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已发表论文
多模态纳米抗菌策略在人工关节感染中的应用进展：系统综述
Authors Zhang Z, Sun J , Luo Y, Huang C, Xiao W, Wang W
Received 27 June 2025
Accepted for publication 8 November 2025
Published 20 November 2025 Volume 2025:20 Pages 13989—14013
DOI https://doi.org/10.2147/IJN.S550011
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Eng San Thian
Ziming Zhang,1,* Jianfeng Sun,2,3,* Yan Luo,2,3 Cheng Huang,4 Wenfeng Xiao,2,3 Weiguo Wang4
1Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 4Department of Orthopaedic, China-Japan Friendship Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenfeng Xiao, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China, Email xiaowenfeng@csu.edu.cn Weiguo Wang, Department of Orthopedics, China-Japan Friendship Hospital, Beijing, People’s Republic of China, Email jointwwg@163.com
Background: Prosthetic joint infection (PJI), a severe complication following total joint arthroplasty, is characterized by prolonged treatment duration, high costs, and poor outcomes. Current clinical treatment which typically relies on the use of antibiotic-loaded bone cement (ALBC) is limited by the generalization of bacterial resistance and the inherent defects of bone cement. Advancements in nanotechnology have led to nanomaterials and nanocoatings that offer promising alternative strategies, showing great potential for the prevention and management of PJI. This review aims to summarize the applications of nanotechnology in preventing and treating PJI following total joint arthroplasty and further discuss current advances and future perspectives in this field.
Methods: PubMed, Web of Science, Scopus and Embase were searched for relevant studies covering the period from their inception to June 12, 2025. After removal of duplicate records, studies were excluded based on their abstract and title. The remaining studies were assessed for eligibility based on their full-text content.
Conclusion: Nanotechnology has emerged as a highly promising alternative strategy against PJI. The current research frontiers encompass not only the development of stimulus-responsive nanomaterials for precise antibacterial control but also exploring their integration with targeted therapies, immunotherapy, and piezoelectric-based therapy.
Keywords: prosthetic joint infection, nanotechnology, nanomaterials, antibacterial
1Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 4Department of Orthopaedic, China-Japan Friendship Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenfeng Xiao, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China, Email xiaowenfeng@csu.edu.cn Weiguo Wang, Department of Orthopedics, China-Japan Friendship Hospital, Beijing, People’s Republic of China, Email jointwwg@163.com
Background: Prosthetic joint infection (PJI), a severe complication following total joint arthroplasty, is characterized by prolonged treatment duration, high costs, and poor outcomes. Current clinical treatment which typically relies on the use of antibiotic-loaded bone cement (ALBC) is limited by the generalization of bacterial resistance and the inherent defects of bone cement. Advancements in nanotechnology have led to nanomaterials and nanocoatings that offer promising alternative strategies, showing great potential for the prevention and management of PJI. This review aims to summarize the applications of nanotechnology in preventing and treating PJI following total joint arthroplasty and further discuss current advances and future perspectives in this field.
Methods: PubMed, Web of Science, Scopus and Embase were searched for relevant studies covering the period from their inception to June 12, 2025. After removal of duplicate records, studies were excluded based on their abstract and title. The remaining studies were assessed for eligibility based on their full-text content.
Conclusion: Nanotechnology has emerged as a highly promising alternative strategy against PJI. The current research frontiers encompass not only the development of stimulus-responsive nanomaterials for precise antibacterial control but also exploring their integration with targeted therapies, immunotherapy, and piezoelectric-based therapy.
Keywords: prosthetic joint infection, nanotechnology, nanomaterials, antibacterial