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已发表论文
伤口愈合：利用脂肪源性干细胞衍生的细胞外囊泡
Authors Liu Q , Zhang C, Liang Y , Pan X
Received 12 June 2025
Accepted for publication 16 October 2025
Published 1 November 2025 Volume 2025:20 Pages 13209—13229
DOI https://doi.org/10.2147/IJN.S546521
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Jie Huang
Qisong Liu,1 Cuiping Zhang,2 Yujie Liang,1 Xiaohua Pan1
1Department of Orthopaedics and Traumatology, the Second Affiliated Hospital of Shenzhen University (People’s Hospital of Shenzhen Baoan District), Shenzhen, Guangdong Province, People’s Republic of China; 2Medical Innovation Research Department (Affiliated Research Center for Tissue Repair and Regeneration), PLA General Hospital, Beijing, People’s Republic of China
Correspondence: Yujie Liang, Email liangyjie@126.com Xiaohua Pan, Email szpxh4141@foxmail.com
Abstract: Chronic wounds present a significant clinical challenge, placing a heavy burden on patients and highlighting the need for more effective treatments. Among emerging strategies, adipose-derived stem cells (ADSCs) and their extracellular vesicles (ADSC-EVs) show great promise due to their potent wound-healing capabilities. Clinical evidence indicates that ADSC transplantation effectively promotes healing across diverse chronic wound types, improving healing quality while reducing pathological scarring. As key paracrine mediators of ADSCs, ADSC-EVs have garnered considerable interest for their advantages in therapeutic development and reparative functions. ADSC-EVs precisely modulate critical cells within the wound microenvironment, including keratinocytes, macrophages, endothelial cells, and fibroblasts. This modulation promotes re-epithelialization, resolves inflammation, stimulates angiogenesis, and modulates extracellular matrix remodeling. These regulatory effects are attributed to the rich cargo of bioactive molecules carried by ADSC-EVs, including proteins and non-coding RNAs. Notably, preconditioning strategies and functional delivery materials can further enhance the modulatory effects of ADSC-EVs by enriching them with specific therapeutic molecules and enabling controlled release. Furthermore, ADSC-EVs serve as efficient drug delivery vehicles for exogenous therapeutics, enabling synergistic effects. In summary, both ADSCs and ADSC-EVs demonstrate considerable clinical potential for chronic wound management.
Keywords: diabetic wound, scar formation, ECM remodeling, angiogenesis
1Department of Orthopaedics and Traumatology, the Second Affiliated Hospital of Shenzhen University (People’s Hospital of Shenzhen Baoan District), Shenzhen, Guangdong Province, People’s Republic of China; 2Medical Innovation Research Department (Affiliated Research Center for Tissue Repair and Regeneration), PLA General Hospital, Beijing, People’s Republic of China
Correspondence: Yujie Liang, Email liangyjie@126.com Xiaohua Pan, Email szpxh4141@foxmail.com
Abstract: Chronic wounds present a significant clinical challenge, placing a heavy burden on patients and highlighting the need for more effective treatments. Among emerging strategies, adipose-derived stem cells (ADSCs) and their extracellular vesicles (ADSC-EVs) show great promise due to their potent wound-healing capabilities. Clinical evidence indicates that ADSC transplantation effectively promotes healing across diverse chronic wound types, improving healing quality while reducing pathological scarring. As key paracrine mediators of ADSCs, ADSC-EVs have garnered considerable interest for their advantages in therapeutic development and reparative functions. ADSC-EVs precisely modulate critical cells within the wound microenvironment, including keratinocytes, macrophages, endothelial cells, and fibroblasts. This modulation promotes re-epithelialization, resolves inflammation, stimulates angiogenesis, and modulates extracellular matrix remodeling. These regulatory effects are attributed to the rich cargo of bioactive molecules carried by ADSC-EVs, including proteins and non-coding RNAs. Notably, preconditioning strategies and functional delivery materials can further enhance the modulatory effects of ADSC-EVs by enriching them with specific therapeutic molecules and enabling controlled release. Furthermore, ADSC-EVs serve as efficient drug delivery vehicles for exogenous therapeutics, enabling synergistic effects. In summary, both ADSCs and ADSC-EVs demonstrate considerable clinical potential for chronic wound management.
Keywords: diabetic wound, scar formation, ECM remodeling, angiogenesis