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已发表论文
高尿酸血症性痛风与无症状高尿酸血症患者亚临床心脏功能障碍的比较超声心动图研究
Authors Jiang R, Wen W, Li Q, Dang W, He Y, Wang J, Liu J
Received 29 May 2025
Accepted for publication 23 October 2025
Published 11 November 2025 Volume 2025:18 Pages 6909—6922
DOI https://doi.org/10.2147/IJGM.S531736
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Vinay Kumar
Rufang Jiang,1,* Wen Wen,1,* Qinze Li,1,* Wantai Dang,2,* Yaqun He,1 Jie Wang,1 Jian Liu1
1Department of Ultrasound, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, People’s Republic of China; 2Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jian Liu, Department of Ultrasound, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, People’s Republic of China, 610500, Email liujiansh@126.com
Objective: This study examines subclinical cardiac dysfunction in hyperuricemic populations by comparing echocardiographic parameters—including left ventricular diastolic dysfunction (LVDD), which reflects impaired ventricular relaxation, and left ventricular strain parameters, sensitive markers of early systolic dysfunction—between gout patients and asymptomatic hyperuricemic controls, and identifying echocardiographic and clinical predictors of cardiac impairment.
Methods: A cross-sectional study was conducted involving 202 hyperuricemic patients (100 gout and 102 asymptomatic hyperuricemic patients) from a tertiary rheumatology center (June 2021-May 2023). A comprehensive evaluation included conventional echocardiography and two-dimensional speckle-tracking. Biochemical indexes such as serum uric acid (SUA), lipid profiles, and renal function markers, along with demographic data, were collected. Group comparisons, univariate and multivariate regression analyses, and receiver operating characteristic (ROC) analyses assessed associations between echocardiographic parameters and clinical variables.
Results: Gout patients had a significantly higher prevalence of LVDD (31.00% vs 10.78%, P< 0.001), a lower left ventricular ejection fraction (LVEF) (60.01± 3.92 vs 65.85± 3.78, P< 0.001), and a lower absolute value of global longitudinal strain (GLS) (17.72 vs 19.68, P< 0.001) compared to asymptomatic hyperuricemic patients. SUA positively correlated with GLS (β=0.236, P< 0.05) in gout patients, while body mass index (BMI) and total cholesterol negatively correlated with LVEF (β=− 0.248; − 0.280, respectively, both P< 0.05). In asymptomatic patients, triglycerides positively correlated with GLS and global circumferential strain (β=0.355; 0.310, both P< 0.05). Risk factors for LVDD differed: gout patients showed BMI, creatinine, and course-dependent risks, while asymptomatic patients exhibited BMI and β 2 microglobulin-related risks.
Conclusion: Distinct echocardiographic profiles and risk factor patterns in gout versus asymptomatic hyperuricemia suggest differing mechanisms of cardiac involvement, underscoring the need for tailored cardiovascular monitoring in hyperuricemic populations.
Keywords: gout, hyperuricemia, echocardiography, ventricular function, comparative study
1Department of Ultrasound, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, People’s Republic of China; 2Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jian Liu, Department of Ultrasound, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, People’s Republic of China, 610500, Email liujiansh@126.com
Objective: This study examines subclinical cardiac dysfunction in hyperuricemic populations by comparing echocardiographic parameters—including left ventricular diastolic dysfunction (LVDD), which reflects impaired ventricular relaxation, and left ventricular strain parameters, sensitive markers of early systolic dysfunction—between gout patients and asymptomatic hyperuricemic controls, and identifying echocardiographic and clinical predictors of cardiac impairment.
Methods: A cross-sectional study was conducted involving 202 hyperuricemic patients (100 gout and 102 asymptomatic hyperuricemic patients) from a tertiary rheumatology center (June 2021-May 2023). A comprehensive evaluation included conventional echocardiography and two-dimensional speckle-tracking. Biochemical indexes such as serum uric acid (SUA), lipid profiles, and renal function markers, along with demographic data, were collected. Group comparisons, univariate and multivariate regression analyses, and receiver operating characteristic (ROC) analyses assessed associations between echocardiographic parameters and clinical variables.
Results: Gout patients had a significantly higher prevalence of LVDD (31.00% vs 10.78%, P< 0.001), a lower left ventricular ejection fraction (LVEF) (60.01± 3.92 vs 65.85± 3.78, P< 0.001), and a lower absolute value of global longitudinal strain (GLS) (17.72 vs 19.68, P< 0.001) compared to asymptomatic hyperuricemic patients. SUA positively correlated with GLS (β=0.236, P< 0.05) in gout patients, while body mass index (BMI) and total cholesterol negatively correlated with LVEF (β=− 0.248; − 0.280, respectively, both P< 0.05). In asymptomatic patients, triglycerides positively correlated with GLS and global circumferential strain (β=0.355; 0.310, both P< 0.05). Risk factors for LVDD differed: gout patients showed BMI, creatinine, and course-dependent risks, while asymptomatic patients exhibited BMI and β 2 microglobulin-related risks.
Conclusion: Distinct echocardiographic profiles and risk factor patterns in gout versus asymptomatic hyperuricemia suggest differing mechanisms of cardiac involvement, underscoring the need for tailored cardiovascular monitoring in hyperuricemic populations.
Keywords: gout, hyperuricemia, echocardiography, ventricular function, comparative study