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已发表论文
术前白细胞与白蛋白比值与心脏瓣膜手术短期和长期结局的相关性：一项回顾性队列研究
Authors Lin Y, Liao X, Li S, Yan X, Chen L, Lin Y
Received 22 June 2025
Accepted for publication 30 September 2025
Published 8 October 2025 Volume 2025:18 Pages 13985—13997
DOI https://doi.org/10.2147/JIR.S548782
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Qing Lin
Yanhong Lin,1,2,* Xiaoqin Liao,1,2,* Sailan Li,1 Xin Yan,1 Liangwan Chen,3,4 Yanjuan Lin1,2
1Department of Cardiac Surgery Nursing, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Department of Cardiac Surgery, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 4Fujian Provincial Special Reserve Talents Laboratory, Fuzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Liangwan Chen, Email fjxhlwc@163.com Yanjuan Lin, Email fjxhyjl@163.com
Background: The leukocyte-to-albumin ratio (LAR) serves as an integrated marker of both inflammation and nutritional status. However, there is currently a lack of research on the correlation between LAR and the prognosis of valvular heart disease (VHD) surgery patients. This study investigates the prognostic significance of LAR in patients undergoing VHD surgery.
Methods: This is a single-center, retrospective cohort study. From May 2021 to July 2024, we retrospectively analyzed the clinical data of 773 patients who underwent VHD surgery. Patients were categorized into low- and high-LAR groups using a threshold value of 0.2. Multivariable logistic regression models were used to assess the association between the LAR and adverse outcomes.
Results: This study included a total of 773 patients, with 615 in the low LAR group and 158 in the high LAR group. The main findings included that LAR ≥ 0.2 was an independent protective factor for severe arrhythmias(SA)(OR:0.231, 95% CI:0.103– 0.518, p=0.000), but was also significantly associated with increased risk of acute kidney injury(AKI), prolonged mechanical ventilation(MV) time and prolonged length of stays(LOS)(p < 0.05). Multifactorial analysis further confirmed that LAR was independently and positively associated with LOS (B=16.453, t=3.090, p=0.002).
Conclusion: In summary, an elevated LAR (≥ 0.2) exhibits a paradoxical role, serving as an independent predictor for reduced SA while concurrently correlating with an extended LOS, thereby establishing its dual nature as a perioperative risk biomarker.
Keywords: valvular heart disease, leukocyte to albumin ratio, severe arrhythmias, length of stays, poor prognosis
1Department of Cardiac Surgery Nursing, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Department of Cardiac Surgery, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 4Fujian Provincial Special Reserve Talents Laboratory, Fuzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Liangwan Chen, Email fjxhlwc@163.com Yanjuan Lin, Email fjxhyjl@163.com
Background: The leukocyte-to-albumin ratio (LAR) serves as an integrated marker of both inflammation and nutritional status. However, there is currently a lack of research on the correlation between LAR and the prognosis of valvular heart disease (VHD) surgery patients. This study investigates the prognostic significance of LAR in patients undergoing VHD surgery.
Methods: This is a single-center, retrospective cohort study. From May 2021 to July 2024, we retrospectively analyzed the clinical data of 773 patients who underwent VHD surgery. Patients were categorized into low- and high-LAR groups using a threshold value of 0.2. Multivariable logistic regression models were used to assess the association between the LAR and adverse outcomes.
Results: This study included a total of 773 patients, with 615 in the low LAR group and 158 in the high LAR group. The main findings included that LAR ≥ 0.2 was an independent protective factor for severe arrhythmias(SA)(OR:0.231, 95% CI:0.103– 0.518, p=0.000), but was also significantly associated with increased risk of acute kidney injury(AKI), prolonged mechanical ventilation(MV) time and prolonged length of stays(LOS)(p < 0.05). Multifactorial analysis further confirmed that LAR was independently and positively associated with LOS (B=16.453, t=3.090, p=0.002).
Conclusion: In summary, an elevated LAR (≥ 0.2) exhibits a paradoxical role, serving as an independent predictor for reduced SA while concurrently correlating with an extended LOS, thereby establishing its dual nature as a perioperative risk biomarker.
Keywords: valvular heart disease, leukocyte to albumin ratio, severe arrhythmias, length of stays, poor prognosis