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已发表论文
慢性阻塞性肺疾病（2005 - 2024 年）研究趋势：从药物治疗到综合康复策略
Authors Zhan M, Chen J, Zhang H
Received 18 June 2025
Accepted for publication 29 October 2025
Published 11 November 2025 Volume 2025:20 Pages 3659—3671
DOI https://doi.org/10.2147/COPD.S548108
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Jill Ohar
Miao Zhan,1,2 Jing Chen,2,3 Hongying Zhang1,2
1Department of Science and Education, The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing city, 400084, People’s Republic of China; 2School of Nursing, Chongqing Medical University, Chongqing city, 400016, People’s Republic of China; 3Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing city, 400010, People’s Republic of China
Correspondence: Hongying Zhang, Department of Science and Education, The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing city, 400084, People’s Republic of China, Email 900009@hospital.cqmu.edu.cn
Objective: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, which has driven efficient and economical management strategies to become a research focus. This study conducted a bibliometric analysis of drug treatment and comprehensive rehabilitation strategies for COPD, providing a scientific basis for future COPD management and offering valuable information and guidance to clinicians, researchers, and policymakers to optimize clinical treatment plans for COPD.
Materials and Methods: Using the statistical analysis software CiteSpace6.4. R1, 11,417 articles exported from the Web of Science Core Collection and Scopus from January 1, 2005, to December 31, 2024, were quantitatively analyzed in terms of annual publication volume, countries, institutions, and keywords, and presented in the form of graphs.
Results: After systematic screening, 3668 articles were included. The annual number of published papers in this field is increasing, but little cooperation has been observed between countries and institutions. In terms of contribution, the United States and the United Kingdom are in leading positions. At the institutional level, Sapienza University of Rome in Italy published the largest number of papers. The high-frequency keywords were pulmonary rehabilitation, quality of life, and bronchodilating agents. Keyword emergent analysis results showed that targeted drugs and intelligent healthcare are new research hotspots.
Conclusion: The management of COPD has achieved a fundamental transformation from being “drug-centered” to “patient-centered”. Research hotspots are mainly focused on bronchodilators and pulmonary rehabilitation, whereas targeted drugs and intelligent healthcare represent future directions of individualization and precision. In future, drugs, rehabilitation, and intelligent technologies should be integrated to build a full-process management model, and key empirical support should be provided through strengthened international collaboration.
Keywords: COPD, combination therapy, pulmonary rehabilitation, intelligent healthcare, bibliometrics
1Department of Science and Education, The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing city, 400084, People’s Republic of China; 2School of Nursing, Chongqing Medical University, Chongqing city, 400016, People’s Republic of China; 3Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing city, 400010, People’s Republic of China
Correspondence: Hongying Zhang, Department of Science and Education, The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing city, 400084, People’s Republic of China, Email 900009@hospital.cqmu.edu.cn
Objective: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, which has driven efficient and economical management strategies to become a research focus. This study conducted a bibliometric analysis of drug treatment and comprehensive rehabilitation strategies for COPD, providing a scientific basis for future COPD management and offering valuable information and guidance to clinicians, researchers, and policymakers to optimize clinical treatment plans for COPD.
Materials and Methods: Using the statistical analysis software CiteSpace6.4. R1, 11,417 articles exported from the Web of Science Core Collection and Scopus from January 1, 2005, to December 31, 2024, were quantitatively analyzed in terms of annual publication volume, countries, institutions, and keywords, and presented in the form of graphs.
Results: After systematic screening, 3668 articles were included. The annual number of published papers in this field is increasing, but little cooperation has been observed between countries and institutions. In terms of contribution, the United States and the United Kingdom are in leading positions. At the institutional level, Sapienza University of Rome in Italy published the largest number of papers. The high-frequency keywords were pulmonary rehabilitation, quality of life, and bronchodilating agents. Keyword emergent analysis results showed that targeted drugs and intelligent healthcare are new research hotspots.
Conclusion: The management of COPD has achieved a fundamental transformation from being “drug-centered” to “patient-centered”. Research hotspots are mainly focused on bronchodilators and pulmonary rehabilitation, whereas targeted drugs and intelligent healthcare represent future directions of individualization and precision. In future, drugs, rehabilitation, and intelligent technologies should be integrated to build a full-process management model, and key empirical support should be provided through strengthened international collaboration.
Keywords: COPD, combination therapy, pulmonary rehabilitation, intelligent healthcare, bibliometrics