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已发表论文
玻璃体悬韧带在原发性闭角型青光眼术前诊断悬韧带松弛中的作用
Authors Liang Z, Wang Y, Lv K, Ma Y, Lu Y, Wu K, Wu H
Received 28 July 2025
Accepted for publication 5 November 2025
Published 12 November 2025 Volume 2025:19 Pages 4193—4203
DOI https://doi.org/10.2147/OPTH.S556693
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Scott Fraser
Zhiqiao Liang,1,* Yijia Wang,2,* Kun Lv,1 Yao Ma,1 Ye Lu,1 Kuankuan Wu,1 Huijuan Wu1
1Department of Ophthalmology, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Peking University Health Science Center, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huijuan Wu, Department of Ophthalmology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of China, Email dr_wuhuijuan@126.com
Purpose: This study aimed to evaluate the diagnostic value of the number of visible vitreous zonule (VZ) quadrants in predicting zonular laxity in patients with primary angle-closure disease (PACD).
Patients and Methods: This prospective cohort study collected data between the period of November 2021 and February 2024. PACD patients were enrolled, with one eye selected randomly for analysis. The main outcome was the association between the presence/number of quadrants with visible VZ and the presence of zonular laxity. The diagnostic capability of the number of quadrants with VZ in determining zonular laxity was evaluated.
Results: A total of 50 patients were enrolled in the study. Compared with the VZ group, the no VZ group was more likely to manifest zonula laxity (14 of 14 [100%] vs 19 of 36 [53%], P = 0.002). The zonular laxity group had fewer quadrants with visible VZ (1.18 ± 0.22 vs 2.93 ± 0.22, P < 0.001) than the normal group. The number of quadrants for zonular laxity detection achieved an area under the curve of 0.855 (P < 0.001). The highest Youden Index was observed when the number of quadrants was less than 3, indicating superior diagnostic capability for zonular laxity, with a sensitivity of 84.9% and specificity of 70.6%. The highest sensitivity (93.9%) was achieved when the number of quadrants was less than 4.
Conclusion: The study found a link between VZ lack and zonular laxity in PACD, enhancing diagnosis with fewer VZ quadrants, and highlighted VZ’s diagnostic value.
Keywords: vitreous zonule, zonular laxity, primary angle-closure disease, diagnostic capability
1Department of Ophthalmology, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Peking University Health Science Center, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huijuan Wu, Department of Ophthalmology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of China, Email dr_wuhuijuan@126.com
Purpose: This study aimed to evaluate the diagnostic value of the number of visible vitreous zonule (VZ) quadrants in predicting zonular laxity in patients with primary angle-closure disease (PACD).
Patients and Methods: This prospective cohort study collected data between the period of November 2021 and February 2024. PACD patients were enrolled, with one eye selected randomly for analysis. The main outcome was the association between the presence/number of quadrants with visible VZ and the presence of zonular laxity. The diagnostic capability of the number of quadrants with VZ in determining zonular laxity was evaluated.
Results: A total of 50 patients were enrolled in the study. Compared with the VZ group, the no VZ group was more likely to manifest zonula laxity (14 of 14 [100%] vs 19 of 36 [53%], P = 0.002). The zonular laxity group had fewer quadrants with visible VZ (1.18 ± 0.22 vs 2.93 ± 0.22, P < 0.001) than the normal group. The number of quadrants for zonular laxity detection achieved an area under the curve of 0.855 (P < 0.001). The highest Youden Index was observed when the number of quadrants was less than 3, indicating superior diagnostic capability for zonular laxity, with a sensitivity of 84.9% and specificity of 70.6%. The highest sensitivity (93.9%) was achieved when the number of quadrants was less than 4.
Conclusion: The study found a link between VZ lack and zonular laxity in PACD, enhancing diagnosis with fewer VZ quadrants, and highlighted VZ’s diagnostic value.
Keywords: vitreous zonule, zonular laxity, primary angle-closure disease, diagnostic capability