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已发表论文
慢性阻塞性肺疾病患者体重调整腰围指数与全因及心血管疾病死亡率的关联：一项回顾性队列研究
Authors Zhang X , Zhang W, Hu Y , Yang G, Liu S, Hao W, Qu Y
Received 6 June 2025
Accepted for publication 29 October 2025
Published 11 November 2025 Volume 2025:20 Pages 3647—3658
DOI https://doi.org/10.2147/COPD.S545141
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Jill Ohar
Xiaoning Zhang,* Wenqing Zhang,* Yajie Hu, Guang Yang, Shuangteng Liu, Wenqiang Hao, Yiqing Qu
Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yiqing Qu, Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, No. 107 Wenhuaxi Road, Jinan, 250012, People’s Republic of China, Email quyiqing@sdu.edu.cn
Purpose: This study aims to evaluate potential associations between the weight-adjusted waist index (WWI) and all-cause and cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD).
Methods: Our investigation analyzed data from the National Health and Nutrition Examination Survey (NHANES, 1999– 2018). From an initial cohort of 101,316 participants, we incorporated 1,396 qualified individuals with COPD. To investigate the relationship between WWI and mortality, we employed multiple analytical methods, including multivariate Cox proportional hazards regression, Kaplan-Meier survival analysis, subgroup stratification and restricted cubic spline (RCS) modeling. Additionally, the prognostic utility of WWI in predicting mortality risk was further assessed through time-dependent receiver operating characteristic (ROC) curve analysis.
Results: In fully adjusted models, the highest WWI tertile (T3) revealed higher risks for both all-cause mortality (HR: 1.82, 95% CI: 1.19– 2.77, p=0.006) and CVD mortality (HR: 2.79, 95% CI: 1.48– 5.26, p=0.002) compared to the lowest tertile (T1). RCS analyses revealed a strong and statistically significant linear association between WWI and mortality risk. These findings suggest that WWI may be a meaningful predictor of adverse outcomes in COPD.
Conclusion: Our study demonstrates that higher WWI significantly predicts increased mortality risk in COPD patients, highlighting its prognostic value and suggesting potential utility for risk stratification in clinical practice.
Keywords: chronic obstructive pulmonary disease, weight-adjusted waist index, mortality, NHANES
Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yiqing Qu, Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, No. 107 Wenhuaxi Road, Jinan, 250012, People’s Republic of China, Email quyiqing@sdu.edu.cn
Purpose: This study aims to evaluate potential associations between the weight-adjusted waist index (WWI) and all-cause and cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD).
Methods: Our investigation analyzed data from the National Health and Nutrition Examination Survey (NHANES, 1999– 2018). From an initial cohort of 101,316 participants, we incorporated 1,396 qualified individuals with COPD. To investigate the relationship between WWI and mortality, we employed multiple analytical methods, including multivariate Cox proportional hazards regression, Kaplan-Meier survival analysis, subgroup stratification and restricted cubic spline (RCS) modeling. Additionally, the prognostic utility of WWI in predicting mortality risk was further assessed through time-dependent receiver operating characteristic (ROC) curve analysis.
Results: In fully adjusted models, the highest WWI tertile (T3) revealed higher risks for both all-cause mortality (HR: 1.82, 95% CI: 1.19– 2.77, p=0.006) and CVD mortality (HR: 2.79, 95% CI: 1.48– 5.26, p=0.002) compared to the lowest tertile (T1). RCS analyses revealed a strong and statistically significant linear association between WWI and mortality risk. These findings suggest that WWI may be a meaningful predictor of adverse outcomes in COPD.
Conclusion: Our study demonstrates that higher WWI significantly predicts increased mortality risk in COPD patients, highlighting its prognostic value and suggesting potential utility for risk stratification in clinical practice.
Keywords: chronic obstructive pulmonary disease, weight-adjusted waist index, mortality, NHANES