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已发表论文
用于胰腺癌协同治疗的多模态成像引导的肿瘤微环境响应型纳米平台
Authors Li N, Hu H, Li Y, Li S , Shi G, Yu X, Hao L
Received 25 May 2025
Accepted for publication 3 November 2025
Published 14 November 2025 Volume 2025:20 Pages 13721—13739
DOI https://doi.org/10.2147/IJN.S542677
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Dong Wang
Na Li,1,2,* Haifeng Hu,2,* Yuqi Li,3 Silong Li,3 Guangyue Shi,1 Xiaoyang Yu,1 Liguo Hao1
1Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, People’s Republic of China; 2Department of Imaging Medicine and Nuclear Medicine, School of Clinical Medicine, Jiamusi University, Jiamusi, Heilongjiang, 154002, People’s Republic of China; 3Medical Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Liguo Hao, Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, No. 333, Bukui North Street, Jianhua District, Qiqihar, Heilongjiang, 161006, People’s Republic of China, Email haoliguo@qmu.edu.cn
Purpose: Chemotherapy remains an effective treatment for pancreatic cancer. However, the limitations of single-modal therapies and the absence of imaging-based monitoring during treatment pose challenges for real-time optimization of drug delivery, resulting in suboptimal therapeutic outcomes.
Methods: This study aims to design and develop a novel nanoparticle drug delivery system, HMP-ICG&DOX, which incorporates indocyanine green (ICG) as an FDA-approved near-infrared photothermal agent and doxorubicin (DOX) as a commonly used chemotherapeutic drug. The modification with NH2-PEG-NH2 enhances the biocompatibility of the nanocarrier. The designed nanoprobe exhibits the following features: (1) It decomposes in the tumor microenvironment (TME) to release Mn2+ for magnetic resonance T1 imaging, while ICG provides near-infrared fluorescence imaging capabilities. (2) It facilitates synergistic photothermal-chemotherapy, significantly improving therapeutic efficacy against pancreatic cancer. (3) The pH-responsive drug release enhances drug utilization efficiency while minimizing side effects.
Results: Experimental results demonstrate that HMP-ICG&DOX nanoparticles possess excellent biocompatibility, antitumor activity, controlled drug release, and multimodal imaging tracking abilities.
Conclusion: In conclusion, the HMP-ICG&DOX nanoparticles designed in this study offer promising applications in the diagnosis and treatment of pancreatic cancer.
Keywords: pancreatic cancer, magnetic resonance imaging, hollow manganese dioxide, indocyanine green, adriamycin
1Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, People’s Republic of China; 2Department of Imaging Medicine and Nuclear Medicine, School of Clinical Medicine, Jiamusi University, Jiamusi, Heilongjiang, 154002, People’s Republic of China; 3Medical Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Liguo Hao, Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, No. 333, Bukui North Street, Jianhua District, Qiqihar, Heilongjiang, 161006, People’s Republic of China, Email haoliguo@qmu.edu.cn
Purpose: Chemotherapy remains an effective treatment for pancreatic cancer. However, the limitations of single-modal therapies and the absence of imaging-based monitoring during treatment pose challenges for real-time optimization of drug delivery, resulting in suboptimal therapeutic outcomes.
Methods: This study aims to design and develop a novel nanoparticle drug delivery system, HMP-ICG&DOX, which incorporates indocyanine green (ICG) as an FDA-approved near-infrared photothermal agent and doxorubicin (DOX) as a commonly used chemotherapeutic drug. The modification with NH2-PEG-NH2 enhances the biocompatibility of the nanocarrier. The designed nanoprobe exhibits the following features: (1) It decomposes in the tumor microenvironment (TME) to release Mn2+ for magnetic resonance T1 imaging, while ICG provides near-infrared fluorescence imaging capabilities. (2) It facilitates synergistic photothermal-chemotherapy, significantly improving therapeutic efficacy against pancreatic cancer. (3) The pH-responsive drug release enhances drug utilization efficiency while minimizing side effects.
Results: Experimental results demonstrate that HMP-ICG&DOX nanoparticles possess excellent biocompatibility, antitumor activity, controlled drug release, and multimodal imaging tracking abilities.
Conclusion: In conclusion, the HMP-ICG&DOX nanoparticles designed in this study offer promising applications in the diagnosis and treatment of pancreatic cancer.
Keywords: pancreatic cancer, magnetic resonance imaging, hollow manganese dioxide, indocyanine green, adriamycin