387—2398
DOI https://doi.org/10.2147/NSS.S503267
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Ahmed BaHammam
Xuming Liu,1 Yichang Fan,1 Chen Wu,1 Ran Hu,2 Tengti Wang,1 Yang Cao,1 Guokai Liu,2 Li Zhang,3 Tiandong Han4
1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Department of Anesthesiology and Operating Room, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 4Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China
Correspondence: Tiandong Han, Email cruiser412@163.com Li Zhang, Email zhangli8828@163.com
Background: Postoperative sleep disorders (PSD) are common complications that may impair recovery and increase the risk of adverse events after surgery. Transcutaneous electrical acupoint stimulation (TEAS), a non-invasive therapy based on traditional Chinese medicine, has shown potential in improving sleep quality. This study aims to investigate whether TEAS can alleviate PSD in older patients undergoing urologic laparoscopic surgery.
Methods: This is a prospective, randomized, double-blind, controlled clinical trial. A total of 124 patients scheduled for urologic laparoscopic surgery will be randomly assigned to either the TEAS group (receiving active stimulation) or the sham group (receiving placebo stimulation). Randomization will also be stratified according to the use of dexmedetomidine. The primary outcome is the Athens Insomnia Scale (AIS) score on the postoperative night (D2), compared between groups using ANCOVA adjusted for preoperative (baseline) AIS and the dexmedetomidine stratification factor. Secondary outcomes include the night-to-night trajectory of AIS across D0–D2, objective sleep parameters measured by a portable monitor on D0–D2, postoperative VAS pain scores, perioperative changes in intestinal microbiota and serum brain–gut peptides, intraoperative hemodynamics and drug consumption, durations of surgery/anesthesia/extubation, postoperative complications, and healthcare-related costs.
Discussion: This trial aims to explore whether TEAS can improve postoperative sleep quality in older patients by regulating intestinal microbiota. The findings are expected to provide evidence supporting the clinical application of TEAS for managing PSD in this patient population.
Clinical Trial Registration: ChiCTR2400086911 (Registered on 15 July 2024) https://www.chictr.org.cn/showproj.html?proj=220900.
Keywords: transcutaneous electrical acupoint stimulation, postoperative sleep disorders, intestinal microbiota, urologic surgery
1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Department of Anesthesiology and Operating Room, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 4Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China
Correspondence: Tiandong Han, Email cruiser412@163.com Li Zhang, Email zhangli8828@163.com
Background: Postoperative sleep disorders (PSD) are common complications that may impair recovery and increase the risk of adverse events after surgery. Transcutaneous electrical acupoint stimulation (TEAS), a non-invasive therapy based on traditional Chinese medicine, has shown potential in improving sleep quality. This study aims to investigate whether TEAS can alleviate PSD in older patients undergoing urologic laparoscopic surgery.
Methods: This is a prospective, randomized, double-blind, controlled clinical trial. A total of 124 patients scheduled for urologic laparoscopic surgery will be randomly assigned to either the TEAS group (receiving active stimulation) or the sham group (receiving placebo stimulation). Randomization will also be stratified according to the use of dexmedetomidine. The primary outcome is the Athens Insomnia Scale (AIS) score on the postoperative night (D2), compared between groups using ANCOVA adjusted for preoperative (baseline) AIS and the dexmedetomidine stratification factor. Secondary outcomes include the night-to-night trajectory of AIS across D0–D2, objective sleep parameters measured by a portable monitor on D0–D2, postoperative VAS pain scores, perioperative changes in intestinal microbiota and serum brain–gut peptides, intraoperative hemodynamics and drug consumption, durations of surgery/anesthesia/extubation, postoperative complications, and healthcare-related costs.
Discussion: This trial aims to explore whether TEAS can improve postoperative sleep quality in older patients by regulating intestinal microbiota. The findings are expected to provide evidence supporting the clinical application of TEAS for managing PSD in this patient population.
Clinical Trial Registration: ChiCTR2400086911 (Registered on 15 July 2024) https://www.chictr.org.cn/showproj.html?proj=220900.
Keywords: transcutaneous electrical acupoint stimulation, postoperative sleep disorders, intestinal microbiota, urologic surgery