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已发表论文
单胺氧化酶 B 在癌症中的作用：对治疗和预后的启示
Authors Liu Y, Li D, Xie C, Pan Y , Shi Q
Received 17 May 2025
Accepted for publication 4 September 2025
Published 8 November 2025 Volume 2025:18 Pages 15555—15586
DOI https://doi.org/10.2147/JIR.S541110
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Ning Quan
Yu Liu,1,* Daosheng Li,2,* Changpeng Xie,3,* Yuanming Pan,4 Qing Shi1
1Department of Hepatology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, Jiangxi, 332001, People’s Republic of China; 2Department of Oncology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, Jiangxi, 332001, People’s Republic of China; 3Department of Basic Medical Sciences, Qinghai University, Xi’ning, Qinghai, 810008, People’s Republic of China; 4Cancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qing Shi, Department of Hepatology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, No. 48 Taling South Road, Xunyang District, Jiujiang, Jiangxi, 332001, People’s Republic of China, Tel/Fax +86-792-8171670, Email 13767200204@163.com Yuanming Pan, Cancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, No. 9 Beiguan Street, Tongzhou District, Beijing, 101149, People’s Republic of China, Tel/Fax +86-10-89509372, Email peterfpan2020@mail.ccmu.edu.cn
Abstract: Monoamine oxidase B (MAOB) is an enzyme implicated in various physiological and pathological processes, particularly in the context of cancer. This review comprehensively examines the metabolic functions of MAOB within its dual implications in tumorigenesis. MAOB is significantly involved in regulating the levels of monoamines, including dopamine, and its dysregulation is associated with neurodegenerative diseases and cancer progression. Elevated MAOB activity has been linked to increased oxidative stress, contributing to tumor growth and metastasis through enhanced glycolysis and mitochondrial dysfunction. Furthermore, MAOB’s influence on the tumor microenvironment is evidenced by its modulation of key signaling pathways such as NF-κB and PI3K/AKT, impacting immune response and tumor behaviors. This review discusses the distinct expression patterns of MAOB across various cancer types and its potential as a prognostic marker and therapeutic target. We outline ongoing efforts in the development of small molecule inhibitors of MAOB, investigating their mechanisms of action, efficacy, and potential combination therapies with traditional chemotherapeutics and immunotherapies. The integration of multi-omics approaches is emphasized as a future direction to further elucidate MAOB’s role in cancer biology and refine personalized therapeutic strategies.
Keywords: MAOB, cancer metabolism, oxidative stress, prognostic marker, therapeutic target
1Department of Hepatology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, Jiangxi, 332001, People’s Republic of China; 2Department of Oncology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, Jiangxi, 332001, People’s Republic of China; 3Department of Basic Medical Sciences, Qinghai University, Xi’ning, Qinghai, 810008, People’s Republic of China; 4Cancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qing Shi, Department of Hepatology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, No. 48 Taling South Road, Xunyang District, Jiujiang, Jiangxi, 332001, People’s Republic of China, Tel/Fax +86-792-8171670, Email 13767200204@163.com Yuanming Pan, Cancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, No. 9 Beiguan Street, Tongzhou District, Beijing, 101149, People’s Republic of China, Tel/Fax +86-10-89509372, Email peterfpan2020@mail.ccmu.edu.cn
Abstract: Monoamine oxidase B (MAOB) is an enzyme implicated in various physiological and pathological processes, particularly in the context of cancer. This review comprehensively examines the metabolic functions of MAOB within its dual implications in tumorigenesis. MAOB is significantly involved in regulating the levels of monoamines, including dopamine, and its dysregulation is associated with neurodegenerative diseases and cancer progression. Elevated MAOB activity has been linked to increased oxidative stress, contributing to tumor growth and metastasis through enhanced glycolysis and mitochondrial dysfunction. Furthermore, MAOB’s influence on the tumor microenvironment is evidenced by its modulation of key signaling pathways such as NF-κB and PI3K/AKT, impacting immune response and tumor behaviors. This review discusses the distinct expression patterns of MAOB across various cancer types and its potential as a prognostic marker and therapeutic target. We outline ongoing efforts in the development of small molecule inhibitors of MAOB, investigating their mechanisms of action, efficacy, and potential combination therapies with traditional chemotherapeutics and immunotherapies. The integration of multi-omics approaches is emphasized as a future direction to further elucidate MAOB’s role in cancer biology and refine personalized therapeutic strategies.
Keywords: MAOB, cancer metabolism, oxidative stress, prognostic marker, therapeutic target