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已发表论文
急性缺血性卒中患者接受血管内治疗后无效再通及并发症的发生：C 反应蛋白 - 白蛋白 - 淋巴细胞（CALLY）指数的预测价值
Authors Zhu L, Jie S, Wu S, Chen Q, Zhang X , Yang W, Wu Y
Received 22 April 2025
Accepted for publication 8 October 2025
Published 22 October 2025 Volume 2025:18 Pages 14649—14661
DOI https://doi.org/10.2147/JIR.S535881
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rongxue Wu
Lin Zhu,1 Sanming Jie,1 Shuhua Wu,1 Qin Chen,1 Xuhui Zhang,1 Wenwu Yang,2 Yongming Wu1
1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Neurosurgery, the 981 Hospital of the Chinese People’s Liberation Army, Chengde, People’s Republic of China
Correspondence: Wenwu Yang, Department of Neurosurgery, the 981 Hospital of the Chinese People’s Liberation Army, Puning Road, Shuangqiao District, Chengde, 067000, People’s Republic of China, Email yangwenwu266@163.com Yongming Wu, Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou North Avenue 1838#, Guangzhou, 510515, People’s Republic of China, Tel +86 13711530187, Email yongmingwucn@hotmail.com
Purpose: The C-reactive protein–albumin–lymphocyte (CALLY) index, as a composite biomarker reflecting nutritional reserves and immunosuppression, has demonstrated important predictive value in various disease. We aimed to investigate the CALLY index’s predictive value versus previous inflammatory-nutritional biomarker for ineffective recanalization and complications in acute ischemic stroke (AIS) patients who received emergency endovascular therapy (EVT).
Methods: We retrospectively reviewed 705 AIS patients admitted to Nanfang Hospital for EVT from January 2019 to December 2023. We calculated the CALLY index, Geriatric Nutritional Risk Index, Controlling Nutritional Status score, Prognostic Nutritional Index, and C-reactive protein-to-albumin ratio, and assessed their predictive significance for ineffective recanalization using univariate and multivariate logistic regression. Predictive efficacy was compared via receiver operating characteristic (ROC) curve analysis, while the Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI) quantified the incremental value of models incorporating these biomarkers. In addition, we explored the relationship between the CALLY index and post-EVT complications.
Results: The CALLY index had the best predictive validity with an area under the ROC curve of 0.73. The new model incorporating the CALLY index had the best optimization effect (NRI of 0.157, P=0.028; IDI of 0.029, P=0.008). A significant correlation was also shown between the CALLY index and stroke-associated pneumonia.
Conclusion: The CALLY Index demonstrated its potential as an innovative and accessible indicator for prognosis.
Keywords: acute ischemic stroke, prognosis, biomarker, stroke-associated pneumonia, nutrition, inflammation
1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Neurosurgery, the 981 Hospital of the Chinese People’s Liberation Army, Chengde, People’s Republic of China
Correspondence: Wenwu Yang, Department of Neurosurgery, the 981 Hospital of the Chinese People’s Liberation Army, Puning Road, Shuangqiao District, Chengde, 067000, People’s Republic of China, Email yangwenwu266@163.com Yongming Wu, Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou North Avenue 1838#, Guangzhou, 510515, People’s Republic of China, Tel +86 13711530187, Email yongmingwucn@hotmail.com
Purpose: The C-reactive protein–albumin–lymphocyte (CALLY) index, as a composite biomarker reflecting nutritional reserves and immunosuppression, has demonstrated important predictive value in various disease. We aimed to investigate the CALLY index’s predictive value versus previous inflammatory-nutritional biomarker for ineffective recanalization and complications in acute ischemic stroke (AIS) patients who received emergency endovascular therapy (EVT).
Methods: We retrospectively reviewed 705 AIS patients admitted to Nanfang Hospital for EVT from January 2019 to December 2023. We calculated the CALLY index, Geriatric Nutritional Risk Index, Controlling Nutritional Status score, Prognostic Nutritional Index, and C-reactive protein-to-albumin ratio, and assessed their predictive significance for ineffective recanalization using univariate and multivariate logistic regression. Predictive efficacy was compared via receiver operating characteristic (ROC) curve analysis, while the Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI) quantified the incremental value of models incorporating these biomarkers. In addition, we explored the relationship between the CALLY index and post-EVT complications.
Results: The CALLY index had the best predictive validity with an area under the ROC curve of 0.73. The new model incorporating the CALLY index had the best optimization effect (NRI of 0.157, P=0.028; IDI of 0.029, P=0.008). A significant correlation was also shown between the CALLY index and stroke-associated pneumonia.
Conclusion: The CALLY Index demonstrated its potential as an innovative and accessible indicator for prognosis.
Keywords: acute ischemic stroke, prognosis, biomarker, stroke-associated pneumonia, nutrition, inflammation