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已发表论文
新兴纳米医学对生殖细胞而言是福是祸？
Authors Yu H, Hu C, Wang X, Zhang Y, Zhang N, Yu P, Lian K, Huang J, Duan P
Received 11 July 2025
Accepted for publication 29 October 2025
Published 11 November 2025 Volume 2025:20 Pages 13621—13639
DOI https://doi.org/10.2147/IJN.S552959
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Farooq A. Shiekh
Hui Yu,1,2,* Chunhui Hu,3,* Xuelin Wang,1 Ying Zhang,1 Nanhui Zhang,1 Pengxia Yu,1,2 Kai Lian,1 Jiaolong Huang,1 Peng Duan1,2
1Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China; 2Hubei Provincial Clinical Research Center for Accurate Fetus Malformation Diagnosis, Department of Obstetrics and Gynecology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China; 3Department of Clinical Laboratory, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peng Duan, Email meduanpeng@163.com Jiaolong Huang, Email huangjiaolong1110@163.com
Abstract: Nanomaterials are increasingly applied in biomedicine and have significant potential in reproductive medicine. However, because they can impact germ cells, use of nanomaterials could represent a “double-edged sword”, whose benefits must be balanced with the possible risks. Because of their excellent physicochemical properties, nanoparticles (NPs) can serve as multi-functional platforms for targeted drug delivery, enhancing outcomes in assisted reproductive technologies, refining in vitro culture systems, and improving the precision of diagnostic imaging. Nevertheless, accumulating evidence indicates that various NPs, including metallic and polymeric forms, can accumulate in reproductive tissues and induce detrimental effects, primarily through increased oxidative stress, DNA damage, and activation of apoptotic pathways. Moreover, NPs can directly compromise gamete quality and function: in oocytes, NP exposure can disrupt key processes, such as meiotic spindle assembly and chromosomal segregation; while in sperm, NPs can impair critical functions, such as histone-to-protamine exchange and mitochondrial integrity. The delicate balance between the benefits and risks of NP use are profoundly influenced by their physicochemical properties. This review critically assesses the “friend or foe” duality of NP use in reproductive medicine, by systematically analyzing their beneficial applications in contrast with their potential for NP-induced toxicity. Mechanistic pathways of NP toxicity are described, and the necessity of a safety-focused approach for the future development of reproductive nanomedicine is emphasised.
Keywords: nanoparticles, reproductive medicine, oxidative stress, gamete quality, nanotoxicology
1Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China; 2Hubei Provincial Clinical Research Center for Accurate Fetus Malformation Diagnosis, Department of Obstetrics and Gynecology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China; 3Department of Clinical Laboratory, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peng Duan, Email meduanpeng@163.com Jiaolong Huang, Email huangjiaolong1110@163.com
Abstract: Nanomaterials are increasingly applied in biomedicine and have significant potential in reproductive medicine. However, because they can impact germ cells, use of nanomaterials could represent a “double-edged sword”, whose benefits must be balanced with the possible risks. Because of their excellent physicochemical properties, nanoparticles (NPs) can serve as multi-functional platforms for targeted drug delivery, enhancing outcomes in assisted reproductive technologies, refining in vitro culture systems, and improving the precision of diagnostic imaging. Nevertheless, accumulating evidence indicates that various NPs, including metallic and polymeric forms, can accumulate in reproductive tissues and induce detrimental effects, primarily through increased oxidative stress, DNA damage, and activation of apoptotic pathways. Moreover, NPs can directly compromise gamete quality and function: in oocytes, NP exposure can disrupt key processes, such as meiotic spindle assembly and chromosomal segregation; while in sperm, NPs can impair critical functions, such as histone-to-protamine exchange and mitochondrial integrity. The delicate balance between the benefits and risks of NP use are profoundly influenced by their physicochemical properties. This review critically assesses the “friend or foe” duality of NP use in reproductive medicine, by systematically analyzing their beneficial applications in contrast with their potential for NP-induced toxicity. Mechanistic pathways of NP toxicity are described, and the necessity of a safety-focused approach for the future development of reproductive nanomedicine is emphasised.
Keywords: nanoparticles, reproductive medicine, oxidative stress, gamete quality, nanotoxicology