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已发表论文
超越表皮：探究特应性皮炎发病机制中的肠-皮肤轴及代谢途径
Received 27 June 2025
Accepted for publication 1 October 2025
Published 8 October 2025 Volume 2025:18 Pages 6123—6136
DOI https://doi.org/10.2147/IJGM.S550152
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Glenn Cruse
Lin Yang, Ji-Ning Xia
Department of Dermatology, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jiaxing, Zhejiang Province, People’s Republic of China
Correspondence: Ji-Ning Xia, Department of Dermatology, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, No. 1501 of Zhongshan East Road, Nanhu District, Jiaxing, Zhejiang Province, People’s Republic of China, Tel +86 13736859611, Email dermatoxia@163.com
Abstract: Atopic dermatitis (AD), is a chronic, recurrent inflammatory skin condition characterized by eczema-like lesions, itching, and dryness. It often coexists with other atopic comorbidities, including food allergies (FA), allergic rhinitis (AR), and allergic asthma (AA). The pathogenesis of AD is complex and multifactorial, involving immune dysregulation, epidermal barrier disruption, and dysbiosis of intestinal and skin microbiota. Recent research has increasingly focused on the gut-skin axis, highlighting the role of intestinal microbiota and their metabolic products in regulating skin immunity and barrier function. Dietary changes and metabolic pathway modulation are emerging as promising therapeutic strategies. This article reviews recent advancements in AD research across three dimensions: gut microbiota, metabolomics, and comorbidities, while exploring potential therapeutic approaches to regulate gut microbiota and target metabolic pathways.
Keywords: dermatitis, atopy, gut microbiota, metabolomics, comorbidity
Department of Dermatology, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Jiaxing, Zhejiang Province, People’s Republic of China
Correspondence: Ji-Ning Xia, Department of Dermatology, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, No. 1501 of Zhongshan East Road, Nanhu District, Jiaxing, Zhejiang Province, People’s Republic of China, Tel +86 13736859611, Email dermatoxia@163.com
Abstract: Atopic dermatitis (AD), is a chronic, recurrent inflammatory skin condition characterized by eczema-like lesions, itching, and dryness. It often coexists with other atopic comorbidities, including food allergies (FA), allergic rhinitis (AR), and allergic asthma (AA). The pathogenesis of AD is complex and multifactorial, involving immune dysregulation, epidermal barrier disruption, and dysbiosis of intestinal and skin microbiota. Recent research has increasingly focused on the gut-skin axis, highlighting the role of intestinal microbiota and their metabolic products in regulating skin immunity and barrier function. Dietary changes and metabolic pathway modulation are emerging as promising therapeutic strategies. This article reviews recent advancements in AD research across three dimensions: gut microbiota, metabolomics, and comorbidities, while exploring potential therapeutic approaches to regulate gut microbiota and target metabolic pathways.
Keywords: dermatitis, atopy, gut microbiota, metabolomics, comorbidity