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已发表论文
针刺治疗偏头痛的临床疗效及血浆代谢组学分析
Authors Gao L , Chen Y, Xie C, Zhang Z , Yan Q, Fu QX , Sun M, Zhao L
Received 13 June 2025
Accepted for publication 18 September 2025
Published 9 October 2025 Volume 2025:18 Pages 5283—5301
DOI https://doi.org/10.2147/JPR.S546838
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Houman Danesh
Lei Gao,1,* Ying Chen,1,* Chaorong Xie,1 ZhiYang Zhang,1 Qinyi Yan,1 Qi Xuan Fu,1 Mingsheng Sun,1 Ling Zhao1– 3
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu, Sichuan, People’s Republic of China; 3Acupuncture & Chronobiology Key Laboratory of Sichuan Province, Chengdu, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ling Zhao, Email zhaoling@cdutcm.edu.cn
Purpose: Migraine, a prevalent neurological disorder characterized by recurrent, debilitating headaches, poses significant challenges due to limited understanding of its pathophysiology and variable treatment outcomes. Acupuncture has emerged as a promising intervention, yet its clinical efficacy and underlying metabolic mechanisms remain underexplored. This study aimed to evaluate the therapeutic effects of true acupuncture (TA) compared to sham acupuncture (SA) in migraine patients and to elucidate associated metabolic changes using non-targeted plasma metabolomics.
Patients and Methods: Fifty-two migraine patients were randomized into TA and SA groups, receiving 12 sessions of acupuncture over four weeks, with clinical assessments and plasma sample collection at baseline and week 4.
Results: The TA group exhibited a significant reduction in migraine attack frequency (p< 0.05) compared to baseline, while the SA group showed no significant change (p> 0.05). Additionally, the TA group demonstrated greater improvements in attack frequency, duration, visual analog scale (VAS) scores, and migraine-specific quality of life (MSQ) emotional and dysfunction subscales compared to the SA group (p< 0.05). Metabolomic analysis identified distinct metabolic profiles. TA was associated with five key metabolites, including the lipid regulators 1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE) and Pe (16:0/19,20-epdpe), which correlated with reduced attack duration and improved quality of life scores. In contrast, metabolic changes in the SA group were less pronounced. Pathway analysis revealed that TA predominantly modulated amino acid and pyrimidine metabolism.
Conclusion: These findings indicate that TA is more effective than SA in alleviating migraine symptoms, likely through specific regulation of metabolic pathways. The identified metabolites offer potential biomarkers for evaluating treatment response, though further validation is required.
Keywords: migraine, acupuncture, metabolomics, lipid metabolism, amino acid metabolism
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu, Sichuan, People’s Republic of China; 3Acupuncture & Chronobiology Key Laboratory of Sichuan Province, Chengdu, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ling Zhao, Email zhaoling@cdutcm.edu.cn
Purpose: Migraine, a prevalent neurological disorder characterized by recurrent, debilitating headaches, poses significant challenges due to limited understanding of its pathophysiology and variable treatment outcomes. Acupuncture has emerged as a promising intervention, yet its clinical efficacy and underlying metabolic mechanisms remain underexplored. This study aimed to evaluate the therapeutic effects of true acupuncture (TA) compared to sham acupuncture (SA) in migraine patients and to elucidate associated metabolic changes using non-targeted plasma metabolomics.
Patients and Methods: Fifty-two migraine patients were randomized into TA and SA groups, receiving 12 sessions of acupuncture over four weeks, with clinical assessments and plasma sample collection at baseline and week 4.
Results: The TA group exhibited a significant reduction in migraine attack frequency (p< 0.05) compared to baseline, while the SA group showed no significant change (p> 0.05). Additionally, the TA group demonstrated greater improvements in attack frequency, duration, visual analog scale (VAS) scores, and migraine-specific quality of life (MSQ) emotional and dysfunction subscales compared to the SA group (p< 0.05). Metabolomic analysis identified distinct metabolic profiles. TA was associated with five key metabolites, including the lipid regulators 1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE) and Pe (16:0/19,20-epdpe), which correlated with reduced attack duration and improved quality of life scores. In contrast, metabolic changes in the SA group were less pronounced. Pathway analysis revealed that TA predominantly modulated amino acid and pyrimidine metabolism.
Conclusion: These findings indicate that TA is more effective than SA in alleviating migraine symptoms, likely through specific regulation of metabolic pathways. The identified metabolites offer potential biomarkers for evaluating treatment response, though further validation is required.
Keywords: migraine, acupuncture, metabolomics, lipid metabolism, amino acid metabolism