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已发表论文
急性缺血性脑卒中患者入院时血浆同型半胱氨酸水平和估算肾小球滤过率对神经功能的影响：一项回顾性横断面研究
Authors Quan A, Guo S, Jiang Y, Wei W, Jiao M, Yue X, Sun M, Lang L, Bao M, Shang L
Received 31 July 2025
Accepted for publication 15 October 2025
Published 31 October 2025 Volume 2025:21 Pages 2427—2436
DOI https://doi.org/10.2147/NDT.S552057
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Aijun Quan,1 Sihui Guo,1 Ying Jiang,1 Wei Wei,2 Minna Jiao,1 Xinxin Yue,1 Manchao Sun,1 Lu Lang,1 Mengxue Bao,1 Lili Shang3,4
1Department of Critical Care Rehabilitation/Department of Critical Care Medicine, the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China; 2Department of Radiology, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China; 3Department of Nephrology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, 100038, People’s Republic of China; 4Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China
Correspondence: Lili Shang, Email cvfsbi@163.com
Objective: To investigate the effects of homocysteine (Hcy) and estimated glomerular filtration rate (eGFR) on neurological function in patients with ischemic stroke (IS) on admission.
Methods: 248 IS patients admitted to the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2023 to January 2025 were studied. Basic information, disease history, laboratory test indicators and other information of patients were recorded at admission. According to admission mRS scores, patients were divided into two groups: the control group with good neurological function (mRS 0– 1) and the neurological dysfunction group (mRS 2– 5). The relationship between Hcy and eGFR on the neurological function of IS patients at admission was analyzed using a multivariate logistic regression model and an additive interaction model.
Results: Among 248 patients, there were 118 patients with neurological dysfunction and 130 patients with good neurological function. After adjusting for confounding factors, it was found that eGFR and Hcy were independent influencing factors of neurological function in IS patients on admission (P < 0.05). The risk of neurological dysfunction in patients with elevated Hcy and decreased eGFR on admission was 4.28 times higher than that in patients with both indicators normal [OR = 4.28 (95% CI2.62– 7.24), P < 0.001)]. There was a significant negative correlation between HCY and eGFR, and Hcy and eGFR had an additive interaction effect on the risk of neurological dysfunction on admission (RERI = 2.02, 95% CI0.02– 4.01; AP = 0.45, 95% CI0.13– 0.79).
Conclusion: Hcy and eGFR are the influencing factors of neurological dysfunction in IS patients, and the two are significantly negatively correlated with the risk of neurological dysfunction in IS patients, and there is an additive interaction.
Keywords: ischemic stroke, homocysteine, glomerular filtration rate, neurological function recovery
1Department of Critical Care Rehabilitation/Department of Critical Care Medicine, the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China; 2Department of Radiology, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China; 3Department of Nephrology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, 100038, People’s Republic of China; 4Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150036, People’s Republic of China
Correspondence: Lili Shang, Email cvfsbi@163.com
Objective: To investigate the effects of homocysteine (Hcy) and estimated glomerular filtration rate (eGFR) on neurological function in patients with ischemic stroke (IS) on admission.
Methods: 248 IS patients admitted to the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2023 to January 2025 were studied. Basic information, disease history, laboratory test indicators and other information of patients were recorded at admission. According to admission mRS scores, patients were divided into two groups: the control group with good neurological function (mRS 0– 1) and the neurological dysfunction group (mRS 2– 5). The relationship between Hcy and eGFR on the neurological function of IS patients at admission was analyzed using a multivariate logistic regression model and an additive interaction model.
Results: Among 248 patients, there were 118 patients with neurological dysfunction and 130 patients with good neurological function. After adjusting for confounding factors, it was found that eGFR and Hcy were independent influencing factors of neurological function in IS patients on admission (P < 0.05). The risk of neurological dysfunction in patients with elevated Hcy and decreased eGFR on admission was 4.28 times higher than that in patients with both indicators normal [OR = 4.28 (95% CI2.62– 7.24), P < 0.001)]. There was a significant negative correlation between HCY and eGFR, and Hcy and eGFR had an additive interaction effect on the risk of neurological dysfunction on admission (RERI = 2.02, 95% CI0.02– 4.01; AP = 0.45, 95% CI0.13– 0.79).
Conclusion: Hcy and eGFR are the influencing factors of neurological dysfunction in IS patients, and the two are significantly negatively correlated with the risk of neurological dysfunction in IS patients, and there is an additive interaction.
Keywords: ischemic stroke, homocysteine, glomerular filtration rate, neurological function recovery