108139
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
一项关于美国肥胖成年人尿液中肠内乳酮与睡眠质量关系的横断面研究
Authors Xu Q , Huang Y, Chen X , Lin C
Received 8 July 2025
Accepted for publication 30 September 2025
Published 7 October 2025 Volume 2025:17 Pages 2529—2540
DOI https://doi.org/10.2147/NSS.S551821
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Ahmed BaHammam
Qiaoli Xu, Yisen Huang, Xinqi Chen, Chanchan Lin
Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, People’s Republic of China
Correspondence: Qiaoli Xu, Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, No. 248-252 East Street, Licheng District, Quanzhou, Fujian, 362000, People’s Republic of China, Email xql202405@163.com
Objective: This study aimed to appraise the association between urinary enterolactone and sleep quality in American obese adults.
Methods: Our study analyzed data from 913 obese adults (2005– 2008) in the National Health and Nutrition Examination Survey (NHANES) database. Enterolactone was tested in urine specimens. The Pittsburgh Sleep Quality Index (PSQI)-like measure reconstructed for NHANES based on prior literature was used to assess sleep quality. Multivariable logistic regression models were used to calculate the associations between urinary enterolactone and sleep quality in American obese adults. We also carried out linear tests utilizing restricted cubic splines to investigate the dose-response relationship between urinary enterolactone and sleep quality. Furthermore, we conducted stratified and interaction analyses to determine whether this relationship remained consistent across various subgroups.
Results: A total of 913 obese participants were included in the analyses. After adjusting for potential confounding factors, each one-unit change in log-transformed urinary enterolactone was associated with 8% lower odds of poor sleep quality (OR=0.92, 95% CI: 0.85– 0.99, p=0.027). When urinary enterolactone was presented in tertiles, this inversely correlation became more significant with increasing levels of urinary enterolactone. Moreover, in stratified analyses, the relationship between urinary enterolactone and sleep quality persisted.
Conclusion: Urinary enterolactone, an indicator of gut microbiome health, is inversely associated with poor sleep quality in American obese adults.
Keywords: enterolactone, sleep duration, sleep quality, obesity, NHANES
Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, People’s Republic of China
Correspondence: Qiaoli Xu, Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, No. 248-252 East Street, Licheng District, Quanzhou, Fujian, 362000, People’s Republic of China, Email xql202405@163.com
Objective: This study aimed to appraise the association between urinary enterolactone and sleep quality in American obese adults.
Methods: Our study analyzed data from 913 obese adults (2005– 2008) in the National Health and Nutrition Examination Survey (NHANES) database. Enterolactone was tested in urine specimens. The Pittsburgh Sleep Quality Index (PSQI)-like measure reconstructed for NHANES based on prior literature was used to assess sleep quality. Multivariable logistic regression models were used to calculate the associations between urinary enterolactone and sleep quality in American obese adults. We also carried out linear tests utilizing restricted cubic splines to investigate the dose-response relationship between urinary enterolactone and sleep quality. Furthermore, we conducted stratified and interaction analyses to determine whether this relationship remained consistent across various subgroups.
Results: A total of 913 obese participants were included in the analyses. After adjusting for potential confounding factors, each one-unit change in log-transformed urinary enterolactone was associated with 8% lower odds of poor sleep quality (OR=0.92, 95% CI: 0.85– 0.99, p=0.027). When urinary enterolactone was presented in tertiles, this inversely correlation became more significant with increasing levels of urinary enterolactone. Moreover, in stratified analyses, the relationship between urinary enterolactone and sleep quality persisted.
Conclusion: Urinary enterolactone, an indicator of gut microbiome health, is inversely associated with poor sleep quality in American obese adults.
Keywords: enterolactone, sleep duration, sleep quality, obesity, NHANES