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已发表论文
苯二氮䓬类药物在阿片类药物使用障碍患者中的应用：综述性文献回顾
Authors Liu Y , Hong Q, Xie X , Shen W , Chen W, Liu H, Zhou W
Received 2 July 2025
Accepted for publication 8 October 2025
Published 21 October 2025 Volume 2025:16 Pages 283—291
DOI https://doi.org/10.2147/SAR.S550775
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Rajendra Badgaiyan
Yue Liu,1,2 Qingxiao Hong,2 Xiaohu Xie,2 Wenwen Shen,1,2 Weisheng Chen,2 Huifen Liu,2 Wenhua Zhou2
1Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, 315201, People’s Republic of China; 2Zhejiang Key Laboratory of Drug Addiction and Brain Health, Ningbo, Zhejiang, 315201, People’s Republic of China
Correspondence: Wenhua Zhou, Zhejiang Key Laboratory of Drug Addiction and Brain Health, No. 1, Zhuangyu South Road, Zhuangshi Street, Zhenhai District, Ningbo, Zhejiang, 315201, People’s Republic of China, Email whzhou@vip.163.com Huifen Liu, Zhejiang Key Laboratory of Drug Addiction and Brain Health, No. 1, Zhuangyu South Road, Zhuangshi Street, Zhenhai District, Ningbo, Zhejiang, 315201, People’s Republic of China, Email Lihufen@163.com
Abstract: The concomitant use of benzodiazepines (BZDs) among individuals with opioid use disorder (OUD) is highly prevalent, with a rapid annual increase in overdose-related deaths. The co-use of BZDs is a significant predictor of opioid overdose. In the absence of other drugs, BZDs are rarely the sole cause of death. Prolonged BZD use frequently results in the rapid development of tolerance and dependence. A strong association has also been established between BZD misuse and depression. Moreover, chronic BZD exposure is linked to cognitive impairments, psychomotor disturbance, delirium, and an increased risk of falls, fractures, injuries, and traffic accidents. Outpatient clinicians should routinely screen for concurrent BZD use and exercise caution in prescribing. Timely interventions—including patient education, gradual discontinuation, psychological therapies, and skills-based training—are critical to mitigating harm and improving prognosis. In addition, Traditional Chinese Medicine(TCM), including herbal prescriptions and acupuncture, may serve as promising non-addictive alternatives for the management of anxiety, insomnia, and withdrawal-related symptoms. Strengthening multifaceted efforts will be crucial for reducing the burden of BZD use and improving treatment outcomes in OUD.
Keywords: benzodiazepines, opioids, abuse, overdose
1Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, 315201, People’s Republic of China; 2Zhejiang Key Laboratory of Drug Addiction and Brain Health, Ningbo, Zhejiang, 315201, People’s Republic of China
Correspondence: Wenhua Zhou, Zhejiang Key Laboratory of Drug Addiction and Brain Health, No. 1, Zhuangyu South Road, Zhuangshi Street, Zhenhai District, Ningbo, Zhejiang, 315201, People’s Republic of China, Email whzhou@vip.163.com Huifen Liu, Zhejiang Key Laboratory of Drug Addiction and Brain Health, No. 1, Zhuangyu South Road, Zhuangshi Street, Zhenhai District, Ningbo, Zhejiang, 315201, People’s Republic of China, Email Lihufen@163.com
Abstract: The concomitant use of benzodiazepines (BZDs) among individuals with opioid use disorder (OUD) is highly prevalent, with a rapid annual increase in overdose-related deaths. The co-use of BZDs is a significant predictor of opioid overdose. In the absence of other drugs, BZDs are rarely the sole cause of death. Prolonged BZD use frequently results in the rapid development of tolerance and dependence. A strong association has also been established between BZD misuse and depression. Moreover, chronic BZD exposure is linked to cognitive impairments, psychomotor disturbance, delirium, and an increased risk of falls, fractures, injuries, and traffic accidents. Outpatient clinicians should routinely screen for concurrent BZD use and exercise caution in prescribing. Timely interventions—including patient education, gradual discontinuation, psychological therapies, and skills-based training—are critical to mitigating harm and improving prognosis. In addition, Traditional Chinese Medicine(TCM), including herbal prescriptions and acupuncture, may serve as promising non-addictive alternatives for the management of anxiety, insomnia, and withdrawal-related symptoms. Strengthening multifaceted efforts will be crucial for reducing the burden of BZD use and improving treatment outcomes in OUD.
Keywords: benzodiazepines, opioids, abuse, overdose