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已发表论文
多囊卵巢综合征患者阻塞性睡眠呼吸暂停的代谢危险因素评估
Authors Ha LX, Wang JJ, Yuan YY, Liu H, Yang J
Received 27 May 2025
Accepted for publication 31 October 2025
Published 13 November 2025 Volume 2025:17 Pages 4423—4433
DOI https://doi.org/10.2147/IJWH.S543184
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Everett Magann
Ling-Xia Ha,1 Jin-Juan Wang,1 Ying-Ying Yuan,2 Hu Liu,3 Jing Yang3
1Reproductive Center, Peking University First Hospital Ningxia Women and Children’s Hospital, Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan, 750004, People’s Republic of China; 2Reproductive Medicine Center, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 3Ningxia Medical University, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China
Correspondence: Ling-Xia Ha, Reproductive Center, Peking University First Hospital Ningxia Women and Children’s Hospital, Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan, 750004, People’s Republic of China, Tel +86 13629500990, Email halingxia@126.com
Objective: Women diagnosed with PCOS exhibit a high prevalence of obstructive sleep apnea (OSA). This study aims to assess risk factors of OSA among patients with PCOS.
Methods: This retrospective study included 126 patients with PCOS who were categorized into an OSA group (n = 30) and a non-OSA group (n = 96) according to the apnea-hypopnea index (AHI). A control group comprised 72 patients without PCOS who presented during the same period for infertility due to fallopian tube, pelvic, or male factors. Patients with PCOS A multivariate logistic regression model was used to analyze independent risk factors for OSA in the PCOS group.
Results: Patients with PCOS had significantly higher AHI values and elevated values for various physical indicators, including body mass index (BMI) and neck, waist, and hip circumferences; prolactin (PRL); fasting plasma glucose (FPG); insulin (FINS); triglycerides (TG); homeostasis model assessment of insulin resistance (HOMA-IR); 2-hour postprandial glucose (2-hPG) and insulin (2-hINS); AHI; and oxygen desaturation index (ODI). Conversely, levels of high-density lipoprotein cholesterol (HDL-C) and lowest oxygen saturation (LSaO2) were significantly lower (p < 0.05). AHI was positively correlated with BMI, neck circumference, waist circumference, hip circumference, 2-hPG, 2-hINS, and apolipoprotein B/ apolipoprotein A1 (apoB/apoA1) ratio (p < 0.05). BMI and neck circumference as independent risk factors for OSA in patients with PCOS (p < 0.05). The ROC curve analysis of BMI, neck circumference and BMI + neck circumference to predict PCOS patients with OSA showed that AUC=0.838,0.842 and 0.859, respectively, all exhibiting high sensitivity and specificity.
Conclusion: OSA in PCOS patients is linked to metabolic indicators. High neck circumference and BMI levels were independent risk factors, highlighting the need for OSA in routine PCOS screening, particularly in the context of metabolic dysregulation.
Keywords: body mass index, neck circumference, obstructive sleep apnea, polycystic ovary syndrome
1Reproductive Center, Peking University First Hospital Ningxia Women and Children’s Hospital, Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan, 750004, People’s Republic of China; 2Reproductive Medicine Center, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 3Ningxia Medical University, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China
Correspondence: Ling-Xia Ha, Reproductive Center, Peking University First Hospital Ningxia Women and Children’s Hospital, Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan, 750004, People’s Republic of China, Tel +86 13629500990, Email halingxia@126.com
Objective: Women diagnosed with PCOS exhibit a high prevalence of obstructive sleep apnea (OSA). This study aims to assess risk factors of OSA among patients with PCOS.
Methods: This retrospective study included 126 patients with PCOS who were categorized into an OSA group (n = 30) and a non-OSA group (n = 96) according to the apnea-hypopnea index (AHI). A control group comprised 72 patients without PCOS who presented during the same period for infertility due to fallopian tube, pelvic, or male factors. Patients with PCOS A multivariate logistic regression model was used to analyze independent risk factors for OSA in the PCOS group.
Results: Patients with PCOS had significantly higher AHI values and elevated values for various physical indicators, including body mass index (BMI) and neck, waist, and hip circumferences; prolactin (PRL); fasting plasma glucose (FPG); insulin (FINS); triglycerides (TG); homeostasis model assessment of insulin resistance (HOMA-IR); 2-hour postprandial glucose (2-hPG) and insulin (2-hINS); AHI; and oxygen desaturation index (ODI). Conversely, levels of high-density lipoprotein cholesterol (HDL-C) and lowest oxygen saturation (LSaO2) were significantly lower (p < 0.05). AHI was positively correlated with BMI, neck circumference, waist circumference, hip circumference, 2-hPG, 2-hINS, and apolipoprotein B/ apolipoprotein A1 (apoB/apoA1) ratio (p < 0.05). BMI and neck circumference as independent risk factors for OSA in patients with PCOS (p < 0.05). The ROC curve analysis of BMI, neck circumference and BMI + neck circumference to predict PCOS patients with OSA showed that AUC=0.838,0.842 and 0.859, respectively, all exhibiting high sensitivity and specificity.
Conclusion: OSA in PCOS patients is linked to metabolic indicators. High neck circumference and BMI levels were independent risk factors, highlighting the need for OSA in routine PCOS screening, particularly in the context of metabolic dysregulation.
Keywords: body mass index, neck circumference, obstructive sleep apnea, polycystic ovary syndrome