109906
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
磁性惊厥疗法与电休克疗法在精神分裂症中的比较：前额叶-杏仁核可塑性及认知安全性
Authors Li J, Jin T, Chi Y, Chen J, Gao J, Yang Y , Tian Q, Zhang X, Zheng L
Received 18 May 2025
Accepted for publication 20 October 2025
Published 31 October 2025 Volume 2025:21 Pages 2415—2425
DOI https://doi.org/10.2147/NDT.S531892
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Yu-Ping Ning
Jin Li,1,2,* Tingting Jin,1,* Yuyan Chi,1,* Jie Chen,1,* Ju Gao,1 Yong Yang,1 Qing Tian,1 Xiaobin Zhang,1,* Limei Zheng3,*
1Department of Psychiatry, Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Shanghai Mental Health Center, Shanghai, People’s Republic of China; 3Department of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Limei Zheng, Department of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China, Email 530272229@qq.com
Purpose: Reducing electroconvulsive therapy (ECT)’s cognitive burden without compromising efficacy is critical. Although magnetic seizure therapy (MST) shows comparable symptom remission in schizophrenia, its neuroanatomical safety—particularly limbic preservation—lacks controlled trial validation.
Patients and Methods: This triple-blind RCT (NCT02746965) randomized 34 schizophrenia patients to ECT (n=16) or MST (n=18). Structural changes were quantified via 3T MRI (FreeSurfer). Outcomes included Positive and Negative Syndrome Scale (PANSS), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and generalized linear mixed-effects models with FDR correction (q< 0.1).
Results: Both groups achieved comparable PANSS reduction (ECT: Δ=− 38.2± 5.1 vs MST: Δ=− 35.7± 6.4, p=0.12). MST showed superior cognitive preservation vs ECT in language (Δ=+7.2 vs ECT: Δ=− 3.1; Cohen′s d=1.15, p=0.003) and delayed memory (Δ=+5.8 vs +1.2, p=0.04). Nonsignificant between-group differences in amygdala volume changes (ECT: Δ= − 1.2% vs − 0.9%, p = 0.31).
Conclusion: As the first RCT mapping neuroanatomical changes of convulsive therapies in schizophrenia, we establish MST’s cognitive safety via prefrontal-amygdala plasticity—a novel mechanism preserving language and memory functions.
Plain Language Summary: What we studied
For severe schizophrenia where medications fail, we compared electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). MST uses magnets instead of electricity and may cause fewer memory issues. This first brain-imaging randomized trial examined:
1. Effects on memory-related brain structures
2. Impacts on thinking skills
How we studied it
34 participants received ECT (16) or MST (18) for 4 weeks. We measured symptom improvement, memory/language skills and brain changes via MRI.
Key findings
• Both treatments reduced symptoms equally
• MST caused significantly fewer language problems than ECT
• Neither treatment changed amygdala size
Why it matters
MST works as well as ECT while better protecting language abilities—helping patients communicate during recovery. MST offers a safer alternative that preserves critical thinking.
Note: These results from 34 participants need larger trials for confirmation.
Keywords: neuromodulation safety, seizure therapy optimization, prefrontal-amygdala axis, therapeutic cognitive index, treatment-resistant psychosis
1Department of Psychiatry, Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Shanghai Mental Health Center, Shanghai, People’s Republic of China; 3Department of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Limei Zheng, Department of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China, Email 530272229@qq.com
Purpose: Reducing electroconvulsive therapy (ECT)’s cognitive burden without compromising efficacy is critical. Although magnetic seizure therapy (MST) shows comparable symptom remission in schizophrenia, its neuroanatomical safety—particularly limbic preservation—lacks controlled trial validation.
Patients and Methods: This triple-blind RCT (NCT02746965) randomized 34 schizophrenia patients to ECT (n=16) or MST (n=18). Structural changes were quantified via 3T MRI (FreeSurfer). Outcomes included Positive and Negative Syndrome Scale (PANSS), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and generalized linear mixed-effects models with FDR correction (q< 0.1).
Results: Both groups achieved comparable PANSS reduction (ECT: Δ=− 38.2± 5.1 vs MST: Δ=− 35.7± 6.4, p=0.12). MST showed superior cognitive preservation vs ECT in language (Δ=+7.2 vs ECT: Δ=− 3.1; Cohen′s d=1.15, p=0.003) and delayed memory (Δ=+5.8 vs +1.2, p=0.04). Nonsignificant between-group differences in amygdala volume changes (ECT: Δ= − 1.2% vs − 0.9%, p = 0.31).
Conclusion: As the first RCT mapping neuroanatomical changes of convulsive therapies in schizophrenia, we establish MST’s cognitive safety via prefrontal-amygdala plasticity—a novel mechanism preserving language and memory functions.
Plain Language Summary: What we studied
For severe schizophrenia where medications fail, we compared electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). MST uses magnets instead of electricity and may cause fewer memory issues. This first brain-imaging randomized trial examined:
1. Effects on memory-related brain structures
2. Impacts on thinking skills
How we studied it
34 participants received ECT (16) or MST (18) for 4 weeks. We measured symptom improvement, memory/language skills and brain changes via MRI.
Key findings
• Both treatments reduced symptoms equally
• MST caused significantly fewer language problems than ECT
• Neither treatment changed amygdala size
Why it matters
MST works as well as ECT while better protecting language abilities—helping patients communicate during recovery. MST offers a safer alternative that preserves critical thinking.
Note: These results from 34 participants need larger trials for confirmation.
Keywords: neuromodulation safety, seizure therapy optimization, prefrontal-amygdala axis, therapeutic cognitive index, treatment-resistant psychosis