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已发表论文
新型 LAM 检测法在结核病检测中显示出令人满意的结果
Authors Luo X, Xin K, Lai F, Xie Z, Pang X, Huang Y, Ma Q, Zheng Y, Luo X, Liu H
Received 4 August 2025
Accepted for publication 3 November 2025
Published 14 November 2025 Volume 2025:18 Pages 5939—5947
DOI https://doi.org/10.2147/IDR.S558357
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Xiaolu Luo,1,* Keke Xin,2,* Feie Lai,3,* Zhouhua Xie,4,* Xiaolu Pang,1 Yuliang Huang,1 Qiuying Ma,1 Yanqing Zheng,1 Xiaocheng Luo,5 Huaying Liu2
1Department of Infectious Disease Research Laboratory, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 2Department of Medicine, GuangXi Health Science College, Nanning, 530021, People’s Republic of China; 3Department of Teacher Development, GuangXi Health Science College, Nanning, 530021, People’s Republic of China; 4Department of Tuberculosis, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 5Department of Clinical Laboratory, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huaying Liu, Department of Medicine, GuangXi Health Science College, Nanning, People’s Republic of China, Email liuhy23@163.com Xiaocheng Luo, Department of Clinical Laboratory, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China, Email luoxiaocheng1101@163.com
Background: Diagnosing tuberculosis (TB) infection remains a challenge for clinicians. According to recommendations from the World Health Organization (WHO), lipoarabinomannan (LAM) testing can be used to diagnose TB infection in individuals. A new generation of urinary LAM testing is now available. However, studies on its accuracy are limited and warrant further exploration.
Objective: This study aims to evaluate the accuracy of a new urinary LAM testing using LAM for diagnosing TB infection.
Methods: A cross-sectional study was conducted at the Fourth People’s Hospital of Nanning, China. Participants were enrolled from December 2023 to May 2024. Fresh urine samples were collected from the participants and tested using LAM. The diagnostic accuracy of the LAM was compared with other tests for Mycobacterium tuberculosis (sputum culture, sputum smear or molecular biology testing). We compared the positive rates of different TB detection methods to evaluate the effectiveness of LAM. In the comparative analysis, the 95% confidence interval was calculated using the Wilson score method. The kappa value was computed, and the corresponding P-value was reported.
Results: The positive agreement rate of LAM was 64.37%, the negative agreement rate was 94.29%, and the overall agreement rate was 80.73%. The Kappa value was 0.6013, indicating good consistency between the test reagent and the reference method.
Conclusion: LAM can be used for the diagnosis of TB. It provides diagnostic information quickly, easily, and cost-effectively, particularly showing good performance in diagnosing TB.
Keywords: tuberculosis, lipoarabinomannan, diagnostic accuracy
1Department of Infectious Disease Research Laboratory, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 2Department of Medicine, GuangXi Health Science College, Nanning, 530021, People’s Republic of China; 3Department of Teacher Development, GuangXi Health Science College, Nanning, 530021, People’s Republic of China; 4Department of Tuberculosis, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 5Department of Clinical Laboratory, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huaying Liu, Department of Medicine, GuangXi Health Science College, Nanning, People’s Republic of China, Email liuhy23@163.com Xiaocheng Luo, Department of Clinical Laboratory, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China, Email luoxiaocheng1101@163.com
Background: Diagnosing tuberculosis (TB) infection remains a challenge for clinicians. According to recommendations from the World Health Organization (WHO), lipoarabinomannan (LAM) testing can be used to diagnose TB infection in individuals. A new generation of urinary LAM testing is now available. However, studies on its accuracy are limited and warrant further exploration.
Objective: This study aims to evaluate the accuracy of a new urinary LAM testing using LAM for diagnosing TB infection.
Methods: A cross-sectional study was conducted at the Fourth People’s Hospital of Nanning, China. Participants were enrolled from December 2023 to May 2024. Fresh urine samples were collected from the participants and tested using LAM. The diagnostic accuracy of the LAM was compared with other tests for Mycobacterium tuberculosis (sputum culture, sputum smear or molecular biology testing). We compared the positive rates of different TB detection methods to evaluate the effectiveness of LAM. In the comparative analysis, the 95% confidence interval was calculated using the Wilson score method. The kappa value was computed, and the corresponding P-value was reported.
Results: The positive agreement rate of LAM was 64.37%, the negative agreement rate was 94.29%, and the overall agreement rate was 80.73%. The Kappa value was 0.6013, indicating good consistency between the test reagent and the reference method.
Conclusion: LAM can be used for the diagnosis of TB. It provides diagnostic information quickly, easily, and cost-effectively, particularly showing good performance in diagnosing TB.
Keywords: tuberculosis, lipoarabinomannan, diagnostic accuracy