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已发表论文
定量 CT 评估骨骼肌和腹部脂肪分布：对 2 型糖尿病的预测价值
Authors Zhang B , Wu Z , Jiang C, Li N, An X, Tian L, Cai Y, Zou Y, Tang Y
Received 15 July 2025
Accepted for publication 26 October 2025
Published 11 November 2025 Volume 2025:18 Pages 4153—4163
DOI https://doi.org/10.2147/DMSO.S550824
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hillary Keenan
Bo Zhang,1,* Zhe Wu,2,* Chao Jiang,2 Ning Li,2 Xiujing An,1 Lufeng Tian,3 Yang Cai,4 Yanjun Zou,5 Yi Tang6
1College of The Third Clinical Medical College, Jinzhou Medical University, Jinzhou, Liaoning Province, People’s Republic of China; 2Department of Radiology, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China; 3Department of Internal Medicine, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China; 4Department of Medical Record Room, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China; 5Department of Radiology, Ansteel Group General Hospital, Anshan, Liaoning Province, People’s Republic of China; 6Department of Endocrinology, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yanjun Zou, Department of Radiology, Ansteel Group General Hospital, Jianshen Road, Tiedong District, Anshan, Liaoning Province, 114005, People’s Republic of China, Tel +86-139-41225318, Email agzyyxzx@163.com Yi Tang, Department of Endocrinology, Fushun Central Hospital, Xincheng Road, Shuncheng District, Fushun, Liaoning Province, 113006, People’s Republic of China, Tel +86-156-42018668, Email Ty15642018668@163.com
Objective: In this study, we aimed to investigate the association between skeletal muscle area (SMA), subcutaneous fat area (SFA), and visceral fat area (VFA), quantified using computed tomography (CT), and the risk of type 2 diabetes mellitus (T2DM). We also evaluated the predictive performance of these parameters for assessing T2DM risk.
Methods: We used a retrospective case–control design, including 207 hospitalized patients who underwent abdominal quantitative CT (QCT) scans at Fushun Central Hospital from July 2021 to July 2022. Using QCT technology, SMA, SFA, and VFA were measured at the level of the third lumbar vertebra. Additionally, the skeletal muscle index (SMI=SMA/height2) and the visceral-to-subcutaneous fat ratio (VFA/SFA) were calculated. Univariate and multivariate logistic regression analyses were used to examine the association between skeletal muscle and abdominal fat parameters with T2DM, and receiver operating characteristic (ROC) curves evaluated the predictive performance of each indicator.
Results: Body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, VFA, and SFA were significantly higher in the T2DM group compared with the control group, and SMA and SMI were significantly lower (all P< 0.05). Multivariate logistic regression analysis showed that lower SMI (odds ratio [OR]=0.906, 95% confidence interval [CI]: 0.847– 0.970, P=0.004) and greater VFA (OR=1.008, 95% CI: 1.004– 1.012, P< 0.001) were independent risk factors for T2DM. ROC curve analysis showed that SMI (area under the ROC curve [AUC]=0.634) and VFA (AUC=0.697) had moderate predictive performance for T2DM whereas the combined model (SMI+VFA) significantly improved predictive efficacy (AUC=0.816).
Conclusion: Visceral fat accumulation was an independent risk factor for T2DM, and increased skeletal muscle mass showed a protective effect. The combined SMI and VFA model showed significantly enhanced predictive ability for T2DM risk, suggesting its potential as a clinical biomarker.
Keywords: type 2 diabetes mellitus, visceral fat area, subcutaneous fat area, skeletal muscle index, risk prediction
1College of The Third Clinical Medical College, Jinzhou Medical University, Jinzhou, Liaoning Province, People’s Republic of China; 2Department of Radiology, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China; 3Department of Internal Medicine, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China; 4Department of Medical Record Room, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China; 5Department of Radiology, Ansteel Group General Hospital, Anshan, Liaoning Province, People’s Republic of China; 6Department of Endocrinology, Fushun Central Hospital, Fushun, Liaoning Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yanjun Zou, Department of Radiology, Ansteel Group General Hospital, Jianshen Road, Tiedong District, Anshan, Liaoning Province, 114005, People’s Republic of China, Tel +86-139-41225318, Email agzyyxzx@163.com Yi Tang, Department of Endocrinology, Fushun Central Hospital, Xincheng Road, Shuncheng District, Fushun, Liaoning Province, 113006, People’s Republic of China, Tel +86-156-42018668, Email Ty15642018668@163.com
Objective: In this study, we aimed to investigate the association between skeletal muscle area (SMA), subcutaneous fat area (SFA), and visceral fat area (VFA), quantified using computed tomography (CT), and the risk of type 2 diabetes mellitus (T2DM). We also evaluated the predictive performance of these parameters for assessing T2DM risk.
Methods: We used a retrospective case–control design, including 207 hospitalized patients who underwent abdominal quantitative CT (QCT) scans at Fushun Central Hospital from July 2021 to July 2022. Using QCT technology, SMA, SFA, and VFA were measured at the level of the third lumbar vertebra. Additionally, the skeletal muscle index (SMI=SMA/height2) and the visceral-to-subcutaneous fat ratio (VFA/SFA) were calculated. Univariate and multivariate logistic regression analyses were used to examine the association between skeletal muscle and abdominal fat parameters with T2DM, and receiver operating characteristic (ROC) curves evaluated the predictive performance of each indicator.
Results: Body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, VFA, and SFA were significantly higher in the T2DM group compared with the control group, and SMA and SMI were significantly lower (all P< 0.05). Multivariate logistic regression analysis showed that lower SMI (odds ratio [OR]=0.906, 95% confidence interval [CI]: 0.847– 0.970, P=0.004) and greater VFA (OR=1.008, 95% CI: 1.004– 1.012, P< 0.001) were independent risk factors for T2DM. ROC curve analysis showed that SMI (area under the ROC curve [AUC]=0.634) and VFA (AUC=0.697) had moderate predictive performance for T2DM whereas the combined model (SMI+VFA) significantly improved predictive efficacy (AUC=0.816).
Conclusion: Visceral fat accumulation was an independent risk factor for T2DM, and increased skeletal muscle mass showed a protective effect. The combined SMI and VFA model showed significantly enhanced predictive ability for T2DM risk, suggesting its potential as a clinical biomarker.
Keywords: type 2 diabetes mellitus, visceral fat area, subcutaneous fat area, skeletal muscle index, risk prediction