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已发表论文
基于近红外花菁染料的荧光纳米探针在肿瘤成像与治疗中的最新进展
Authors Gao Y, Zhu L, Du Z, Xiong J, Ma R, Aili M, Alifu N , Dong B
Received 26 May 2025
Accepted for publication 15 October 2025
Published 19 November 2025 Volume 2025:20 Pages 13911—13937
DOI https://doi.org/10.2147/IJN.S542880
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Jie Huang
Yuxiang Gao,1 Lijun Zhu,1 Zhong Du,1 Jiabao Xiong,1 Rong Ma,2 Maierhaba Aili,2 Nuernisha Alifu,1,3 Biao Dong3,4
1The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi, People’s Republic of China; 2The First Affiliated Hospital of Xinjiang Medical University, The First Clinical College of Xinjiang Medical University, Urumqi, People’s Republic of China; 3State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, People’s Republic of China; 4State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, People’s Republic of China
Correspondence: Nuernisha Alifu, Email nens_xjmu@126.com Biao Dong, Email dongb@jlu.edu.cn
Abstract: The early detection and high mortality rate of tumors have become great challenges in modern medicine. Recently, innovations in nanotechnology have provided a new paradigm in tumor accurate diagnosis and treatment. As the typical type of organic nanoprobes, near-infrared (NIR) cyanine dye-based fluorescent nanoprobes retain the inherent high luminescence efficiency and good biocompatibility of cyanine dyes. Due to their unique structure and excellent optical properties, some of them have been approved by the US Food and Drug Administration (FDA). Furthermore, cyanine dyes have exhibited dual photo-induced therapeutic functions of photothermal therapy (PTT) and photodynamic therapy (PDT). Notably, the high stability and tunable molecular structure of cyanine dyes allow for more stable binding to other contrast and therapeutic agents, expanding their use in biomedical diagnostics and therapeutics. To date, numerous studies have demonstrated the significant application potential of cyanine nanoprobes, garnering widespread attention from researchers. In this work, we provided a comprehensive overview of the novel applications of cyanine dye-based nanoprobes. Specifically, we discussed their unique properties and applications in fluorescence imaging, photoacoustic imaging, and multimodal tumor imaging. Additionally, we elucidate molecular design strategies, underlying mechanisms, and therapeutic applications of cyanine nanoprobes.
Keywords: cyanine dyes, near-infrared fluorescence, multimodal imaging, photothermal therapy, photodynamic therapy, combination therapy
1The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi, People’s Republic of China; 2The First Affiliated Hospital of Xinjiang Medical University, The First Clinical College of Xinjiang Medical University, Urumqi, People’s Republic of China; 3State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, People’s Republic of China; 4State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, People’s Republic of China
Correspondence: Nuernisha Alifu, Email nens_xjmu@126.com Biao Dong, Email dongb@jlu.edu.cn
Abstract: The early detection and high mortality rate of tumors have become great challenges in modern medicine. Recently, innovations in nanotechnology have provided a new paradigm in tumor accurate diagnosis and treatment. As the typical type of organic nanoprobes, near-infrared (NIR) cyanine dye-based fluorescent nanoprobes retain the inherent high luminescence efficiency and good biocompatibility of cyanine dyes. Due to their unique structure and excellent optical properties, some of them have been approved by the US Food and Drug Administration (FDA). Furthermore, cyanine dyes have exhibited dual photo-induced therapeutic functions of photothermal therapy (PTT) and photodynamic therapy (PDT). Notably, the high stability and tunable molecular structure of cyanine dyes allow for more stable binding to other contrast and therapeutic agents, expanding their use in biomedical diagnostics and therapeutics. To date, numerous studies have demonstrated the significant application potential of cyanine nanoprobes, garnering widespread attention from researchers. In this work, we provided a comprehensive overview of the novel applications of cyanine dye-based nanoprobes. Specifically, we discussed their unique properties and applications in fluorescence imaging, photoacoustic imaging, and multimodal tumor imaging. Additionally, we elucidate molecular design strategies, underlying mechanisms, and therapeutic applications of cyanine nanoprobes.
Keywords: cyanine dyes, near-infrared fluorescence, multimodal imaging, photothermal therapy, photodynamic therapy, combination therapy