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已发表论文
超越激素替代疗法：植物雌激素对绝经后女性运动机能和生理适应的多方面影响优化作用
Authors Hu Y, Hu Y, Li T, Shi R
Received 29 May 2025
Accepted for publication 9 September 2025
Published 8 October 2025 Volume 2025:20 Pages 1695—1711
DOI https://doi.org/10.2147/CIA.S539923
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Maddalena Illario
Yingjia Hu, Yi Hu, Tao Li, Rengfei Shi
School of Health and Exercise, Shanghai University of Sport, Shanghai, People’s Republic of China
Correspondence: Rengfei Shi, School of Health and Exercise, Shanghai University of Sport, Shanghai, People’s Republic of China, Tel +86 13661498054, Email rfshi@sus.edu.cn
Abstract: Phytoestrogens (PEs), a class of naturally occurring plant compounds primarily categorized into isoflavones, lignans, flavonoids, coumarins, and stilbenes, exhibit structural similarity to endogenous estrogens and exert regulatory effects through estrogen receptors. This comprehensive review examines the multifaceted roles of PEs in enhancing exercise performance and promoting health among postmenopausal women. Current evidence demonstrates that PEs not only ameliorate characteristic menopausal symptoms but, more significantly, improve physical function through multiple mechanisms: (1) augmenting muscle protein synthesis while mitigating inflammation and oxidative stress to optimize muscular performance; (2) modulating glucolipid metabolism and cardiovascular function to establish physiological foundations for exercise; and (3) preserving bone mineral density and regulating neurotransmitter activity to maintain motor coordination. Although combined PE-exercise interventions demonstrate synergistic benefits, their efficacy is influenced by dosage variations and interindividual metabolic differences. Future investigations should prioritize the development of precision PE applications to optimize kinesiological outcomes and health parameters in postmenopausal populations.
Keywords: phytoestrogens, elderly, exercise performance, physical activity, menopausal symptoms
School of Health and Exercise, Shanghai University of Sport, Shanghai, People’s Republic of China
Correspondence: Rengfei Shi, School of Health and Exercise, Shanghai University of Sport, Shanghai, People’s Republic of China, Tel +86 13661498054, Email rfshi@sus.edu.cn
Abstract: Phytoestrogens (PEs), a class of naturally occurring plant compounds primarily categorized into isoflavones, lignans, flavonoids, coumarins, and stilbenes, exhibit structural similarity to endogenous estrogens and exert regulatory effects through estrogen receptors. This comprehensive review examines the multifaceted roles of PEs in enhancing exercise performance and promoting health among postmenopausal women. Current evidence demonstrates that PEs not only ameliorate characteristic menopausal symptoms but, more significantly, improve physical function through multiple mechanisms: (1) augmenting muscle protein synthesis while mitigating inflammation and oxidative stress to optimize muscular performance; (2) modulating glucolipid metabolism and cardiovascular function to establish physiological foundations for exercise; and (3) preserving bone mineral density and regulating neurotransmitter activity to maintain motor coordination. Although combined PE-exercise interventions demonstrate synergistic benefits, their efficacy is influenced by dosage variations and interindividual metabolic differences. Future investigations should prioritize the development of precision PE applications to optimize kinesiological outcomes and health parameters in postmenopausal populations.
Keywords: phytoestrogens, elderly, exercise performance, physical activity, menopausal symptoms