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已发表论文
近期关于多模式非药物干预治疗老年抑郁症的研究进展
Authors Xu T, Mao Y, Wang Y, Gong Y, Yu E
Received 22 August 2025
Accepted for publication 11 November 2025
Published 20 November 2025 Volume 2025:21 Pages 2525—2544
DOI https://doi.org/10.2147/NDT.S558969
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Taro Kishi
Tianmei Xu,1,2 Yanping Mao,2 Ye Wang,3 Yi Gong,1 Enyan Yu2
1The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Psychiatry, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People’s Republic of China; 3Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Enyan Yu, Department of Psychiatry, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), 1 Banshandong Road, Hangzhou, Zhejiang, 310022, People’s Republic of China, Tel +86 0571-88122222, Email yuenyan@aliyun.com
Abstract: Late-life depression (LLD) is a common mental disorder that significantly accelerates cognitive decline, increases the risk of somatic comorbidities, and increases all-cause mortality. Traditional pharmacotherapy for this population faces significant limitations, including increased pharmacokinetic sensitivity, anticholinergic burden, and adverse events associated with multiple medications. These factors collectively lead to poor adherence and limited long-term efficacy. This narrative literature review was conducted using studies retrieved from PubMed, ScienceDirect, and Google Scholar, with general search phrases on LLD and non-pharmacological interventions. The inclusion criteria were clinical trials, meta-analyses, and systematic reviews published between 2020 and 2025. Studies that were finally selected were comprehensively evaluated, with non-English literature and case reports excluded. Non-pharmacological interventions have become a core strategy for the management of LLD due to the advantages of high safety, fewer side effects, and a multi-target nature. Psychotherapy, physical intervention, digital technology, and lifestyle modification can effectively improve patients’ depressive symptoms, improve quality of life, reduce the risk of relapse, and serve as possible alternatives and supplementary treatment options for older patients. There is a need for more in-depth research on non-pharmacological interventions for LLD. Future studies should explore the combined application of different non-pharmacological treatments to optimize treatment plans. Developing individualized non-pharmacological treatment plans to improve the accuracy of treatment and reduce the burden of disease should be considered.
Keywords: older adults, psychiatric disorder, therapy
1The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Psychiatry, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People’s Republic of China; 3Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Enyan Yu, Department of Psychiatry, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), 1 Banshandong Road, Hangzhou, Zhejiang, 310022, People’s Republic of China, Tel +86 0571-88122222, Email yuenyan@aliyun.com
Abstract: Late-life depression (LLD) is a common mental disorder that significantly accelerates cognitive decline, increases the risk of somatic comorbidities, and increases all-cause mortality. Traditional pharmacotherapy for this population faces significant limitations, including increased pharmacokinetic sensitivity, anticholinergic burden, and adverse events associated with multiple medications. These factors collectively lead to poor adherence and limited long-term efficacy. This narrative literature review was conducted using studies retrieved from PubMed, ScienceDirect, and Google Scholar, with general search phrases on LLD and non-pharmacological interventions. The inclusion criteria were clinical trials, meta-analyses, and systematic reviews published between 2020 and 2025. Studies that were finally selected were comprehensively evaluated, with non-English literature and case reports excluded. Non-pharmacological interventions have become a core strategy for the management of LLD due to the advantages of high safety, fewer side effects, and a multi-target nature. Psychotherapy, physical intervention, digital technology, and lifestyle modification can effectively improve patients’ depressive symptoms, improve quality of life, reduce the risk of relapse, and serve as possible alternatives and supplementary treatment options for older patients. There is a need for more in-depth research on non-pharmacological interventions for LLD. Future studies should explore the combined application of different non-pharmacological treatments to optimize treatment plans. Developing individualized non-pharmacological treatment plans to improve the accuracy of treatment and reduce the burden of disease should be considered.
Keywords: older adults, psychiatric disorder, therapy