已发表论文

2021 年全球疾病负担研究视角下中国女性与美国及全球女性无牙症趋势展望

 

Authors Chen H, Jing Y, Song Y, Jia Z, He X, Zhang S , Wu M 

Received 5 August 2025

Accepted for publication 13 November 2025

Published 20 November 2025 Volume 2025:17 Pages 4661—4670

DOI https://doi.org/10.2147/IJWH.S558621

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Vinay Kumar

Hao Chen,* Yujie Jing,* Yanbin Song, Zhi Jia, Xin He, Shuangyue Zhang, Meng Wu

Department of Stomatology, Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, Huaian, Jiangsu Province, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Meng Wu, Department of Stomatology, Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, Huaian, Jiangsu Province, 223300, People’s Republic of China, Email hayywm@njmu.edu.cn Shuangyue Zhang, Department of Stomatology, Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, Huaian, Jiangsu Province, 223300, People’s Republic of China, Email hayyzhshy@njmu.edu.cn

Background: Edentulism, the complete loss of natural teeth, remains a major public health issue worldwide, particularly affecting women and older adults. This study aims to evaluate the disease burden of edentulism among women in China, the United States, and globally, addressing the gap that few prior studies have conducted sex-specific comparative analyses of edentulism to inform policy-making and resource allocation for women’s oral health.
Methods: This retrospective, population-based study used data from the Global Burden of Disease (GBD) 2021, a worldwide program that evaluates and compares health outcomes—including mortality and disability—across diseases and populations. We analyzed the incidence and Years Lived with Disability (YLD) of edentulism among women in China, the United States, and globally from 2002 to 2021. Age-standardized rates (ASR), Estimated Annual Percentage Change (EAPC), and Bayesian Age–Period–Cohort (APC) models were applied to assess temporal effects and predict trends to 2046.
Results: China’s age-standardized incidence rate (ASIR) remained consistently below the global average ASIR derived from the GBD 2021 dataset, with a brief period (2006– 2012) where it exceeded that of the United States. Age-specific analysis revealed that edentulism incidence increased most prominently among younger women in China (20– 29 years) and older women in the United States (65– 84 years). The APC analysis revealed that edentulism in China peaked around age 75, while in the United States, it peaked at age 65. Predictions indicate that ASIR in both countries will continue to rise from 2022 to 2046.
Conclusion: The study highlights a concerning upward trend in the burden of edentulism, particularly among young women in China and elderly women in United States. Predictions suggest a sustained increase in incidence rates in these regions, underscoring the need for stronger healthcare policies and resource allocation toward preventive and rehabilitative dental care for women.

Keywords: edentulism, women’s oral health, China, United States, Global Burden of Disease, age-period-cohort analysis, Bayesian prediction