108139
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
溶瘤病毒疗法治疗胶质瘤：多学科临床与研究策略的文献计量学路线图
Received 30 July 2025
Accepted for publication 20 September 2025
Published 26 September 2025 Volume 2025:18 Pages 6167—6185
DOI https://doi.org/10.2147/JMDH.S557248
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Charles V Pollack
Shichao Liu, Risheng Liang
Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, People’s Republic of China
Correspondence: Risheng Liang, Email doctorlr@163.com Shichao Liu, Email lsc@fjmu.edu.cn
Background: Glioblastoma (GBM) remains the most lethal primary brain tumor with a dismal prognosis despite standard therapies. Oncolytic viruses (OVs), which selectively destroy cancer cells and stimulate anti-tumor immunity, have emerged as a promising therapeutic strategy. This study aims to systematically map the global research landscape, knowledge structure, and evolutionary trends of OV therapy for gliomas.
Methods: Publications from 2009 to 2025 were retrieved from the Web of Science Core Collection (WOSCC). Bibliometric analysis and knowledge mapping were conducted using CiteSpace and RStudio to analyze collaboration networks, co-citation patterns, and keyword evolution.
Results: A total of 559 publications were analyzed. The annual output has grown exponentially since 2020, with the USA and China being the most productive countries. A clear paradigm shift was identified, moving from early research focused on direct oncolysis by viral vectors like Herpes Simplex Virus to a current emphasis on immuno-virotherapy. Recent hotspots are dominated by keywords such as immunotherapy, combination, tumor microenvironment, and T-cells, indicating a research trajectory towards complex, synergistic treatment strategies. Harvard University and Brigham and Women’s Hospital are the leading institutions in this field.
Conclusion: The research field of oncolytic virotherapy for gliomas is rapidly advancing, with a clear evolution towards sophisticated combination immunotherapies. This analysis provides a comprehensive roadmap of the field’s knowledge base and identifies key future directions, including overcoming delivery barriers and developing personalized treatment protocols, to accelerate the clinical translation of this promising therapy.
Keywords: oncolytic viruses, gliomas, bibliometrics, research trends, CiteSpace
Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, People’s Republic of China
Correspondence: Risheng Liang, Email doctorlr@163.com Shichao Liu, Email lsc@fjmu.edu.cn
Background: Glioblastoma (GBM) remains the most lethal primary brain tumor with a dismal prognosis despite standard therapies. Oncolytic viruses (OVs), which selectively destroy cancer cells and stimulate anti-tumor immunity, have emerged as a promising therapeutic strategy. This study aims to systematically map the global research landscape, knowledge structure, and evolutionary trends of OV therapy for gliomas.
Methods: Publications from 2009 to 2025 were retrieved from the Web of Science Core Collection (WOSCC). Bibliometric analysis and knowledge mapping were conducted using CiteSpace and RStudio to analyze collaboration networks, co-citation patterns, and keyword evolution.
Results: A total of 559 publications were analyzed. The annual output has grown exponentially since 2020, with the USA and China being the most productive countries. A clear paradigm shift was identified, moving from early research focused on direct oncolysis by viral vectors like Herpes Simplex Virus to a current emphasis on immuno-virotherapy. Recent hotspots are dominated by keywords such as immunotherapy, combination, tumor microenvironment, and T-cells, indicating a research trajectory towards complex, synergistic treatment strategies. Harvard University and Brigham and Women’s Hospital are the leading institutions in this field.
Conclusion: The research field of oncolytic virotherapy for gliomas is rapidly advancing, with a clear evolution towards sophisticated combination immunotherapies. This analysis provides a comprehensive roadmap of the field’s knowledge base and identifies key future directions, including overcoming delivery barriers and developing personalized treatment protocols, to accelerate the clinical translation of this promising therapy.
Keywords: oncolytic viruses, gliomas, bibliometrics, research trends, CiteSpace