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已发表论文
新型四环素衍生物齐福霉素对脓肿分枝杆菌的体外活性
Authors Yu Q, Niu X, Hou B, Mao M, Zhu L, Shen W, Wang W
Received 21 May 2025
Accepted for publication 28 September 2025
Published 4 October 2025 Volume 2025:18 Pages 5239—5247
DOI https://doi.org/10.2147/IDR.S538789
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hemant Joshi
Qinlong Yu, Xiaoqin Niu, Bailong Hou, Minjie Mao, Li Zhu, Weifeng Shen, Wei Wang
Department of Clinical Laboratory Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People’s Republic of China
Correspondence: Weifeng Shen, Department of Clinical Laboratory Medicine, The Affiliated Hospital of Jiaxing University, No. 1882, Zhong-Huan South Road, Nanhu District, Jiaxing, Zhejiang, 314000, People’s Republic of China, Tel +86-15968388122, Email jxshwf@zjxu.edu.cn Wei Wang, Department of Clinical Laboratory Medicine, The Affiliated Hospital of Jiaxing University, No. 1882, Zhong-Huan South Road, Nanhu District, Jiaxing, Zhejiang, 314000, People’s Republic of China, Tel +86-13736893655, Email wxp594549048@163.com
Objective: This study aimed to evaluate the in vitro antibacterial activity of zifanocycline against Mycobacterium abscessus.
Methods: From 2019 to 2024, Mycobacterium abscessus isolates from the respiratory tract of patients were collected at a tertiary hospital in Jiaxing City. All isolates were identified for species, subtypes, and the erm 41 gene polymorphism using whole-genome sequencing (WGS). Susceptibility to zifanocycline and 13 comparators was tested using the broth microdilution method, and the combined effects of zifanocycline and seven antibacterial drugs were evaluated.
Results: A total of 67 strains of Mycobacterium abscessus were collected and subjected to whole-genome sequencing. Genomic analysis identified 60 strains of Mycobacterium abscessus subsp. abscessus and 7 strains of Mycobacterium abscessus subsp. massiliense. Among the Mycobacterium abscessus subsp. abscessus strains, 57 exhibited the erm41 T28 genotype, whereas the remaining three showed the erm41 C28 genotype. In our study, zifanocycline (MIC50/MIC90, 0.06/0.25 mg/L) demonstrated a 2-fold lower MIC50 and MIC90 compared to tigecycline (MIC50/MIC90, 0.12/0.5 mg/L), and a 4-fold and 2-fold lower MIC50 and MIC90, respectively, compared to omadacycline (MIC50/MIC90, 0.25/0.5 mg/L). In addition to amikacin and linezolid, zifanocycline demonstrated significantly superior antibacterial activity compared with ciprofloxacin, moxifloxacin, trimethoprim–sulfamethoxazole, cefoxitin, doxycycline, imipenem, and clarithromycin. The combination of zifanocycline and the seven antibacterial drugs used for the treatment of Mycobacterium abscessus showed no significant interactions.
Conclusion: Zifanocycline exhibits positive antibacterial activity against Mycobacterium abscessus in vitro and has potential as an alternative agent in multidrug combination therapy regimens for the treatment of this pathogen.
Keywords: Mycobacterium abscessus, in vitro, tetracycline, zifanocycline
Department of Clinical Laboratory Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People’s Republic of China
Correspondence: Weifeng Shen, Department of Clinical Laboratory Medicine, The Affiliated Hospital of Jiaxing University, No. 1882, Zhong-Huan South Road, Nanhu District, Jiaxing, Zhejiang, 314000, People’s Republic of China, Tel +86-15968388122, Email jxshwf@zjxu.edu.cn Wei Wang, Department of Clinical Laboratory Medicine, The Affiliated Hospital of Jiaxing University, No. 1882, Zhong-Huan South Road, Nanhu District, Jiaxing, Zhejiang, 314000, People’s Republic of China, Tel +86-13736893655, Email wxp594549048@163.com
Objective: This study aimed to evaluate the in vitro antibacterial activity of zifanocycline against Mycobacterium abscessus.
Methods: From 2019 to 2024, Mycobacterium abscessus isolates from the respiratory tract of patients were collected at a tertiary hospital in Jiaxing City. All isolates were identified for species, subtypes, and the erm 41 gene polymorphism using whole-genome sequencing (WGS). Susceptibility to zifanocycline and 13 comparators was tested using the broth microdilution method, and the combined effects of zifanocycline and seven antibacterial drugs were evaluated.
Results: A total of 67 strains of Mycobacterium abscessus were collected and subjected to whole-genome sequencing. Genomic analysis identified 60 strains of Mycobacterium abscessus subsp. abscessus and 7 strains of Mycobacterium abscessus subsp. massiliense. Among the Mycobacterium abscessus subsp. abscessus strains, 57 exhibited the erm41 T28 genotype, whereas the remaining three showed the erm41 C28 genotype. In our study, zifanocycline (MIC50/MIC90, 0.06/0.25 mg/L) demonstrated a 2-fold lower MIC50 and MIC90 compared to tigecycline (MIC50/MIC90, 0.12/0.5 mg/L), and a 4-fold and 2-fold lower MIC50 and MIC90, respectively, compared to omadacycline (MIC50/MIC90, 0.25/0.5 mg/L). In addition to amikacin and linezolid, zifanocycline demonstrated significantly superior antibacterial activity compared with ciprofloxacin, moxifloxacin, trimethoprim–sulfamethoxazole, cefoxitin, doxycycline, imipenem, and clarithromycin. The combination of zifanocycline and the seven antibacterial drugs used for the treatment of Mycobacterium abscessus showed no significant interactions.
Conclusion: Zifanocycline exhibits positive antibacterial activity against Mycobacterium abscessus in vitro and has potential as an alternative agent in multidrug combination therapy regimens for the treatment of this pathogen.
Keywords: Mycobacterium abscessus, in vitro, tetracycline, zifanocycline