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已发表论文
丙泊酚对择期剖宫产脊麻患者术后睡眠质量的影响：一项单中心倾向评分匹配回顾性队列研究
Authors Zhou J , Hu B , Zhang Y, Wang Q, Wu Y, Wang H
Received 13 August 2025
Accepted for publication 24 October 2025
Published 3 November 2025 Volume 2025:17 Pages 2853—2862
DOI https://doi.org/10.2147/NSS.S559802
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Sarah L Appleton
Jie Zhou, Bingwei Hu, Yu Zhang, Qing Wang, Yong Wu, Hongwei Wang
Department of Anesthesiology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Hongwei Wang, Department of Anesthesiology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China, Email wanghw1022@163.com
Purpose: To assess the impact of propofol on postoperative sleep quality in patients undergoing spinal anesthesia for cesarean section.
Patients and Methods: This study included a total of 245 patients, aged over 18 yr, who underwent elective cesarean section under spinal anesthesia from 1 January 2024 to 31 December 2024. Outcomes were compared between the propofol group, which received propofol after infant delivery, and the control group, which received no intravenous anesthetics. Primary and secondary outcomes were postoperative sleep quality and depressive symptoms, evaluated using the Pittsburgh Sleep Quality Index (PSQI) and Edinburgh Postnatal Depression Scale (EPDS) at 30 days post-surgery. Propensity-score matching ensured balanced baseline characteristics.
Results: Following propensity score matching, 29 patients per group were included in this study. After matching, the propofol group showed significantly lower PSQI scores (8.3 ± 3.4 vs 10.9 ± 3.1; mean difference − 2.6, 95% CI: − 3.1 to − 2.1; P< 0.001) and lower EPDS scores (7.9 ± 3.0 vs 10.2 ± 3.1; mean difference − 2.3, 95% CI: − 3.0 to − 1.7; P< 0.001) compared to the control group on the 30th day after surgery.
Conclusion: : Using propofol following extraction of the infant was associated with lower incidence of postoperative sleep disorders in patients undergoing spinal anesthesia for cesarean section.
Clinical Trial Registration Number: ChiCTR2500097811.
Registration Date: 02/26/2025.
Keywords: postpartum sleep disorder, cesarean section, pittsburgh sleep quality index, propofol
Department of Anesthesiology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Hongwei Wang, Department of Anesthesiology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China, Email wanghw1022@163.com
Purpose: To assess the impact of propofol on postoperative sleep quality in patients undergoing spinal anesthesia for cesarean section.
Patients and Methods: This study included a total of 245 patients, aged over 18 yr, who underwent elective cesarean section under spinal anesthesia from 1 January 2024 to 31 December 2024. Outcomes were compared between the propofol group, which received propofol after infant delivery, and the control group, which received no intravenous anesthetics. Primary and secondary outcomes were postoperative sleep quality and depressive symptoms, evaluated using the Pittsburgh Sleep Quality Index (PSQI) and Edinburgh Postnatal Depression Scale (EPDS) at 30 days post-surgery. Propensity-score matching ensured balanced baseline characteristics.
Results: Following propensity score matching, 29 patients per group were included in this study. After matching, the propofol group showed significantly lower PSQI scores (8.3 ± 3.4 vs 10.9 ± 3.1; mean difference − 2.6, 95% CI: − 3.1 to − 2.1; P< 0.001) and lower EPDS scores (7.9 ± 3.0 vs 10.2 ± 3.1; mean difference − 2.3, 95% CI: − 3.0 to − 1.7; P< 0.001) compared to the control group on the 30th day after surgery.
Conclusion: : Using propofol following extraction of the infant was associated with lower incidence of postoperative sleep disorders in patients undergoing spinal anesthesia for cesarean section.
Clinical Trial Registration Number: ChiCTR2500097811.
Registration Date: 02/26/2025.
Keywords: postpartum sleep disorder, cesarean section, pittsburgh sleep quality index, propofol