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已发表论文
基底细胞癌的不典型表现：上臂的巨大疣状溃疡
Authors Zhang J, Guo Y, Lv C, Li Z, Miao G, Wang L
Received 2 August 2025
Accepted for publication 29 September 2025
Published 4 October 2025 Volume 2025:18 Pages 1279—1283
DOI https://doi.org/10.2147/IMCRJ.S553586
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Vinay Kumar
Jianzhong Zhang,* Ying Guo,* Chao Lv, Zhifeng Li, Guoying Miao, Litao Wang
Department of Dermatology, Affiliated Hospital of Hebei University of Engineering, Handan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guoying Miao, Email guoyingmiao@163.com Litao Wang, Email wlt518@126.com
Abstract: Giant basal cell carcinoma (GBCC) is a rare and clinically aggressive subtype of BCC. We report an unusual case of a 71-year-old male with a 30-year history of a slowly enlarging tumor on the extensor surface of his left upper arm. The lesion presented as a giant, irregular ulceration measuring 12× 10 cm with coalescing verrucous borders. Histopathological examination confirmed the diagnosis, revealing characteristic nests of basaloid cells with peripheral palisading and stromal retraction artifact in the dermis. Immunohistochemical staining was positive for Ber-EP4, CK15, Ki-67, Bcl-2. The patient was diagnosed with GBCC with Ulcer. Staging workup with computed tomography (CT) of the left humerus and axillary lymph node ultrasonography showed no evidence of metastasis. The patient was successfully treated with slow Mohs micrographic surgery. Subsequent histopathological assessment of the excised specimen confirmed tumor-free margins. At 12-month follow-up, no local recurrence was observed. This case highlights the importance of recognizing GBCC in uncommon locations and demonstrates the efficacy of slow Mohs technique for achieving complete excision in large, complex tumors.
Keywords: basal cell carcinoma, BCC, slow Mohs micrographic surgery, metastasis, standardized follow-up
Department of Dermatology, Affiliated Hospital of Hebei University of Engineering, Handan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guoying Miao, Email guoyingmiao@163.com Litao Wang, Email wlt518@126.com
Abstract: Giant basal cell carcinoma (GBCC) is a rare and clinically aggressive subtype of BCC. We report an unusual case of a 71-year-old male with a 30-year history of a slowly enlarging tumor on the extensor surface of his left upper arm. The lesion presented as a giant, irregular ulceration measuring 12× 10 cm with coalescing verrucous borders. Histopathological examination confirmed the diagnosis, revealing characteristic nests of basaloid cells with peripheral palisading and stromal retraction artifact in the dermis. Immunohistochemical staining was positive for Ber-EP4, CK15, Ki-67, Bcl-2. The patient was diagnosed with GBCC with Ulcer. Staging workup with computed tomography (CT) of the left humerus and axillary lymph node ultrasonography showed no evidence of metastasis. The patient was successfully treated with slow Mohs micrographic surgery. Subsequent histopathological assessment of the excised specimen confirmed tumor-free margins. At 12-month follow-up, no local recurrence was observed. This case highlights the importance of recognizing GBCC in uncommon locations and demonstrates the efficacy of slow Mohs technique for achieving complete excision in large, complex tumors.
Keywords: basal cell carcinoma, BCC, slow Mohs micrographic surgery, metastasis, standardized follow-up