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已发表论文
肠道菌群失调所致炎症的生物标志物定量检测：综述
Authors Lin L, George J , Liu G
Received 8 May 2025
Accepted for publication 26 September 2025
Published 21 October 2025 Volume 2025:18 Pages 14551—14567
DOI https://doi.org/10.2147/JIR.S539155
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Fatih Türker
Leqi Lin,1 Jacob George,2 Guozhen Liu1
1Integrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHKSZ-Boyalife Regenerative Medicine Engineering Joint Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, People’s Republic of China; 2Storr Liver Centre, Westmead Institute of Medical Research, University of Sydney and Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, 2145, Australia
Correspondence: Guozhen Liu, Email liuguozhen@cuhk.edu.cn
Abstract: Gut dysbiosis, an alteration or imbalance in the composition and function of the gut microbiome can lead to a range of health issues. Inflammation in this setting leads to increased permeability of the intestinal barrier and the activation of immune responses which contributes to a range of inflammatory, autoimmune and metabolic diseases. Therefore, precise quantification of gut-derived inflammation is important to gain insights into the development and progression these diseases and to develop treatments. This review highlights the underlying mechanisms leading to gut inflammation and the markers of gut dysbiosis mediated inflammation. We then discuss strategies including disposable and wearable biosensing devices, biomedical imaging, sequencing and AI-based methods for the quantification of dysbiosis-derived inflammation. Challenges and future perspectives for quantification of gut dysbiosis mediated inflammation are proposed.
Keywords: gut dysbiosis, inflammation, lipopolysaccharide, cytokines, disposable device, ingestible devices
1Integrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHKSZ-Boyalife Regenerative Medicine Engineering Joint Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, People’s Republic of China; 2Storr Liver Centre, Westmead Institute of Medical Research, University of Sydney and Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, 2145, Australia
Correspondence: Guozhen Liu, Email liuguozhen@cuhk.edu.cn
Abstract: Gut dysbiosis, an alteration or imbalance in the composition and function of the gut microbiome can lead to a range of health issues. Inflammation in this setting leads to increased permeability of the intestinal barrier and the activation of immune responses which contributes to a range of inflammatory, autoimmune and metabolic diseases. Therefore, precise quantification of gut-derived inflammation is important to gain insights into the development and progression these diseases and to develop treatments. This review highlights the underlying mechanisms leading to gut inflammation and the markers of gut dysbiosis mediated inflammation. We then discuss strategies including disposable and wearable biosensing devices, biomedical imaging, sequencing and AI-based methods for the quantification of dysbiosis-derived inflammation. Challenges and future perspectives for quantification of gut dysbiosis mediated inflammation are proposed.
Keywords: gut dysbiosis, inflammation, lipopolysaccharide, cytokines, disposable device, ingestible devices