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已发表论文
磁性纳米粒子在神经再生中调节神经可塑性的机制及研究进展
Authors Liu Y, Zhang Y, Huang Y, Bi X
Received 12 June 2025
Accepted for publication 29 October 2025
Published 14 November 2025 Volume 2025:18 Pages 553—572
DOI https://doi.org/10.2147/NSA.S546693
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Professor Kattesh Katti
Yue Liu,1,2 Yizhuo Zhang,2,3 Yingying Huang,2,3 Xia Bi2
1Sports and Health Institute, Shanghai University of Sport, Shanghai, People’s Republic of China; 2Department of Rehabilitation Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, People’s Republic of China; 3Shanghai University of Medicine & Health Sciences; Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Correspondence: Xia Bi, Department of Rehabilitation Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, People’s Republic of China, Email bixiash@163.com
Abstract: Magnetic nanoparticles (MNPs), particularly those exhibiting superparamagnetism and biocompatibility, have garnered significant interest in the biomedical field due to their unique physicochemical properties. Recent studies have shown that MNPs can modulate neural plasticity by influencing key signaling pathways such as BDNF (Brain-Derived Neurotrophic Factor) and the PI3K/Akt pathway, critical for neuronal growth, synaptic connectivity, and functional recovery. This review provides a comprehensive analysis of the mechanisms through which MNPs interact with neural tissues, highlighting the diversity of nanoparticle types (eg, iron oxide, gold, and carbon-based nanoparticles) and their applications in neurodegenerative disease treatment and neural regeneration. Despite the immense potential of MNPs in neurodegenerative disease treatment, this review also compares them with traditional interventions, discussing their advantages and limitations. Additionally, it addresses key challenges, particularly the difficulty of overcoming the blood-brain barrier, and issues related to biocompatibility, toxicity, and long-term safety. In clinical applications, ethical concerns, such as patient informed consent and long-term risks, must also be considered alongside efficacy and safety. This review offers insights into these challenges and provides a framework for future research, aiming to accelerate the clinical integration of MNP-based neurotherapies.
Keywords: magnetic nanoparticles, neural plasticity, neural signaling pathways, research progress
1Sports and Health Institute, Shanghai University of Sport, Shanghai, People’s Republic of China; 2Department of Rehabilitation Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, People’s Republic of China; 3Shanghai University of Medicine & Health Sciences; Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Correspondence: Xia Bi, Department of Rehabilitation Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, People’s Republic of China, Email bixiash@163.com
Abstract: Magnetic nanoparticles (MNPs), particularly those exhibiting superparamagnetism and biocompatibility, have garnered significant interest in the biomedical field due to their unique physicochemical properties. Recent studies have shown that MNPs can modulate neural plasticity by influencing key signaling pathways such as BDNF (Brain-Derived Neurotrophic Factor) and the PI3K/Akt pathway, critical for neuronal growth, synaptic connectivity, and functional recovery. This review provides a comprehensive analysis of the mechanisms through which MNPs interact with neural tissues, highlighting the diversity of nanoparticle types (eg, iron oxide, gold, and carbon-based nanoparticles) and their applications in neurodegenerative disease treatment and neural regeneration. Despite the immense potential of MNPs in neurodegenerative disease treatment, this review also compares them with traditional interventions, discussing their advantages and limitations. Additionally, it addresses key challenges, particularly the difficulty of overcoming the blood-brain barrier, and issues related to biocompatibility, toxicity, and long-term safety. In clinical applications, ethical concerns, such as patient informed consent and long-term risks, must also be considered alongside efficacy and safety. This review offers insights into these challenges and provides a framework for future research, aiming to accelerate the clinical integration of MNP-based neurotherapies.
Keywords: magnetic nanoparticles, neural plasticity, neural signaling pathways, research progress