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已发表论文
近红外光响应型铜硒化物纳米粒子负载的硅酸钙水泥诱导骨肉瘤细胞发生免疫原性细胞死亡
Authors Liu R , Sun R, Xue Y, Zhou Y, Zhan L, Li Y, Tian Y, Wang C, Feng W, Chang B, Fan B , Gao Q
Received 21 June 2025
Accepted for publication 22 October 2025
Published 11 November 2025 Volume 2025:20 Pages 13587—13607
DOI https://doi.org/10.2147/IJN.S548764
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Dong Wang
Ruitang Liu,1,2,* Ruilong Sun,1,* Yun Xue,1,* Yigui Zhou,1 Longwen Zhan,1 Yunfei Li,1 Yongzheng Tian,1 Chunyang Wang,1 Weike Feng,1 Bin Chang,1 Bo Fan,1 Qiuming Gao1
1Orthopedic Center, The 940th Hospital of the Joint Logistic Support Force of Chinese People’s Liberation Army, Lanzhou, People’s Republic of China; 2Gansu Provincial Key Laboratory of Stem Cells and Gene Drugs, Lanzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Bo Fan, Email fanbo1228@163.com Qiuming Gao, Email gaoqm001@sohu.com
Introduction: Osteosarcoma is a highly malignant tumor posing significant treatment challenges, including limited efficacy of conventional therapies and difficulties in bone defect repair following resection. Although calcium silicate cement (CS) exhibits favorable characteristics as a bone filler, such as moldability and high compressive strength, its inherent lack of antitumor properties restricts its use in oncological contexts.
Methods: A multifunctional composite bone cement was developed by incorporating nano-Cu2-xSe—a photothermal agent synthesized via a one-pot method—into a CS matrix. The material was systematically evaluated in terms of photothermal performance, setting time, compressive strength, and antitumor efficacy through in vitro assays and in vivo experiments using animal models. Mechanistic studies were conducted to assess whether immunogenic cell death (ICD) was induced in tumor cells.
Results: The addition of only 0.2 wt% nano-Cu2-xSe enabled effective photothermal conversion under near-infrared (NIR) irradiation, reaching temperatures necessary for photothermal therapy (PTT). The composite cement also exhibited a shorter setting time and higher compressive strength compared to pure CS. Both in vitro and in vivo tests confirmed its potent antitumor efficacy, with mechanistic analysis revealing the induction of ICD in tumor cells.
Discussion: This composite cement constitutes a dual-functional system capable of supporting bone defect repair while providing a photothermal antitumor effect, with potential immunogenic properties. The combination of improved material properties and efficient PTT performance highlights its promise as a strategy for treating bone tumors in a preclinical setting. These results support further development of this material for future translational studies in bone tissue engineering and oncology.
Keywords: nano particle, photothermal therapy, calcium silicate, osteosarcoma, immunogenic cell death
1Orthopedic Center, The 940th Hospital of the Joint Logistic Support Force of Chinese People’s Liberation Army, Lanzhou, People’s Republic of China; 2Gansu Provincial Key Laboratory of Stem Cells and Gene Drugs, Lanzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Bo Fan, Email fanbo1228@163.com Qiuming Gao, Email gaoqm001@sohu.com
Introduction: Osteosarcoma is a highly malignant tumor posing significant treatment challenges, including limited efficacy of conventional therapies and difficulties in bone defect repair following resection. Although calcium silicate cement (CS) exhibits favorable characteristics as a bone filler, such as moldability and high compressive strength, its inherent lack of antitumor properties restricts its use in oncological contexts.
Methods: A multifunctional composite bone cement was developed by incorporating nano-Cu2-xSe—a photothermal agent synthesized via a one-pot method—into a CS matrix. The material was systematically evaluated in terms of photothermal performance, setting time, compressive strength, and antitumor efficacy through in vitro assays and in vivo experiments using animal models. Mechanistic studies were conducted to assess whether immunogenic cell death (ICD) was induced in tumor cells.
Results: The addition of only 0.2 wt% nano-Cu2-xSe enabled effective photothermal conversion under near-infrared (NIR) irradiation, reaching temperatures necessary for photothermal therapy (PTT). The composite cement also exhibited a shorter setting time and higher compressive strength compared to pure CS. Both in vitro and in vivo tests confirmed its potent antitumor efficacy, with mechanistic analysis revealing the induction of ICD in tumor cells.
Discussion: This composite cement constitutes a dual-functional system capable of supporting bone defect repair while providing a photothermal antitumor effect, with potential immunogenic properties. The combination of improved material properties and efficient PTT performance highlights its promise as a strategy for treating bone tumors in a preclinical setting. These results support further development of this material for future translational studies in bone tissue engineering and oncology.
Keywords: nano particle, photothermal therapy, calcium silicate, osteosarcoma, immunogenic cell death