108139
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
虚拟现实干预措施对脊髓损伤相关神经病理性疼痛的影响：多维结局的全面范围综述
Authors Li Q, Du X , Zhao D, Zhang S, Liu M, Ding N, Li Y, Xing Z, Chu X, Chen L
Received 16 June 2025
Accepted for publication 21 September 2025
Published 3 October 2025 Volume 2025:18 Pages 5175—5190
DOI https://doi.org/10.2147/JPR.S547243
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor King Hei Stanley Lam
Qi Li,1,* Xinyu Du,2,* Donglin Zhao,2 Shuyang Zhang,2 Minqi Liu,2 Ning Ding,2 Yajie Li,2 Zheng Xing,1 Xiaolei Chu,1 Long Chen3
1Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, People’s Republic of China; 2Academy of Exercise and Health, Tianjin University of Sport, Tianjin, People’s Republic of China; 3Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaolei Chu, Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, People’s Republic of China, Email chuxiaolei8@tju.edu.cn Long Chen, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People’s Republic of China, Email cagor@tju.edu.cn
Background: Virtual reality (VR) technology represents a novel non-pharmacological intervention demonstrating unique advantages in treating neuropathic pain (NP) following spinal cord injury (SCI). However, systematic clinical guidelines for its application remain lacking.
Objective: To systematically sort out the application patterns of VR in SCI-NP treatment, elucidate its underlying mechanisms of action, evaluate its advantages and limitations, and provide evidence-based recommendations for SCI-NP rehabilitation practice.
Methods: Following PRISMA scoping review protocols, we conducted a comprehensive search. Relevant literature was retrieved from PubMed, Cochrane Library databases, and Web of Science spanning from January 2005 to February 2025, using search terms including “virtual reality”, “VR”, “virtual walking”, “spinal cord injury/SCI”, “neuropathic pain”, “central pain”, “neuralgia”, “chronic pain”, and “pain.” Studies examining VR applications in SCI-NP, including experimental and clinical investigations, were included. Narrative synthesis was employed to summarize VR application characteristics and therapeutic outcomes.
Results: Of the 126 articles retrieved, we included 15 articles involving more than 400 participants. Research designs encompassed randomized controlled trials (n=8), clinical trials (n=2), pilot studies (n=2), feasibility studies (n=2), and exploratory study (n=1). Assessment parameters included pain intensity, pain characteristics, pain interference, emotional status, and immersion experience. Twelve of 15 studies reported significant improvements in neuropathic pain intensity, while most studies assessing pain characteristics, pain Interference, emotional status and intervention quality demonstrated positive effects. However, given the methodological constraints of most studies, such as limited sample sizes, incomplete assessment measures, and insufficient follow-up durations, the widespread use and long-term effectiveness of VR intervention still require further validation.
Conclusion: Current evidence suggests VR technology may serve as an effective adjunct to, rather than replacement for, conventional treatment. Despite limited evidence, VR demonstrates promising analgesic efficacy and emotional enhancement potential in SCI-NP management. Critical knowledge gaps were identified regarding intervention modalities, treatment duration, and participant characteristics, providing recommendations for future research focusing on intervention protocol standardization, outcome measure harmonization, and mechanistic understanding advancement.
Keywords: spinal cord injury, central pain, chronic pain, immersive technology, pain management, scoping review
1Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, People’s Republic of China; 2Academy of Exercise and Health, Tianjin University of Sport, Tianjin, People’s Republic of China; 3Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaolei Chu, Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, People’s Republic of China, Email chuxiaolei8@tju.edu.cn Long Chen, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People’s Republic of China, Email cagor@tju.edu.cn
Background: Virtual reality (VR) technology represents a novel non-pharmacological intervention demonstrating unique advantages in treating neuropathic pain (NP) following spinal cord injury (SCI). However, systematic clinical guidelines for its application remain lacking.
Objective: To systematically sort out the application patterns of VR in SCI-NP treatment, elucidate its underlying mechanisms of action, evaluate its advantages and limitations, and provide evidence-based recommendations for SCI-NP rehabilitation practice.
Methods: Following PRISMA scoping review protocols, we conducted a comprehensive search. Relevant literature was retrieved from PubMed, Cochrane Library databases, and Web of Science spanning from January 2005 to February 2025, using search terms including “virtual reality”, “VR”, “virtual walking”, “spinal cord injury/SCI”, “neuropathic pain”, “central pain”, “neuralgia”, “chronic pain”, and “pain.” Studies examining VR applications in SCI-NP, including experimental and clinical investigations, were included. Narrative synthesis was employed to summarize VR application characteristics and therapeutic outcomes.
Results: Of the 126 articles retrieved, we included 15 articles involving more than 400 participants. Research designs encompassed randomized controlled trials (n=8), clinical trials (n=2), pilot studies (n=2), feasibility studies (n=2), and exploratory study (n=1). Assessment parameters included pain intensity, pain characteristics, pain interference, emotional status, and immersion experience. Twelve of 15 studies reported significant improvements in neuropathic pain intensity, while most studies assessing pain characteristics, pain Interference, emotional status and intervention quality demonstrated positive effects. However, given the methodological constraints of most studies, such as limited sample sizes, incomplete assessment measures, and insufficient follow-up durations, the widespread use and long-term effectiveness of VR intervention still require further validation.
Conclusion: Current evidence suggests VR technology may serve as an effective adjunct to, rather than replacement for, conventional treatment. Despite limited evidence, VR demonstrates promising analgesic efficacy and emotional enhancement potential in SCI-NP management. Critical knowledge gaps were identified regarding intervention modalities, treatment duration, and participant characteristics, providing recommendations for future research focusing on intervention protocol standardization, outcome measure harmonization, and mechanistic understanding advancement.
Keywords: spinal cord injury, central pain, chronic pain, immersive technology, pain management, scoping review