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已发表论文
马瑞辛 1 通过调节炎症与铁死亡之间的相互作用缓解癫痫症状
Authors Liu Y , Xu S, Luo Y , Xiao X, Jiang X, Xiao W, Xie R, Deng X, Li Z, Cao Y , Chang Y, Wu D, Xu H, Zhao W
Received 15 May 2025
Accepted for publication 26 September 2025
Published 9 October 2025 Volume 2025:18 Pages 14039—14057
DOI https://doi.org/10.2147/JIR.S540483
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Dharmappa Krishnappa
Yueying Liu,1,* Shengjie Xu,1,* Yufan Luo,1,* Xue Xiao,1 Xiaofan Jiang,1 Wei Xiao,1 Ruijin Xie,1 Xianhui Deng,2 Zhen Li,3 Yingsi Cao,1 Yuanjin Chang,1 Dongqin Wu,1 Hua Xu,1 Wenjing Zhao4
1Department of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Department of Neonatology, Jiangyin People’s Hospital of Nantong University, Wuxi, People’s Republic of China; 3Department of Child Health and Development, Center for Disease Control and Prevention of Yangzhou, Yangzhou, People’s Republic of China; 4Department of Anesthesiology, Yangzhou Key Laboratory of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenjing Zhao, Department of Anesthesiology, Yangzhou Key Laboratory of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, People’s Republic of China, Email zhaowenjingmo@163.com
Background: Epilepsy is among the most common neurological disorders in children. The persistent challenges of drug-resistant epilepsy and the adverse effects associated with antiepileptic drugs highlight the need for innovative therapeutic approaches for pediatric epilepsy. Both ferroptosis and neuroinflammation have been identified as key mechanisms in the development of epilepsy. Recent studies suggest that Maresin1 may hold therapeutic promise for neurological diseases. However, the neuroprotective effects of Maresin1, particularly through the ferroptosis pathway in the context of seizures, remain insufficiently explored.
Objective: This study aimed to investigate the protective effects of MaR1 against seizures, with a focus on its regulatory role in neuroinflammation and neuronal ferroptosis.
Methods: Seizure severity was evaluated using the modified Racine scale. Cognitive abilities were assessed via the Morris Water Maze and Novel Object Recognition tests. Magnetic Resonance Imaging was used to determine hippocampal iron accumulation. Nissl staining quantified neuronal density, while Transmission Electron Microscopy examined mitochondrial ultrastructure. Western blotting was performed to analyze protein expression changes across experimental groups.
Results: Pretreatment with MaR1 or a ferroptosis inhibitor significantly reduced seizure severity and improved cognitive performance in epileptic mice.
Conclusion: These findings demonstrate that MaR1 can attenuate both seizure severity and cognitive impairment in epilepsy models, potentially through modulation of neuroinflammation and the ferroptosis pathway.
Keywords: epilepsy, Maresin1, neuroinflammation, ferroptosis
1Department of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Department of Neonatology, Jiangyin People’s Hospital of Nantong University, Wuxi, People’s Republic of China; 3Department of Child Health and Development, Center for Disease Control and Prevention of Yangzhou, Yangzhou, People’s Republic of China; 4Department of Anesthesiology, Yangzhou Key Laboratory of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenjing Zhao, Department of Anesthesiology, Yangzhou Key Laboratory of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, People’s Republic of China, Email zhaowenjingmo@163.com
Background: Epilepsy is among the most common neurological disorders in children. The persistent challenges of drug-resistant epilepsy and the adverse effects associated with antiepileptic drugs highlight the need for innovative therapeutic approaches for pediatric epilepsy. Both ferroptosis and neuroinflammation have been identified as key mechanisms in the development of epilepsy. Recent studies suggest that Maresin1 may hold therapeutic promise for neurological diseases. However, the neuroprotective effects of Maresin1, particularly through the ferroptosis pathway in the context of seizures, remain insufficiently explored.
Objective: This study aimed to investigate the protective effects of MaR1 against seizures, with a focus on its regulatory role in neuroinflammation and neuronal ferroptosis.
Methods: Seizure severity was evaluated using the modified Racine scale. Cognitive abilities were assessed via the Morris Water Maze and Novel Object Recognition tests. Magnetic Resonance Imaging was used to determine hippocampal iron accumulation. Nissl staining quantified neuronal density, while Transmission Electron Microscopy examined mitochondrial ultrastructure. Western blotting was performed to analyze protein expression changes across experimental groups.
Results: Pretreatment with MaR1 or a ferroptosis inhibitor significantly reduced seizure severity and improved cognitive performance in epileptic mice.
Conclusion: These findings demonstrate that MaR1 can attenuate both seizure severity and cognitive impairment in epilepsy models, potentially through modulation of neuroinflammation and the ferroptosis pathway.
Keywords: epilepsy, Maresin1, neuroinflammation, ferroptosis