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已发表论文
纳米技术在妇科癌症诊断和治疗中的进展
Authors Zhao R, Liu Z, Fan L, Fu M, Wu Y
Received 25 May 2025
Accepted for publication 14 September 2025
Published 8 October 2025 Volume 2025:20 Pages 12263—12281
DOI https://doi.org/10.2147/IJN.S535644
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Eng San Thian
Ruimin Zhao,1 Zongyu Liu,2 Limei Fan,1 Miaomiao Fu,1 Yishi Wu1
1Department of Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People’s Republic of China; 2Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People’s Republic of China
Correspondence: Yishi Wu, Email wys610428@jlu.edu.cn
Abstract: Nanotechnology platforms facilitate therapeutic drug delivery and offer various advantages over conventional drugs, such as biocompatibility, non-inflammatory effects, high therapeutic output, biodegradability, non-toxicity, and biocompatibility. Due to the inherent drawbacks of conventional drug delivery to cancerous tissues, nanotechnology-based alternatives have been developed for such diseases. Gynecologic malignant tumors (GCs), include various types of cervical, endometrial, and ovarian cancers. The epidemiological characteristics of the tumors show that their incidence is increasing significantly and tends to be younger, which is a serious threat to women’s physical and mental health. This article provides a systematic review of the latest research results on nanomaterials in the diagnosis and treatment of gynecological malignancies, including 2 sections on nanomaterials-based diagnostic and therapeutic strategies in gynecological cancers. In particular, the article also analyzes the challenges faced by nanotechnology, including toxicity, technology, and clinical translation issues. These applications not only improve the therapeutic efficacy of gynecological cancers, but also reduce the toxicity and side effects, and provide a new direction for the precise treatment of gynecological cancers.
Keywords: gynecologic cancer, nanomaterials, diagnosis, treatment, emerging tools
1Department of Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People’s Republic of China; 2Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People’s Republic of China
Correspondence: Yishi Wu, Email wys610428@jlu.edu.cn
Abstract: Nanotechnology platforms facilitate therapeutic drug delivery and offer various advantages over conventional drugs, such as biocompatibility, non-inflammatory effects, high therapeutic output, biodegradability, non-toxicity, and biocompatibility. Due to the inherent drawbacks of conventional drug delivery to cancerous tissues, nanotechnology-based alternatives have been developed for such diseases. Gynecologic malignant tumors (GCs), include various types of cervical, endometrial, and ovarian cancers. The epidemiological characteristics of the tumors show that their incidence is increasing significantly and tends to be younger, which is a serious threat to women’s physical and mental health. This article provides a systematic review of the latest research results on nanomaterials in the diagnosis and treatment of gynecological malignancies, including 2 sections on nanomaterials-based diagnostic and therapeutic strategies in gynecological cancers. In particular, the article also analyzes the challenges faced by nanotechnology, including toxicity, technology, and clinical translation issues. These applications not only improve the therapeutic efficacy of gynecological cancers, but also reduce the toxicity and side effects, and provide a new direction for the precise treatment of gynecological cancers.
Keywords: gynecologic cancer, nanomaterials, diagnosis, treatment, emerging tools