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已发表论文
剪切波弹性成像定量评估下肢慢性静脉疾病患者皮肤弹性早期变化
Authors Lv D, Yang X, Mao X, Zhang M, Ma X, Liu Y, Li G , Yang B
Received 2 September 2025
Accepted for publication 1 October 2025
Published 9 October 2025 Volume 2025:18 Pages 6095—6105
DOI https://doi.org/10.2147/IJGM.S564514
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Redoy Ranjan
Dan Lv,1,* Xi Yang,1,* Xin Mao,1,* Mei Zhang,1,* Xuemeihui Ma,1 Yuanyuan Liu,1 Guangsen Li,1 Bingbing Yang2
1Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116027, People’s Republic of China; 2Department of Cardiovascular Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116027, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Bingbing Yang, Email yangbingbing0124@sina.com Guangsen Li, Email liguangsen009@163.com
Objective: To explore the value of shear wave elastography (SWE) in quantitatively evaluating skin elasticity during early changes in patients with chronic venous disease (CVD) of the lower extremity.
Methods: This retrospective study analyzed 112 patients with CVD of the lower extremity, who were enrolled and divided into four groups according to the Clinical-Etiology-Anatomy-Pathophysiology (CEAP) classification criteria, including group C2 (n=33), group C3 (n=35), group C4a (n=24), and group C4b (n=20). Additionally, 30 healthy individuals were recruited as the control group. Differences in baseline clinical characteristics, laboratory parameters, conventional ultrasound parameters and SWE parameters among the five groups were compared. Correlations between SWE parameters of the dermal and subcutaneous tissue layers and laboratory parameters were analyzed.
Results: Compared with the control and C2 groups, the C3, C4a, and C4b groups exhibited significantly higher levels of C-reactive protein (CRP), matrix metalloproteinase-2 (MMP-2), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), subcutaneous tissue thickness (SCTT), maximum Young’s modulus of subcutaneous tissue (SCT-Emax), mean Young’s modulus of subcutaneous tissue (SCT-Emean), and minimum Young’s modulus of subcutaneous tissue (SCT-Emin) (all P< 0.05). Furthermore, these indices progressively increased from group C3, group C4a to group C4b (all P< 0.05). Compared to the control, C2, and C3 groups, both the C4a and C4b groups demonstrated greater dermal thickness (DT), maximum Young’s modulus of dermal layer (D-Emax), mean Young’s modulus of dermal layer (D-Emean), and minimum Young’s modulus of dermal layer (D-Emin) (all P< 0.05), with group C4b showing higher values than group C4a (all P< 0.05). Correlation analysis revealed that SWE parameters of the dermal and subcutaneous tissue layers were significantly correlated with MMP-2 and IL-6, respectively.
Conclusion: SWE enables quantitative assessment of skin elasticity during the early changes in patients with CVD of the lower extremity.
Keywords: shear wave elastography, skin elasticity, chronic venous disease
1Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116027, People’s Republic of China; 2Department of Cardiovascular Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116027, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Bingbing Yang, Email yangbingbing0124@sina.com Guangsen Li, Email liguangsen009@163.com
Objective: To explore the value of shear wave elastography (SWE) in quantitatively evaluating skin elasticity during early changes in patients with chronic venous disease (CVD) of the lower extremity.
Methods: This retrospective study analyzed 112 patients with CVD of the lower extremity, who were enrolled and divided into four groups according to the Clinical-Etiology-Anatomy-Pathophysiology (CEAP) classification criteria, including group C2 (n=33), group C3 (n=35), group C4a (n=24), and group C4b (n=20). Additionally, 30 healthy individuals were recruited as the control group. Differences in baseline clinical characteristics, laboratory parameters, conventional ultrasound parameters and SWE parameters among the five groups were compared. Correlations between SWE parameters of the dermal and subcutaneous tissue layers and laboratory parameters were analyzed.
Results: Compared with the control and C2 groups, the C3, C4a, and C4b groups exhibited significantly higher levels of C-reactive protein (CRP), matrix metalloproteinase-2 (MMP-2), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), subcutaneous tissue thickness (SCTT), maximum Young’s modulus of subcutaneous tissue (SCT-Emax), mean Young’s modulus of subcutaneous tissue (SCT-Emean), and minimum Young’s modulus of subcutaneous tissue (SCT-Emin) (all P< 0.05). Furthermore, these indices progressively increased from group C3, group C4a to group C4b (all P< 0.05). Compared to the control, C2, and C3 groups, both the C4a and C4b groups demonstrated greater dermal thickness (DT), maximum Young’s modulus of dermal layer (D-Emax), mean Young’s modulus of dermal layer (D-Emean), and minimum Young’s modulus of dermal layer (D-Emin) (all P< 0.05), with group C4b showing higher values than group C4a (all P< 0.05). Correlation analysis revealed that SWE parameters of the dermal and subcutaneous tissue layers were significantly correlated with MMP-2 and IL-6, respectively.
Conclusion: SWE enables quantitative assessment of skin elasticity during the early changes in patients with CVD of the lower extremity.
Keywords: shear wave elastography, skin elasticity, chronic venous disease