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已发表论文
语义性痴呆的临床表现及其神经基础：来自脑成像研究的趋同证据
Authors Chen X, Chen Y, Peng G, Liu X
Received 9 April 2025
Accepted for publication 3 September 2025
Published 9 October 2025 Volume 2025:20 Pages 1715—1728
DOI https://doi.org/10.2147/CIA.S520351
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Zhi-Ying Wu
Xuanyu Chen, Yi Chen, Guoping Peng, Xiaoyan Liu
Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
Correspondence: Guoping Peng, Email guopingpeng@zju.edu.cn Xiaoyan Liu, Email yy6sweet@zju.edu.cn
Abstract: Semantic dementia (SD) is a progressive neurodegenerative disorder primarily characterized by core linguistic deficits, notably impaired confrontation naming and single-word comprehension. Associated features include surface dyslexia, prosopagnosia, relatively preserved speech production, and emotional or behavioral abnormalities. Neuroimaging reveals initial asymmetrical atrophy of the anterior temporal pole, with subsequent progression posteriorly and contralaterally. Early detection is challenging due to initial presentation often manifesting as mild word-finding difficulties, furthermore, comorbid behavioral-emotional symptoms and distinct clinical profiles associated with right- versus left-sided atrophy complicate diagnosis. Therefore, this paper comprehensively delineates the principal clinical features of SD, encompassing language deficits, emotional impairment, behavioral disturbances, and other domains. It also reviews structural and functional imaging findings and investigates the relationship between clinical manifestations and patterns of brain injury. To advance understanding of SD’s clinical manifestation, the paper introduces the controlled semantic and social-semantic frameworks.
Keywords: semantic dementia, primary progressive aphasia, clinical manifestation, neuroimaging
Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
Correspondence: Guoping Peng, Email guopingpeng@zju.edu.cn Xiaoyan Liu, Email yy6sweet@zju.edu.cn
Abstract: Semantic dementia (SD) is a progressive neurodegenerative disorder primarily characterized by core linguistic deficits, notably impaired confrontation naming and single-word comprehension. Associated features include surface dyslexia, prosopagnosia, relatively preserved speech production, and emotional or behavioral abnormalities. Neuroimaging reveals initial asymmetrical atrophy of the anterior temporal pole, with subsequent progression posteriorly and contralaterally. Early detection is challenging due to initial presentation often manifesting as mild word-finding difficulties, furthermore, comorbid behavioral-emotional symptoms and distinct clinical profiles associated with right- versus left-sided atrophy complicate diagnosis. Therefore, this paper comprehensively delineates the principal clinical features of SD, encompassing language deficits, emotional impairment, behavioral disturbances, and other domains. It also reviews structural and functional imaging findings and investigates the relationship between clinical manifestations and patterns of brain injury. To advance understanding of SD’s clinical manifestation, the paper introduces the controlled semantic and social-semantic frameworks.
Keywords: semantic dementia, primary progressive aphasia, clinical manifestation, neuroimaging